Chemical markers for the quality control of herbal medicines: an overview (original) (raw)
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Chinese Medicine Chemical markers for the quality control of herbal medicines: an overview
Selection of chemical markers is crucial for the quality control of herbal medicines, including authentication of genuine species, harvesting the best quality raw materials, evaluation of post-harvesting handling, assessment of intermediates and finished products, and detection of harmful or toxic ingredients. Ideal chemical markers should be the therapeutic components of herbal medicines. However, for most herbal medicines, the therapeutic components have not been fully elucidated or easily monitored. Bioactive, characteristic, main, synergistic, correlative, toxic and general components may be selected. This article reviews the effective use of chemical markers in the quality control of herbal medicines including the selection criteria considering the roles and physicochemical factors which may affect the effective use of chemical markers.
Chemical marker compounds and their essential role in quality control of herbal medicines
2012
Many countries are registering their standardized herbal drugs with proven clinical efficacy, safety and as dietary supplements. But India is unable to exploit the World market due to unsatisfactory system of quality control which necessitates the establishment of standards for herbal single drugs and compound formulations. In order to ensure international community to use AYUSH drugs with confidence and without compunction, developing acceptable quality control standards of herbal medicines aims to ensure their consistency, safety and efficacy with good manufacturing practices is very much essential. Study of chemical markers is applicable to many research areas, including authentication of genuine species, search for new resources or substitutes of raw materials, optimization of extraction and purification methods, structure elucidation and purity determination. Systematic investigations using chemical markers may lead to discoveries and development of new drugs.
Quality control of herbal medicines
Journal of Chromatography B, 2004
Different chromatographic and electrophoretic techniques commonly used in the instrumental inspection of herbal medicines (HM) are first comprehensively reviewed. Chemical fingerprints obtained by chromatographic and electrophoretic techniques, especially by hyphenated chromatographies, are strongly recommended for the purpose of quality control of herbal medicines, since they might represent appropriately the "chemical integrities" of the herbal medicines and therefore be used for authentication and identification of the herbal products. Based on the conception of phytoequivalence, the chromatographic fingerprints of herbal medicines could be utilized for addressing the problem of quality control of herbal medicines. Several novel chemometric methods for evaluating the fingerprints of herbal products, such as the method based on information theory, similarity estimation, chemical pattern recognition, spectral correlative chromatogram (SCC), multivariate resolution, etc. are discussed in detail with examples, which showed that the combination of chromatographic fingerprints of herbal medicines and the chemometric evaluation might be a powerful tool for quality control of herbal products.
Role of markers in the standardization of herbal drugs: a review
Archives of Applied Science Research, 2010
The efficacy and safety of any pharmaceutical product is determined by the compounds (desired and undesired) which it contains. The purpose of quality control is to ensure that each dosage unit of the drug product delivers the same amount of active ingredients and is, as far as possible, free of impurities. As herbal medicinal products are complex mixtures which originate from biological sources, great efforts are necessary to guarantee a constant and adequate quality. By carefully selecting the plant material and a standardized manufacturing process the pattern and concentration of constituents of herbal medicinal products should be kept as constant as possible as this is a prerequisite for reproducible therapeutic results.
Quality control of the traditional herbs and herbal products: a review
Future Journal of Pharmaceutical Sciences
Background Herbal medicinal material and product need is increasing, and with this increase in the need, it is very much an essential requirement to maintain the quality of them. Main body The quality of the herbals is altered by various physical, chemical, and geographical aspects which contribute to the quality of these materials. Apart from that, adulteration is also an increasing concern when it comes to herbal material quality. Various chemical and phytochemical test, analytical techniques, and hyphenated analytical techniques are used for determining the quality aspects of the herbal materials in the herbal pharmaceuticals. Conclusion These techniques can be used as quality control tool in assessing the quality of herbal materials and herbal pharmaceuticals.
Standardization, evaluation and quantification of herbal drugs by various analytical methods
International Journal of Ayurvedic Medicine
This review article encompasses the various evaluation parameters of standardization of different medicinal plants and its constituents. In today’s life, more and more people of the world are turning towards the use of natural or herbal products as these have very less or negligible side effects. As the use of herbal medicinal products is increasing day by day, the questions regarding their quality are also arising. This is due to lack of parameters for the standardization of these products. There is a need to set different parameters or methods that can help to standardize the herbal medicinal plant materials. Various methods like physical, chemical, biological is used for standardization and quality evaluation of herbal medicinal plants. These methods can act as a basic tool for the quality evaluation of herbal plant materials. Different parameters of standardization are the fundamental tool for evaluating and assuring the quality of the herbal plant material and its products. Thi...
Quality Aspects of Herbal Drugs
The safety and efficacy of the herbal medicine is based on their quality. As there is growing demand of herbal medicines, there is a need to assure their quality. Near about 80% of the population is depending on the herbal drugs for the prevention, cure, and treatment of disease, therefore to maintain the quality of herbal drugs is vital element. So the different chemical, phytochemical tests, analytical techniques are used for determining the quality aspects of the herbal materials in the herbal pharmaceuticals. The present review is focused on the various quality control tests for herbal drugs such as organoleptic evaluation, chemical evaluation, foreign matter, stability determination, analytical evaluation, etc. we have also discussed the benefits of quality control of herbal medicines. This will assist in maintaining the quality standards of the herbal drugs, which is the challenging task and need of the moment in the quality assurance and pharmaceutical research.
Quality Control and Evaluation of Herbal Product
International Journal for Research in Applied Science & Engineering Technology (IJRASET), 2023
Standardization of herbal formulation is important in order to assess of quality drug. The quality of herbal drug is the considerate all the factor which contribute directly or indirectly to the safety, effectiveness of the product Medicinal plant have been used to improve human health , increasing popularity global as drug , complementary and alternative medicines, food supplement, cosmetic as medical devices. The complexity of herbs and extracts supplied to such a wide range of markets and in different requlatory environment, raise major quality issues, increasing the need for appropriate analytical method for their identification, standardization &also for the detection of adulterants and contamination. Major limitation factors, such as herbal product naming, sampling and sample preparation are also discussed. The use of products of natural origin has remarkably increased in the global market, because of consumer becoming more health-conscious herbal medicines are considered safe by consumers and these product are generally less expensive than allopathic medicines.
Application of Quality Control Principles to Herbal Drugs
International Journal of Phytomedicine, 2009
Quality is conformance to requirement and meeting stated as well as implied needs of customer. The word quality is derived from Latin 'qualis' means 'of what kind' and encompasses composition and properties of object. Quality is of paramount importance when it is specifically related with drugs. And when it comes to herbal drugs, because of several reasons is a herculean task. The quality of pharmaceuticals has been a concern of the World Health Organization (WHO) since its inception. The setting of global standards is requested in Article 2 of the WHO Constitution, which cites as one of the Organization's functions that it should "develop, establish and promote international standards with respect to food, biological, pharmaceutical and similar products". The World Health Assembly-in resolutions WHA31.33 (1978), WHA40.33 (1987) and WHA42.43 (1989)-has emphasized the need to ensure the quality of medicinal plant products by using modern control techniques and applying suitable standards. This manual describes a series of tests for assessing the quality of medicinal plant materials. The tests are designed primarily for use in national drug quality control laboratories in developing countries, and complement those described in 'The international pharmacopoeia' which provides quality specifications only for the few plant materials that are included in the WHO 'Model List of Essential Drugs'. In this review, we have addressed some important issues related to quality of botanicals and discussed possible application of total quality management for herbal drugs.
PLOS ONE, 2016
The use of botanical medicine by practitioners and the general public has dramatically increased in recent years. Most of these botanical therapeutics are obtained through commercial manufacturers or nutraceutical companies. The current standard of practice that manufacturers typically use to standardize botanicals is done based on the level of a wellknown, abundant marker compound present in the botanical. This study evaluated the putative correlation between the level of a marker compound and the biological activity of eight common botanicals. Overall, the standardization of a botanical based on a marker compound was found not to be a reliable method when compared to in vitro bioactivity. A marker compound is often not the biologically active component of a plant and therefore the level of such a marker compound does not necessarily correlate with biological activity or therapeutic efficacy.