original ) (raw )Quantitative relationship between guanine O6-alkyl lesions produced by Onrigin™ and tumor resistance by O6-alkylguanine-DNA alkyltransferase
Kimiko Ishiguro
Biochemical Pharmacology, 2010
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Gene and human tumour cell line specific differencesin nitrogen mustard induced DNA alkylation and interstrand crosslinking frequencies
keith Grimaldi
Nucleic Acids Research, 1998
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Detection of sequence-specific antitumor alkylating agent DNA damage from cells treated in culture and from a patient
George Ogata
Cancer research, 1994
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DNA sequence selectivity of guanine–N7 alkylation by nitrogen mustards
kurt kohn
Nucleic Acids Research, 1986
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Effect of alkylating antitumor agents on the binding of DNA to protein
Jörg Schnierda
1973
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Alkylating agents and cancer therapy
Jatinder Kaur
2007
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Mutagenic and chemotherapeutic activity in L1210 leukemia of several monofunctional alkylating agents
Bipin Mehta
Cancer research, 1985
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1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O 6 -alkylguanine-DNA alkyltransferase in cytotoxicity
Krishnamurthy Shyam
Cancer Chemotherapy and Pharmacology, 2004
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Mechanism of H-ras Oncogene Activation in Mouse Squamous Carcinoma Induced by an Alkylating Agent1
Sy Garte
Cancer Research, 1988
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DNA damage and differential cytotoxicity produced in human carcinoma cells by CC-1065 analogues, U-73,975 and U-77,779
Neil Gibson
Cancer research, 1991
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In vitro cytotoxicity of GC sequence directed alkylating agents related to distamycin
Maurizio D'Incalci
Journal of Medicinal Chemistry, 1993
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Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones
S. Winski
Frontiers in Bioscience, 2000
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The Development of New DNA Alkylating Antitumour Agents Modeled on the Natural Product CC-1065
LEESA SWAN
2018
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The antitumour activity of alkylating agents is not correlated with the levels of glutathione, glutathione transferase and O6-alkylguanine-DNA-alkyltransferase of human tumour xenografts
Maurizio D'Incalci
European Journal of Cancer, 1998
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Changes in c-myc and c-fos Expression in a Human Tumor Cell Line following Exposure to Bifunctional Alkylating Agents1
Bernard Futscher
1990
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Mechanism of inhibition of DNA synthesis in Ehrlich ascites tumour cells by diazoacetyl glycine-amide
Tullio Giraldi
Biochemical Pharmacology, 1973
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Cytotoxicity of monofunctional alkylating agents. Methyl methanesulfonate and methyl-N'-nitro-N-nitrosoguanidine have different mechanisms of toxicity for 10T1/2 cells
Joe Grisham
Mutation research, 1983
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3-methyladenine-DNA-glycosylase and O6-alkyl guanine-DNA-alkyltransferase activities and sensitivity to alkylating agents in human cancer cell lines
Lorenzo Citti
British Journal of Cancer, 1996
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Mammalian 06-Alkylguanine-DNA Alkyltransferase: Regulation and Importance in Response to Alkylating Carcinogenic and Therapeutic Agents
Anthony Pegg
1990
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Comparison of DNA lesions produced by tumor-inhibitory 1,2-bis(sulfonyl)hydrazines and chloroethylnitrosoureas
Philip Penketh , Krishnamurthy Shyam
Biochemical Pharmacology, 2000
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DNA damage and sequence specificity of DNA binding of the new anti-cancer agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate)
kurt kohn
British journal of cancer, 1990
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Utilization of in vivo alkylated metabolites as a possible cause of increased sensitivity of tumor cells to alkylating agents
Michael Lerman
Molecular Biology Reports, 1975
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Human O6-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes
Lawrence Loeb
Carcinogenesis, 1999
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Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine
Andrew Povey
Mutagenesis, 2002
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Molecular Analysis of O6-Substituted Guanine-Induced Mutagenesis of ras Oncogenes
Ramesh Kumar
Proceedings of The National Academy of Sciences, 1989
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