Active human immunodeficiency virus protease is required for viral infectivity (original) (raw)
Positive and Negative Aspects of the Human Immunodeficiency Virus Protease: Development of Inhibitors versus Its Role in AIDS Pathogenesis
Ronald Luftig
Microbiology and Molecular Biology Reviews, 2000
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Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation
Charles Craik
Proceedings of the National Academy of Sciences, 1995
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Inhibition of HIV by an anti-HIV protease synthetic peptide blocks an early step of viral replication
Jean-alain Fehrentz
Research in Virology, 1992
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Partial purification and substrate analysis of bacterially expressed HIV protease by means of monoclonal antibody. EMBO J 7: 1785-1791
Dr. Susanne Billich
The EMBO Journal
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Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease
Thomas Meek
Proceedings of the National Academy of Sciences, 1989
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Partial purification and substrate analysis of bacterially expressed HIV protease by means of monoclonal antibody
Dr. Susanne Billich
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Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor
Thomas Meek
Proceedings of the National Academy of Sciences, 1987
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HIV protease as a target for retrovirus vector-mediated gene therapy
Charles Craik
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000
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Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor
M. El-Farrash
Journal of Virology, 1994
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Increased expression and immunogenicity of HIV-1 protease following inactivation of the enzymatic activity
Anna-Karin Maltais
Vaccine, 2011
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Removal of human immunodeficiency virus type 1 (HIV-1) protease inhibitors from preparations of immature HIV-1 virions does not result in an increase in infectivity or the appearance of mature morphology
TOMINAGA FUKAZAWA
Antimicrobial Agents and Chemotherapy, 1997
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Amino acid insertions at position 35 of HIV-1 protease interfere with virus replication without modifying antiviral drug susceptibility
B. Fausto
Antiviral Research, 2006
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Mutational Analysis of the Substrate Binding Pocket of Murine Leukemia Virus Protease and Comparison with Human Immunodeficiency Virus Proteases
Irene Weber, Alexander Wlodawer
Journal of Biological Chemistry, 1995
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Characterization of the murine leukemia virus protease and its comparison with the human immunodeficiency virus type 1 protease
Irene Weber
Journal of General Virology, 2006
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Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions
Charles Craik
The Journal of biological chemistry, 1993
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HIV Protease: Historical Perspective and Current Research
Robert Harrison
Viruses
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Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1
Olivier Schwartz
Journal of virology, 1998
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Catalytic efficiency and vitality of HIV1 proteases from African viral subtypes
sonia vega
Proceedings of The National Academy of Sciences, 2001
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Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease
Steve Pettit
Journal of Virology, 2002
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Establishment of a biological assay system for human retroviral protease activity
ahmad piroozmand
Microbes and Infection, 2005
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Conversion of Thymidylate Synthase into an HIV Protease Substrate
Pierre SONIGO
Journal of Biological Chemistry, 1996
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Structure of the protease from simian immunodeficiency virus: Complex with an irreversible nonpeptide inhibitor
Charles Craik
Biochemistry, 1993
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Human immunodeficiency virus type 1 Vif binds the viral protease by interaction with its N-terminal region
marina hutoran
The Journal of general virology, 2002
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The 80's loop (residues 78 to 85) is important for the differential activity of retroviral proteases
Mike Tennant
Journal of Molecular Biology, 1997
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Comparison of Human Immunodeficiency Virus Type 1 Pr55 Gag and Pr160 Gag-Pol Processing Intermediates That Accumulate in Primary and Transformed Cells Treated with Peptidic and Nonpeptidic Protease Inhibitors
Richard Collins III
Antimicrobial Agents and Chemotherapy, 2000
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The HIV-1 protease substitution K55R: a protease-inhibitor-associated substitution involved in restoring viral replication
Michael Maguire
Journal of Antimicrobial Chemotherapy, 2008
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Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation
Charles Craik
Antimicrobial Agents and Chemotherapy, 1994
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Selective and facile assay of human immunodeficiency virus protease activity by a novel fluorogenic reaction
Kaio Kitazato
Analytical Biochemistry, 2010
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Altered Gag Polyprotein Cleavage Specificity of Feline Immunodeficiency Virus/Human Immunodeficiency Virus Mutant Proteases as Demonstrated in a Cell-Based Expression System
Ashraf Brik
Journal of Virology, 2006
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Inhibition of Cytokine‐Driven Human Immunodeficiency Virus Type 1 Replication by Protease Inhibitor
Kenneth Roebuck
The Journal of Infectious Diseases, 1997
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Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959
Jan Mous
Virology, 1995
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Proteolytic activity in vivo and encapsidation of recombinant human immunodeficiency virus type 1 proteinase expressed in baculovirus-infected cells
Bernard Gay
The Journal of general virology, 1997
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The specificity of the HIV1 protease
Steve Pettit
Perspectives in Drug Discovery and Design, 1993
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How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity
G. Schmidtke
Journal of Biological Chemistry, 1999
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