The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter (original) (raw)
Interference of Glycine Transporter 1: Modulation of Cognitive Functions Via Activation of Glycine-B Site of the NMDA Receptor
Benjamin K Yee
Central Nervous System Agents in Medicinal Chemistry, 2007
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Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression
Daniela Alberati
Neuroscience Letters, 2004
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Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo
Long Chen
Journal of neurophysiology, 2003
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Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels
Marzia Martina
Journal of Physiology-london, 2004
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Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion
Beatriz López-Corcuera
Trends in Pharmacological Sciences, 2005
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Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions
Gerd Dannhardt
European Journal of Medicinal Chemistry, 2003
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Glycine Site Agonists of the NMDA Receptor: A Review
John Krystal
CNS Drug Reviews, 1995
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Effects of RPR 118723, a novel antagonist at the glycine site of the NMDA receptor, in vitro
Carole Monterrat
European Journal of Pharmacology, 2000
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Characterization of a novel putative cognition enhancer mediating facilitation of glycine effect on strychnine-resistant sites coupled to NMDA receptor complex
Marcos Lanza
Neuropharmacology, 1997
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Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites
Papangelis Athanasios
ACS chemical neuroscience, 2017
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Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia☆
Guy Griebel
Pharmacology Biochemistry and Behavior, 2008
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Characterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: evidence for two pharmacological classes of antagonists
Anne Stephenson
British Journal of Pharmacology, 2000
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Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile
Benjamin K Yee
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006
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Gene knockout of glycine transporter 1: Characterization of the behavioral phenotype
Marzia Martina
Proceedings of The National Academy of Sciences, 2004
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The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia
Joseph T Coyle
Psychopharmacology, 2004
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Glycine-dependent activation of NMDA receptors
Gabriela K Popescu
The Journal of general physiology, 2015
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Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP
graham collingridge
Neuroscience Letters, 1990
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Localization of the GLYT1 Glycine Transporter at Glutamatergic Synapses in the Rat Brain
F. Zafra
Cerebral Cortex, 2005
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Blockade of glycine transporter 1 by SSR504734 promotes cognitive flexibility in glycine/NMDA receptor-dependent manner
Dominik Rafa
Neuropharmacology, 2011
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Molecular biology of glycinergic neurotransmission
F. Zafra
Molecular Neurobiology, 1997
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The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine
Krzysztof Hyrc
The Journal of Physiology, 2009
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Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential
Daniela Alberati
Pharmacology Biochemistry and Behavior, 2010
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Novel systemically-active antagonists of the glycine site of the NMDA receptor - behavioural characterisation
Wojciech Danysz
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Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses
Stéphane Dieudonné, Philippe Ascher
Journal of neurophysiology, 1998
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Neurotransmitters: NMDA receptors: do glia hold the key?
Stuart Cull-candy
Current Biology, 1995
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Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site
Gerhard Trube, Vincent Mutel
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
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Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level
Joseph T Coyle
Nature Communications, 2013
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Glycine site associated with the NMDA receptor modulates long-term potentiation
Frank Schottler
Synapse, 1990
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Novel systemically active antagonists of the glycine site of NMDA receptor - behavioural characterisation
Wojciech Danysz
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