Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism (original) (raw)

Protein science : a publication of the Protein Society, 2018

Structural diversity in the AdoMet radical enzyme superfamily

Anna Croft

Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions

Angad Mehta

Journal of Biological Chemistry, 2014

Organometallic Complex Formed by an Unconventional Radical S-Adenosylmethionine Enzyme

Boris Dzikovski

Journal of the American Chemical Society, 2016

Substrate-Dependent Cleavage Site Selection by Unconventional Radical SAM Enzymes in Diphthamide Biosynthesis

Boris Dzikovski

Journal of the American Chemical Society, 2017

Structural Insights into Radical Generation by the Radical SAM Superfamily

Chemical Reviews, 2011

Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

Jorge Spíndola

Nucleic Acids Research, 2001

SPASM and Twitch Domains in S-Adenosylmethionine (SAM) Radical Enzymes

Journal of Biological Chemistry, 2014

Characterization of auxiliary iron-sulfur clusters in a radicalS-adenosylmethionine enzyme PqqE fromMethylobacterium extorquensAM1

Natsaran Saichana

FEBS Open Bio, 2017

Radical Reaction Control in the AdoMet Radical Enzyme CDG Synthase (QueE): Consolidate, Destabilize, Accelerate

Anna Croft

Chemistry - A European Journal, 2016

Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme

F. Berkovitch, J. Jarrett, Yvain Nicolet, Catherine Drennan

Science, 2004

Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

Current Opinion in Structural Biology, 2015

Structure and Catalytic Mechanism of Radical SAM Methylases

Life

Unexpected electron transfer mechanism upon AdoMet cleavage in radical SAM proteins

Proceedings of the National Academy of Sciences, 2009

X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry

Proceedings of the National Academy of Sciences, 2013

The generation of 5′-deoxyadenosyl radicals by adenosylmethionine-dependent radical enzymes

J. Jarrett

Current Opinion in Chemical Biology, 2003

S-Adenosylmethionine radical enzymes

Anjali Patwardhan

Bioorganic Chemistry, 2004

Crystal Structure of the Radical SAM Enzyme Catalyzing Tricyclic Modified Base Formation in tRNA

Miki Senda

Journal of Molecular Biology, 2007

X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification

Proceedings of the National Academy of Sciences, 2013

Radical SAM Enzymes and Metallocofactor Assembly: A Structural Point of View

ACS Bio & Med Chem Au, 2021

Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis

Kenichi Yokoyama

Methods in enzymology, 2018

Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes

Jürgen Moser

The EMBO Journal, 2003

4-Demethylwyosine Synthase from Pyrococcus abyssi Is a Radical-S-adenosyl-l-methionine Enzyme with an Additional [4Fe-4S]+2 Cluster That Interacts with the Pyruvate Co-substrate

Velavan Kathirvelu

Journal of Biological Chemistry, 2012

Biochemical and Kinetic Characterization of Radical S -Adenosyl- l -methionine Enzyme HydG

Christopher Kay

Biochemistry, 2013

Carbon–sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE

Nature Chemistry, 2016

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

Rachel Hutcheson

Journal of the American Chemical Society, 2017

AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation

Nucleic Acids Research, 2004

Radical SAM enzymes in methylation and methylthiolation

Rachel Hutcheson

Radical Breakthroughs in Natural Product and Cofactor Biosynthesis

Kenichi Yokoyama

Biochemistry, 2018

Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase

Angad Mehta

Nature Communications, 2015

Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis

Boris Dzikovski

Science (New York, N.Y.), 2018

Resolving the Multidecade-Long Mystery in MoaA Radical SAM Enzyme Reveals New Opportunities to Tackle Human Health Problems

Kenichi Yokoyama

ACS Bio & Med Chem Au

Radical SAM catalysis via an organometallic intermediate with an Fe-[5'-C]-deoxyadenosyl bond

Rachel Hutcheson

Science, 2016

Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

Jessica Vey

Proceedings of the National Academy of Sciences, 2008

Structural basis for non-radical catalysis by TsrM, a radical SAM methylase

Nature Chemical Biology, 2021