original ) (raw )Processing sites in the human immunodeficiency virus type 1 (HIV1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates
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Initial Cleavage of the Human Immunodeficiency Virus Type 1 GagPol Precursor by Its Activated Protease Occurs by an Intramolecular Mechanism
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Journal of Virology, 2004
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Ordered Processing of the Human Immunodeficiency Virus Type 1 GagPol Precursor Is Influenced by the Context of the Embedded Viral Protease
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Journal of Virology, 2005
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Naturally Occurring Amino Acid Polymorphisms in Human Immunodeficiency Virus Type 1 (HIV-1) Gag p7NC and the C-Cleavage Site Impact Gag-Pol Processing by HIV-1 Protease
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Virology, 2002
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The Initial Step in Human Immunodeficiency Virus Type 1 GagProPol Processing Can Be Regulated by Reversible Oxidation
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PLoS ONE, 2010
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Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors
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The Journal of biological chemistry, 2002
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Altered Gag Polyprotein Cleavage Specificity of Feline Immunodeficiency Virus/Human Immunodeficiency Virus Mutant Proteases as Demonstrated in a Cell-Based Expression System
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Journal of Virology, 2006
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Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor
Thomas Meek
Proceedings of the National Academy of Sciences, 1987
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HIV-1 Gag Processing Intermediates Trans-dominantly Interfere with HIV-1 Infectivity
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Journal of Biological Chemistry, 2009
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Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959
Jan Mous
Virology, 1995
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Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions
Charles Craik
The Journal of biological chemistry, 1993
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Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity
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Retrovirology, 2012
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The role of lysine residue at amino acid position 165 of human immunodeficiency virus type 1 CRF01_AE Gag in reducing viral drug susceptibility to protease inhibitors
Kenzo Tokunaga
Virology, 2010
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The virus-associated human immunodeficiency virus type 1 Gag-Pol carrying an active protease domain in the matrix region is severely defective both in autoprocessing and in trans processing of gag particles
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Virology, 2004
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Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor
M. El-Farrash
Journal of Virology, 1994
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Role of the Matrix-Capsid Cleavage Site Polymorphism S124V of HIV-1 Sub-subtype A2 in Gag Polyprotein Processing
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2020
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Comparison of Human Immunodeficiency Virus Type 1 Pr55 Gag and Pr160 Gag-Pol Processing Intermediates That Accumulate in Primary and Transformed Cells Treated with Peptidic and Nonpeptidic Protease Inhibitors
Richard Collins III
Antimicrobial Agents and Chemotherapy, 2000
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Natural Variation in HIV1 Protease, Gag p7 and p6, and Protease Cleavage Sites within Gag/Pol Polyproteins: Amino Acid Substitutions in the Absence of Protease Inhibitors in Mothers and Children Infected by Human Immunodeficiency Virus Type 1
Elena Perez
Virology, 1996
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Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease
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Amino Acid Preferences of Retroviral Proteases for Amino-Terminal Positions in a Type 1 Cleavage Site
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Mutational Analysis of the C-Terminal Gag Cleavage Sites in Human Immunodeficiency Virus Type 1
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Journal of Virology, 2007
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Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites
Irene Weber
European Journal of Biochemistry, 2002
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Drug-associated changes in amino acid residues in Gag p2, p7 NC, and p6 Gag/p6 Pol in human immunodeficiency virus type 1 (HIV1) display a dominant effect on replicative fitness and drug response
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Virology, 2008
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HIV-1 Protease Catalytic Efficiency Effects Caused by Random Single Amino Acid Substitutions
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Molecular Biology and Evolution, 2006
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Active human immunodeficiency virus protease is required for viral infectivity
Emilio Emini
Proceedings of the …, 1988
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Mutational Analysis of the Substrate Binding Pocket of Murine Leukemia Virus Protease and Comparison with Human Immunodeficiency Virus Proteases
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Activity of Tethered Human Immunodeficiency Virus 1 Protease Containing Mutations in the Flap Region of One Subunit
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European Journal of Biochemistry, 1997
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Perspectives in Drug Discovery and Design, 1993
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Local and spatial factors determining HIV-1 protease substrate recognition
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