Structural basis for non-radical catalysis by TsrM, a radical SAM methylase (original) (raw)

Life

The methylthiolation reaction mediated by the Radical-SAM enzymes

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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012

Radical SAM enzymes in methylation and methylthiolation

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Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism

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Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions

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Structural Insights into Radical Generation by the Radical SAM Superfamily

Chemical Reviews, 2011

Crystal Structure of the Radical SAM Enzyme Catalyzing Tricyclic Modified Base Formation in tRNA

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Journal of Molecular Biology, 2007

Unanticipated coordination of tris buffer to the Radical SAM cluster of the RimO methylthiotransferase

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Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB

Olga Esakova, Squire Booker

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Structural diversity in the AdoMet radical enzyme superfamily

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Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

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The Radical SAM Superfamily

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Critical Reviews in Biochemistry and Molecular Biology, 2008

Crystal Structure of Tryptophan Lyase (NosL): Evidence for Radical Formation at the Amino Group of Tryptophan

Angewandte Chemie, 2014

Carbon–sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE

Nature Chemistry, 2016

Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase

Angad Mehta

Nature Communications, 2015

Mechanistic Studies of Radical SAM Enzymes: Pyruvate Formate-Lyase Activating Enzyme and Lysine 2,3-Aminomutase Case Studies

Stella Impano

Methods in Enzymology, 2018

L-tyrosine-bound ThiH structure reveals C–C bond break differences within radical SAM aromatic amino acid lyases

Nature Communications

Substrate-Dependent Cleavage Site Selection by Unconventional Radical SAM Enzymes in Diphthamide Biosynthesis

Boris Dzikovski

Journal of the American Chemical Society, 2017

Radical SAM Enzymes and Metallocofactor Assembly: A Structural Point of View

ACS Bio & Med Chem Au, 2021

Biotin synthase: Insights into radical-mediated carbon–sulfur bond formation

Corey Fugate

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012

Thioether bond formation by SPASM domain radical SAM enzymes: C_α H-atom abstraction in subtilosin A biosynthesis

Chemical Communications, 2016

Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes

Jürgen Moser

The EMBO Journal, 2003

Thioether bond formation by SPASM domain radical SAM enzymes: Cα H-atom abstraction in subtilosin A biosynthesis

Chemical Communications, 2016

X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification

Proceedings of the National Academy of Sciences, 2013

SPASM and Twitch Domains in S-Adenosylmethionine (SAM) Radical Enzymes

Journal of Biological Chemistry, 2014

Resolving the Multidecade-Long Mystery in MoaA Radical SAM Enzyme Reveals New Opportunities to Tackle Human Health Problems

Kenichi Yokoyama

ACS Bio & Med Chem Au

S-Adenosylmethionine radical enzymes

Anjali Patwardhan

Bioorganic Chemistry, 2004

ThnL, a B12-dependent radical S-adenosylmethionine enzyme, catalyzes thioether bond formation in carbapenem biosynthesis

Rongfeng Li

2022

RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli

B. Anton, Elisabeth Raleigh

Proceedings of the National Academy of Sciences, 2008

Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme

F. Berkovitch, J. Jarrett, Yvain Nicolet, Catherine Drennan

Science, 2004

Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases

Simon Arragain

Nature Chemical Biology, 2013

Methylations in complex carbapenem biosynthesis are catalyzed by a single cobalamin-dependent radical S-adenosylmethionine enzyme

Rongfeng Li

2019

Anaerobic Sulfatase-maturating Enzymes, First Dual Substrate Radical S-Adenosylmethionine Enzymes

Journal of Biological Chemistry, 2008

Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis

Kenichi Yokoyama

Methods in enzymology, 2018

Mechanistic Investigations of Anaerobic Sulfatase-Maturating Enzyme: Direct C_β H-Atom Abstraction Catalyzed by a Radical AdoMet Enzyme

Journal of the American Chemical Society, 2009