The Role of Prostaglandin E Receptor Subtypes (EP1, EP2, EP3, and EP4) in Bone Resorption: An Analysis Using Specific Agonists for the Respective EPs
Yukihiko Sugimoto
Endocrinology, 2000
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Impaired Bone Resorption to Prostaglandin E2 in Prostaglandin E Receptor EP4-knockout Mice
Yukihiko Sugimoto
Journal of Biological Chemistry, 2000
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Prostaglandin Receptor EP4Mediates the Bone Anabolic Effects of PGE2
Michel Gallant
Molecular Pharmacology, 2001
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Prostaglandin E2 Directly Inhibits Bone-Resorbing Activity of Isolated Mature Osteoclasts Mainly Through the EP4 Receptor
M MANO
Calcified Tissue International, 2000
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A Nonprostanoid EP4 Receptor Selective Prostaglandin E2 Agonist Restores Bone Mass and Strength in Aged, Ovariectomized Rats
Kimberly Cameron
Journal of Bone and Mineral Research, 2005
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Systemic prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro
S. Keila
Journal of Endocrinology, 2001
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Impaired Bone Resorption by Lipopolysaccharide In Vivo in Mice Deficient in the Prostaglandin E Receptor EP4 Subtype
Yukihiko Sugimoto
Infection and Immunity, 2000
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Prostaglandin E2 (PGE2) increases the number of rat bone marrow osteogenic stromal cells (BMSC) via binding the EP4 receptor, activating sphingosine kinase and inhibiting caspase activity
S. Keila
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2006
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Discovery of CP533536: An EP 2 receptor selective prostaglandin E 2 (PGE 2) agonist that induces local bone formation
christina wright
Bioorganic & Medicinal Chemistry Letters, 2009
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Augmentation of bone morphogenetic protein-induced bone mass by local delivery of a prostaglandin E EP4 receptor agonist
Hidetomi Terai
Bone, 2005
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A prostanoid receptor EP4 agonist enhances ectopic bone formation induced by recombinant human bone morphogenetic protein-2
Hidetomi Terai
Biochemical and Biophysical Research Communications, 2004
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An EP2 receptor-selective prostaglandin E2 agonist induces bone healing
Bruce Lefker
Proceedings of the National Academy of Sciences, 2003
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Immunolocalization of the prostaglandin E2 receptor subtypes in human bone tissue: differences in foetal, adult normal, osteoporotic and pagetic bone
A. Brum-fernandes
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2004
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Prostaglandin E 2 Strongly Inhibits Human Osteoclast Formation
Nobuyuki Udagawa
Endocrinology, 2005
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A Novel, Non-Prostanoid EP2 Receptor-Selective Prostaglandin E2 Agonist Stimulates Local Bone Formation and Enhances Fracture Healing
Bruce Lefker
Journal of Bone and Mineral Research, 2003
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Inhibitory and stimulatory effects of prostaglandins on osteoclast differentiation
Afsie Sabokbar
Calcified Tissue International, 1997
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Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local upregulation of bone turnover in mature rats
Toshitaka Nakamura
Bone, 2004
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Effects of Basic Fibroblast Growth Factor and a Prostaglandin E2 Receptor Subtype 4 Agonist on Osteoblastogenesis and Adipogenesis in Aged Ovariectomized Rats
Marda Jorgensen
Journal of Bone and Mineral Research, 2007
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Systemic administration of an anabolic dose of PGE2 in young rats increases the osteogenic capacity of bone marrow
S. Keila
Bone, 1997
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Prostaglandin EP4 Selective Agonist AKDS001 Enhances New Bone Formation by Minimodeling in a Rat Heterotopic Xenograft Model of Human Bone
Zeynep Bal
Frontiers in Bioengineering and Biotechnology, 2022
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Effects of prostaglandins on rat calvarial bone-cell calcium
Rosemary Dziak
Archives of Oral Biology, 1984
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Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats
Margaret Chu-Moyer, Michael Zawistoski, Bruce Lefker, Kimberly Cameron
Bioorganic & Medicinal Chemistry Letters, 2006
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Prostaglandin E2 Stimulates Fibronectin Expression through EP1 Receptor, Phospholipase C, Protein Kinase Cα, and c-Src Pathway in Primary Cultured Rat Osteoblasts
Rong-sen Yang
Journal of Biological Chemistry, 2005
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Osteoblasts Are a New Target for Prolactin: Analysis of Bone Formation in Prolactin Receptor Knockout Mice 1
Brigitte Bouchard, Philippe Clément-lacroix
Endocrinology, 1999
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Osteoblasts are a new target for prolactin: Analysis of bone formation in prolactin receptor knockout mice
Vincent Goffin
Endocrinology
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Novel EP4 receptor agonist-bisphosphonate conjugate drug (C1) promotes bone formation and improves vertebral mechanical properties in the ovariectomized rat model of postmenopausal bone loss
JOHN GEORGIOU
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014
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Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism
Karolina Domaracka
Drug Design Development and Therapy, 2018
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Systemic effects of prostaglandin E2 on vertebral trabecular remodeling in beagles used in a healing study
Mei-Shu Shih
Calcified Tissue International, 1988
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Characterization of the prostaglandin receptors in human osteoblasts in culture
Ghassan Bkaily
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2001
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Regulation of bone biology by prostaglandin endoperoxide H synthases (PGHS): A rose by any other name…
Allison Pettit
Cytokine & Growth Factor Reviews, 2006
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Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture
Scott Morham
Journal of Clinical Investigation, 2000
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Prostaglandin E2 enhances alveolar bone formation in the rat mandible
Laurence Walsh
Bone, 2004
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Inactivation of estrogen receptor in bone-forming cells induces bone loss in female mice
kalman buki
The FASEB Journal, 2013
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Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in bone
Jono Yang
Journal of Endocrinology, 2007
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