Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin (original) (raw)

Profile image of Carmen Méndez Carmen Méndez

1999, Chemistry & Biology

The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin

View PDFchevron_right

Elucidation of the Glycosylation Sequence of Mithramycin Biosynthesis: Isolation of 3A-Deolivosylpremithramycin B and Its Conversion to Premithramycin B by Glycosyltransferase MtmGII

ChemBioChem, 2005

View PDFchevron_right

Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin

Microbial Cell Factories, 2020

View PDFchevron_right

Ketopremithramycins and Ketomithramycins, Four New Aureolic Acid-Type Compounds Obtained upon Inactivation of Two Genes Involved in the Biosynthesis of the Deoxysugar Moieties of the Antitumor Drug Mithramycin by Streptomyces A rgillaceus , Reveal Novel Insights into Post-PKS Tailoring Steps of t...

Jose Garcia-bernardo, Daniel Bearden, Alfredo Braña

Journal of the American Chemical Society, 2002

View PDFchevron_right

Generation of New Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation Pattern through Combinatorial Biosynthesis

ChemBioChem, 2008

View PDFchevron_right

Cooperation of Two Bifunctional Enzymes in the Biosynthesis and Attachment of Deoxysugars of the Antitumor Antibiotic Mithramycin**

View PDFchevron_right

Premithramycinone G, an Early Shunt Product of the Mithramycin Biosynthetic Pathway Accumulated upon Inactivation of Oxygenase MtmOII

Angewandte Chemie International Edition, 2006

View PDFchevron_right

Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin

Luis alfredo ureña quiros

Journal of …, 2003

A monooxygenase encoded by the mtmOIV gene from the mithramycin gene cluster of Streptomyces argillaceus was purified 21-fold by a three-step purification procedure. This monooxygenase catalyzes the oxidative cleavage of the fourth ring of premithramycin B. The enzyme was ...

View PDFchevron_right

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces a rgillaceus through Combinatorial Biosynthesis

Journal of The American Chemical Society, 2003

View PDFchevron_right

Mithramycin Analogues Generated by Combinatorial Biosynthesis Show Improved Bioactivity

Journal of Natural Products, 2008

View PDFchevron_right

Loading...

Loading Preview

Sorry, preview is currently unavailable. You can download the paper by clicking the button above.

Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes NIH Public Access

View PDFchevron_right

Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes

Leandro Garrido

Applied Microbiology and Biotechnology, 2006

View PDFchevron_right

Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents

Chemistry & Biology, 1996

View PDFchevron_right

The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin

Microbial Biotechnology, 2010

View PDFchevron_right

Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

Journal of Bacteriology

View PDFchevron_right

Semi-Synthetic Mithramycin SA Derivatives with Improved AntiCancer Activity

Chemical Biology & Drug Design, 2013

View PDFchevron_right

The aureolic acid family of antitumor compounds

View PDFchevron_right

Cloning and Insertional Inactivation of Streptomyces argillaceus Genes Involved in the Earliest Steps of Biosynthesis of the Sugar Moieties of the Antitumor Polyketide Mithramycin

View PDFchevron_right

Deoxysugar Transfer during Chromomycin A ₃ Biosynthesis in Streptomyces griseus subsp. griseus : New Derivatives with Antitumor Activity

Applied and Environmental Microbiology, 2006

View PDFchevron_right

The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives

Applied Microbiology and Biotechnology, 2006

View PDFchevron_right

Deoxysugar Transfer during Chromomycin A3 Biosynthesis in Streptomyces griseus subsp. griseus: New Derivatives with Antitumor Activity

Applied and Environmental Microbiology, 2006

View PDFchevron_right

Biochemistry Chemistry Organic Chemistry Catalysis Magnetic Resonance Spectroscopy Medicine Streptomyces Mutation Stereochemistry Biosynthesis Multienzyme complexes Glycosyltransferases Amino Acid Sequence Chemistry Biology Oxidation-Reduction Biochemistry and cell biology Carbohydrate Sequence Molecular Sequence Data Glycosyltransferase