“Synthesis, Characterization and Biological Importance of Inner Transition Metal complexes of Schiff base Benzilmonoximethiocarbohydrazide derivative”: a Review (original) (raw)
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Pakistan journal of pharmaceutical sciences, 2019
A new series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes with a novel Schiff base were synthesized by the condensation of sulphadizine and thiophene-2-carbaldehyde.The ligand and its complexes were characterized by using diverse instrumental procedures like microanalysis, thermo gravimetric examination and spectroscopy. The integrated ligand and its metal complexes were subjected to antibacterial studies. These studies demonstrated the enhanced activity of metal complexes against reported microbes with respect to the Schiff base.
Performance of Schiff Bases Metal Complexes and their Ligand in Biological Activity: A Review
Al-Nahrain Journal of Science, 2021
Schiff bases are a broad class synthesized compound, which is prepared for the condensation process between the primary amine group and an aldehyde or ketone group. Schiff base metal complexes play an important role in many applications such as biological activity, catalytic activity, and optical property. The wide range application of Schiff base metal complexes came from the versatility of Schiff base reactions with many different transition metals. This flexibility of the reactions was given these complexes, many different properties and uses in a biological human system such as antibacterial, antifungal, anticancer, antimalarial, and others. This review gives many examples of Schiff bases, metal complexes, and there ligands with biological applications in the human system.
Application of Metal Complexes of Schiff Bases as an Antimicrobial Drug: A Review of Recent Works
International Journal of Current Pharmaceutical Research
Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Synthesis of Schiff base transition metal complexes by using Schiff base as ligands appears to be fascinating in view of the possibility of obtaining coordination compounds of unusual structure and stability. These transition metal complexes have received exceptional consideration because of their active part in metalloenzymes and as biomimetic model compounds due to their closeness to natural proteins and enzymes. These compounds are very important in pharmaceutical fields because of their wide spectrum of biological activities. Most of them show biological activities including antibacterial, antifungal, antidiabetic, antitumor, antiproliferative, anticancer, herbicidal, and anti-inflammatory activities. The biological activity of the transition metal complexes derived from the Schiff base ligands has been widely studied. This review summarizes the importance, Scop...
Biological Activities of Metal Complexes of Schiff Bases -A Review
Schiff bases have ability to form complexes with transition and inner transition metals and therefore regarded as very important class of organic compounds. Schiff bases serve as special ligands because they are readily synthesized by condensation reactions of aldehyde derivatives with imines. However their production is simple, their modest manufacturing technology and wide range of applications in areas such as coordination chemistry, analytical chemistry, catalysis and medicinal chemistry make them unique compounds. Various bioactivities such as anticancer, antineoplastic, analgesic, antifungal, antiviral, antioxidant, antibacterial, antipyretic, antiproliferative and anti-inflammatory etc. of schiff bases and their metal complexes are being studied. This review highlights synthesis as well as biological applications of various schiff bases and their metal complexes.
Applied Sciences
Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.
Synthesis and bioactivity studies of novel Schiff bases and their complexes
Journal of Physical Organic Chemistry, 2019
The new Schiff base (L) "4-[(2,4-dimethoxy-benzylidene)-amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one" was synthesized from 2,4-dimethoxybenzaldehyde and 4-amino-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one, and the geometry of Schiff base was characterized and determined by proton nuclear magnetic resonance (1 H-NMR), mass, Fourier transform infrared (FT-IR), and ultraviolet-visible (UV-vis) spectroscopy. Schiff complexes of Ni(II), Pd(II), Pt(IV), Zn(II), Cd(II), and Mg(II) have been prepared by reaction of ion metals with as-prepared Schiff base. The results showed that synthesized complexes offered 1:2 metal-ligand ratios. Furthermore, the Schiff complexes were a tetrahedral in complexes Ni(II), Zn(II), Cd(II), and Hg(II), octahedral Pt(II), and square planer complex Pd(II). Additionally, density functional theory (DFT) was applied for calculations of both spectroscopic properties and electronic structure of prepared Schiff bases. Moreover, the Schiff base and its metal complexes have been verified in vitro against Streptococcus, Esherichia coli, Candida albicans, and Candida tropicalis in order to assess their antibacterial potential. The findings indicate that the biological activity augments on complexation reaction.
Metal complexes of some transition metal ions viz Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) have been synthesized from a Schiff base (L) formed by the condensation of 3-amino-5-bromobenzofuran-2-carboxamide and 2-hydroxy-1-napthaldehyde. Synthesized compounds have been studied by various spectroscopic techniques and evaluated for their DNA cleavage and antimicrobial activities. Antibacterial activities of ligand and its metal complexes have shown that the metal complexes are more active than their corresponding ligand.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2014
Present work reviews that, the synthesis of (E)-N'-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)benzohydrazide [L] ligand and their metal complexes. The colored complexes were prepared of type [M(2+)L]X2, where M(2+)=Mn, Co, Ni, Cu, Sr and Cd, L=(7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)benzohydrazide, X=Cl(-). Ligand derived from the condensation of 8-formyl-7-hydroxy-4-methylcoumarin and benzohydrazide in the molar ratio 1:1 and in the molar ratio 1:2 for metal complexes have been prepared. The chelation of the ligand to metal ions occurs through the both oxygen groups, as well as the nitrogen atoms of the azomethine group of the ligand. Reactions of the Schiff base ligand with Manganese(II), Cobalt(II), Nickel(II), Copper(II), Strontium(II), and Cadmium(II) afforded the corresponding metal complexes. The structures of the obtained ligand and their respective metal complexes were elucidated by infra-red, elemental analysis, Double beam UV-visible spectra, con...
Oriental Journal Of Chemistry
Schiff based ligands and their complexes have emerged as potential drug candidates. Owing to their excellent chelating tendency, they easily coordinate with transition metals which have vacant orbitals. Transition metal complexes have several advantages because of their better acceptability and low toxicity in biological systems. These metals also serve as micronutrients and as co-factors of various metallo-enzymes which justifies the need of their designing and synthesis. Many modifications have been suggested in the ligand moiety for the purpose of activity enhancement and some of them have been described in the present review. These modifications have enhanced better potency against a number of diseases and resulting in low toxicity and better solubility in vivo. The transition metal complexes with Schiff based complexes have exhibited an array of activities including anticancer, antioxidant and antimicrobial. Their analytical applications have also been reported. The present rev...