Formulation and Evaluation of Mouth Dissolving Tablet: Review Article (original) (raw)

New Approach on Rapid Mouth Dissolving Tablets: A Review

2013

Mouth Dissolving Tablet (MDT) technology has been gaining significance now-a-days with wide variety of drugs serving many purposes. Mouth Dissolving Tablets (MDT) has ever increased their demand in the last decade since they disintegrate in saliva in less than 60 seconds. Mouth Dissolving Drug Delivery Systems serves as a major benefit over the conventional dosage forms since the drug gets rapidly disintegrated & dissolves in the saliva without the use of water. In spite of the downside i.e., lack of immediate onset of action; these oral dosage forms have beneficial such as self-medication, increased the patient compliance, ease of manufacturing and lack of pain as comparison to conventional technologies. The objective of this article is to review the development of MDTs, challenges in formulation, he objective of this article is to review the development of MDTs, challenges in formulation, benefit, limitation ,new MDT technologies and evaluation methodologies.benefit, limitation ...

A REVIEW ON TECHNOLOGIES EMPLOYED IN FORMULATION OF MOUTH DISSOLVING TABLETS

Oral route is the most preferred route for administration of various drugs because it is regarded as safest, most convenient and economical route. Recently researcher developed the mouth dissolving tablets with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. Mouth dissolving tablets overcome the disadvantages of conventional dosage form especially dysphagia (difficulty in swallowing) in paediatric and geriatric patients. Mouth dissolving tablets can be formulated by using various technologies like lyophilization, direct compression, spray drying, molding, nanotization, mass extrusion, sublimation, cotton candy and phase transition technology along with various patented technologies like zydis,lyoc, flashtab, frosta, nanocrystal technology, wowtab, durasolv, orasolv advatab and flashdose technology. This review briefly describes about the various technologies which are used for the formulation of mouth dissolving tablets along with advantages and limitations of the technology.

A Review on Mouth Dissolving Tablets

INDIAN DRUGS, 2013

Mouth Dissolving Tablets (MDTs) have received ever-increasing demand during the last decade and the field has become a rapidly growing area of research in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several MDT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail MDT technologies based on lyophilization, moulding, sublimation and compaction, as well as approaches to enhance the MDT properties, such as spray drying, moisture treatment, sintering, and use of sugar-based disintegrants.

MOUTH DISSOLVING TABLETS: AS A POTENTIAL DRUG DELIVERY SYSTEM - A REVIEW

2011

In the present scenario, there is an ever increasing demand for more patient compliant dosage forms. One of an important innovation in this direction is the development of mouth dissolving tablets that dissolve or disintegrate instantly upon contact with recipient's tongue or buccal mucosa. They have proved to be ideal for geriatric and pediatric population, people suffering from dysphagia, clinical conditions where water intake is not available and for drugs undergoing high first pass metabolism. Mouth dissolving tablets (MDT) are the one which suit the concept of better patient compliance, rapid absorption, rapid onset of action, more efficacy, enough bioavailability to show required pharmacological action and less toxicity. It is found that about 26% of patients experience difficulty to swallow the solid dosage forms like tablets and capsules etc. MDTs show rapid disintegration or dissolution in no time through various mechanisms when placed over the tongue without the need of water and overcome the disadvantages of conventional solid dosage forms. Mouth dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems which aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. The aim of this review is to describe the past and the present of mouth dissolving tablet dosage form.

Mouth Dissolving Tablets-A Review

Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded to be safe, economical, easy to form and the most important is the patient compliance. Other various dosage forms are also available in the market which are used to prevent, care and treat the diseases. But the tablets are most popular among all the dosage forms existing because of its ease of administration, rigidness and patient compliance. But many patients express difficulty in swallowing tablets so to overcome this problem recent advances in drug delivery has expressed dosage forms which disintegrates rapidly when placed upon tongue usually within a matter of second's i.e in 60 secs. These are novel dosage forms which dissolve in saliva within a few seconds, when put on tongue. MDTs can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients.

MOUTH DISSOLVING TABLETS: AS A POTENTIAL DRUG DELIVERY SYSTEM - A REVIEW Review Article

2011

In the present scenario, there is an ever increasing demand for more patient compliant dosage forms. One of an important innovation in this direction is the development of mouth dissolving tablets that dissolve or disintegrate instantly upon contact with recipient’s tongue or buccal mucosa. They have proved to be ideal for geriatric and pediatric population, people suffering from dysphagia, clinical conditions where water intake is not available and for drugs undergoing high first pass metabolism. Mouth dissolving tablets (MDT) are the one which suit the concept of better patient compliance, rapid absorption, rapid onset of action, more efficacy, enough bioavailability to show required pharmacological action and less toxicity. It is found that about 26% of patients experience difficulty to swallow the solid dosage forms like tablets and capsules etc. MDTs show rapid disintegration or dissolution in no time through various mechanisms when placed over the tongue without the need of wa...

Mouth Dissolving Tablets -An Overview

Mouth dissolving tablets (MDT) have received ever increasing demand during last decade and It is a rapidly a growing area in the pharmaceutical industry. After introduction into the mouth these tablets dissolve or disintegrate in the mouth and leaving an easy to swallow residue. Novel MDTs address the patient and pharmaceutical needs of convenient dosing particularly for busy or traveling patient, pediatric, geriatric and psychiatric patients who have difficulty in swallowing (dysphagia) conventional tablets and capsules. These tablets also have faster onset of action due to buccal absorption of the drug. The popularity and usefulness of the formulation resulted in development of several MDT Technologies. It is expected that this delivery system will get more importance in future as that of conventional delivery systems.

Formulation of Mouth Dissolving Tablets Using Solid Dispersion Technique: A Review

Indian Journal of Pharmaceutical and Biological Research, 2018

Mouth-dissolving tablets are also called as fast disintegrating tablets, melt-in mouth tablets, orodispersible tablets, quick dissolving etc. Mouth dissolving tablets are those when put on tongue disintegrate rapidly thereby releasing the drug, which dissolve or disperses in the saliva. The faster the drug dissolved into solution, quick will be the absorption and onset of clinical effect. Mouth dissolving tablet containing solid dispersion was developed to improve the solubility of drug and stability of solid dispersion. Such tablets are disintegrate and/or dissolve rapidly in the saliva without the need for water. Hence it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. The later portion of the article focus on the progress in methods of manufacturing, evaluation and various latest technologies involved in the development of Mouth dissolving tablets. Solid dispersion is basically a drug with polymer two-c...

An Overview on Mouth Dissolving Tablets

Oral route having the high patient compliance in regarded as the most convenient, safest and also the most economical method of drug delivery. Fast dissolving tablets are one such most advantageous example of the oral drug delivery. These tablets readily dissolve or disintegrate in the saliva i.e. within <60sec without the need for water. They have been formulated for pediatric, geriatric and bedridden patients. This type of dosage forms are also ideal for active patients who are busy and traveling and may not have access to water. FDTs have gained considerable attention for those patients who have difficulties in swallowing because of dysphagia, hand tremors problems and have additional advantage for unconscious, young patients with underdeveloped muscular and nervous system. This review describes the various advantages, limitations, desired characteristics, formulation aspects, super-disintegrants employed; technologies developed for FDTs, evaluation tests, and marketed formulations.

Mouth Dissolving Tablet: A Better Approach to Drug Delivery

Researchers throughout the world are focusing intensively on the methods for the development of new drug delivery systems to enhance patient's compliance. The oral route however still remained as the best administration route of therapeutic agents for its ease of ingestion, pain avoidance and versatility. Hence, fast dissolving tablets become an emerging trend in the pharmaceutical industry. Fast dissolving tablets are ideal for all types of people, including for people who have swallowing difficulties, paediatric, geriatric, and bedridden patients. It is also for active patients who are busy, travelling and may not have access to water. Fast dissolving tablets are also known as orodispersible tablets, mouth-dissolving tablets, orally disintegrating tablets, melt-in mouth tablets, rapimelts, porous tablets, quick dissolving etc. This type of tablets disintegrates quickly once introduced into the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. In this review article, drug candidates suitable for fast dissolving drug delivery and the available marketed products have been listed.