Evaluation of Microcrystalline Cellulose Derived from Saccharum officinarum L. (Sugarcane) Leaves as a Disintegrant in Tablet Formulations (original) (raw)
Related papers
IJPSM, 2021
The aim of the study was to produce microcrystalline cellulose from Saccharumofficinarum and to evaluate its use as a disintegrant in metronidazole tablet formulation. Cellulose was produced and characterized. This was followed by a comparative characterization of the tablets formulated by using Saccharumofficinarummicrocrystalline cellulose (SO-MCC), maize starch and crosscarmellose sodium (Ac-di-sol®) as disintegrants. The granules were evaluated for flow properties and the tablet evaluated for hardness, friability, disintegration and dissolution properties. For disintegration studies, the disintegrants disintegrated within 10 minutes in this order: Ac-di-sol® >SO-MCC>Maize starch. All the tablets exhibited high release profile which conformed to British Pharmacopoeia standards. Hence, SO-MCC can be used as an alternative disintegrant in terms of cost and availability.
Journal of Characterization
This study was aimed at preparation and comparison of the physiochemical properties of a locally prepared microcrystalline cellulose obtained from dried stem pulp chips of sugarcane (Saccharum officinarum) coded SO-MCC and compared with a commercial grade (Avicel PH 102). SO-MCC was prepared from-cellulose derived by alkaline hydrolysis from dried sugarcane stem chips, bleached with sodium hypochlorite and treated with 2.5N hydrochloric acid. The MCC were identified by BP (2009) method. The comparative physicochemical properties evaluated include: DSC, pH, mean particles diameter, true, bulk and tapped densities, angle of repose, Hausner's quotient, compressibility index, porosity, hydration, swelling and moisture sorption capacities. The results obtained from these tests are: pH (7.5), mean particle diameter (239), true, bulk and tapped densities (1.54, 0.464, 0.617), angle of repose (34.70), Hausner's quotient (1.32), C.I (25.00), porosity (70.00), hydration, swelling and moisture sorption capacities (4.00, 47.16, 21.30). The DSC showed a sharp peak at 730C which depicts high purity. Both MCCs showed the same organoleptic properties, similar DSC and also had poor flowability. Overall, the results indicated that SO-MCC compared favourably with commercial grade Avicel PH 102 in terms of its physicochemical properties and complied with British Pharmacopoeia specifications for microcrystalline cellulose.
Physical and mechanical properties of microcrystalline cellulose prepared from agricultural residues
Carbohydrate Polymers, 2007
Microcrystalline cellulose (MCC) was prepared from local agricultural residues, namely, bagasse, rice straw, and cotton stalks bleached pulps. Hydrolysis of bleached pulps was carried out using hydrochloric or sulfuric acid to study the effect of the acid used on the properties of the produced microcrystalline cellulose such as degree of polymerization (DP), crystallinity index (CrI), crystallite size, bulk density, particle size, and thermal stability. The mechanical properties of tablets made from microcrystalline cellulose of different agricultural residues were tested and compared to a commercial-grade MCC. The use of rice straw pulp in different proportions as a source of silica to prepare silicified microcrystalline cellulose (SMCC) was investigated. The effect of the percent of rice straw added on the mechanical properties of tablets before and after wet granulation was studied.
Evaluation of several microcrystalline celluloses obtained from agricultural by-products
Journal of advanced pharmaceutical technology & research, 2011
Microcrystalline cellulose (MCCI) has been widely used as an excipient for direct compression due to its good flowability, compressibility, and compactibility. In this study, MCCI was obtained from agricultural by-products, such as corn cob, sugar cane bagasse, rice husk, and cotton by pursuing acid hydrolysis, neutralization, clarification, and drying steps. Further, infrared spectroscopy (IR), X-ray diffraction (XRD), optical microscopy, degree of polymerization (DP), and powder and tableting properties were evaluated and compared to those of Avicel PH101, Avicel PH102, and Avicel PH200. Except for the commercial products, all materials showed a DP from 55 to 97. Particles of commercial products and corn cob had an irregular shape, whereas bagasse particles were elongated and thick. Rice and cotton particles exhibited a flake-like and fiber-like shape, respectively. MCCI as obtained from rice husk and cotton was the most densified material, while that produced from corn cob and ba...
Indonesian Journal of Pharmaceutics, 2021
Microcrystalline cellulose was isolated from rami (Boehmeria Nivea L. Gaud), and applied as disintegrant in tablets of dimenhydrinate, made by direct compression and wet granulation. The aim of this study is to produce dimenhydrinate tablets with Microcrystalline Cellulose Rami (MCC Rami) isolated from Rami (Boehmeria Nivea L. Gaud), as a disintegrant and assess the effect of MCC Rami and Granulation technique on physical properties of drug such as, disintegration time, drug release and dissolution. Formulations of dimenhydrinate 100mg tablets were prepared with a combination of mannitol and lactose as a filler and MCC Rami as disintegrant in a concentration of 10-20%. The formulas were directly compressed or were compressed into tablets after wet granulation. The mechanical properties, drug release, physical properties and effects of process parameters, methods of applying disintegrant in tablet formulas were examined. A significant difference in disintegration time of tablets that...
IOP Conference Series: Earth and Environmental Science, 2020
Saccharum officinarum L. bagasse is waste from sugarcane plants contains lignin, hemicellulose, cellulose and wax compounds. Isolation of cellulose from sugarcane can be done by acid hydrolysis of sugarcane waste and delignification with Sodium Hydroxide (NaOH). The objectives of this research were to study the effect of acid type and concentration on the physical and chemical characteristics of cellulose isolated from sugarcane bagasse. The acid variation that used were nitric acid: sulphuric acid; nitric acid; hydrochloric acid and sulphuric acid: hydrochloric acid in 1:1; 2:1 and 3:1 in the variation of concentration for each combination. Cellulose characteristics observed were color, shape and powder properties such as Hausner Ratio, Carr’s index, Angle of Repose and functional group analysis of cellulose using FTIR (Fourier Transform Infrared). The cellulose that isolated from sugarcane bagasse with HNO3: H2SO and HNO3: HCl were matched in white powder form with standard cellul...
Carbohydrate Polymers, 2011
Microcrystalline cellulose (MCC) Rice hulls Bean hulls Scanning electron microscopy (SEM) Infrared spectroscopy (FTIR) Thermogravimetry analysis (TGA) and X-ray diffraction a b s t r a c t Microcrystalline cellulose (MCC) is a very important product in pharmaceutics, foods, cosmetics and other industries. In this work, MCC was prepared from rice and bean hulls (RH and BH). Hydrolysis of bleached pulps was carried out using hydrochloric or sulfuric acid to study the effect of the acid used on the properties of the produced MCC. MCC samples prepared from RH and BH were characterized through various techniques, scanning electron microscopy (SEM), infrared spectroscopy (FTIR), thermogravimetry analysis (TGA) and X-ray diffraction and compared with commercial MCC. The mechanical properties of tablets made from MCC of different lignocellulosic materials were tested and compared to a commercial MCC.
Journal of Drug Delivery and Therapeutics, 2018
Microcrystalline cellulose (MCC) derived from Saccharum officinarum stem was evaluated for its powder flow and compaction properties in order to assess its suitability as a potential direct compression excipient in tablet formulations. Alpha (α) cellulose obtained from different sodium hydroxide and bleaching treatments of dried shred S. officinarum stem pulp was hydrolyzed with 2.5 N hydrochloric acid (2.5 N HCl) to obtain MCC which was coded MCC-Sacc. This was compared with a commercial brand, Avicel PH 102. The results of powder flow parameters such as bulk, tapped and particle densities (0.41 ± 0.01, 0.54 ± 0.01 and 1.52 ± 0.10 g/mL respectively), porosity (78.69 ± 0.20 %), Carr's index (31.47 ± 0.75 %), Hausner's quotient (1.47) and angle of repose (31.00 ± 1.00 °) indicate poor flowability. Kawakita model assessment of powder showed good densification and cohesiveness. Compacts of MCC-Sacc showed good uniformity of weight, friability, disintegration and mechanical strength. The Heckel model showed good plasticity and slippage of the material. Values obtained were comparable to Avicel PH 102 in terms of compressibility and mechanical strength, hence MCC-Sacc has a good potential for use as a pharmaceutical excipient in the direct compression method of tablet formulation.
Preparation & Characterization of Microcrystalline Cellulose from Agriculture Waste
IOP Conference Series: Earth and Environmental Science, 2020
In this work, microcrystalline cellulose was prepared from oil palm trunk by water treated fibre process and alkali bleaching. The prepared samples were characterized by using Fourier-transform infrared spectroscopy attenuated total reflectance (FTIR-ATR), Scanning Electron Microscopy (SEM) and X-ray diffraction (XRD). FTIR-ATR spectra analysis indicates the presence of the hydroxyl group, alcohol, alkane/alkene and imine group. XRD patterns revealed the amorphous nature of the samples and the crystallinity index for extracted cellulose is 48.7 %. SEM images showed the fibrous structure of the microcrystalline cellulose with a size of 50 μm. This research proved that the synthesized microcrystalline cellulose could be potentially used as reinforcement in bio composite for better performance and ductility.
Polímeros
Microcrystalline cellulose synthesized from the waste of Musa balbisiana (BMCC) was characterized to explore the possibility of application in the pharmaceutical industry especially as a drug delivery vehicle. The SEM, XRD and FTIR investigations revealed that the predominantly short, non-aggregated and irregular MCC rods were highly crystalline. The moisture sorption value for BMCC was 5.65%, while total ash was 0.39%. Flow of BMCC was poor, but the product exhibited high hydration (11.7%) and swelling (277.0%) capacities. Preliminary investigation of BMCC tablets containing ascorbic acid carried out in simulated intestinal fluid, showed a concentration dependent retardation of drug release. No cytotoxicity of BMCC was observed in the hemolytic assay. Overall, the study revealed that BMCC can be prepared from an inexpensive and abundant agricultural waste and possesses properties advantageous for application in the pharmaceutical industry and may be explored further in drug delivery research.