Analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as monoamine oxidase substrates: a second ring is not necessary (original) (raw)
Monoamine oxidase B (MAO-B) is the major catalyst for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation in human brain and other tissues
V. Glover
Neuroscience Letters, 1986
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Biochemical Events in the Development of Parkinsonism Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine
Rona Ramsay
Journal of Neurochemistry, 1987
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Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents
Tomás Herraiz
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012
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Toxication of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and analogs by monoamine oxidase
Mark S Baird
Biochemical Pharmacology, 1990
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Biochemical mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity
James Adams
Biochemical Pharmacology, 1991
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Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1, 2, 5, 6-tetrahydropyridine
Ritik Kumar
Life sciences, 1985
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Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP+), the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Rona Ramsay
Toxicology, 1988
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Effect of serotonergic, corticostriatal and kainic acid lesions on the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine (MPTP) in mice
Anat Tsur
Brain Research, 1986
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Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver
pramod arora
Biochemical and Biophysical Research Communications, 1988
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N-Methyltetrahydro-β-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic β-carbolinium cations by heme peroxidases
Tomás Herraiz
Biochemical and Biophysical Research Communications, 2007
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Pharmacological properties of the MPTP analog trans-1-methyl-4-[4-dimethylaminophenylethenyl]-1,2,3,6-tetrahydropyridine and its pyridinium metabolite in mouse brain synaptosomes: a potential visual marker for substrates of MPTP-induced neurotoxicity
Jeffrey Bloomquist
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2001
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Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: Selective toxicity of 1-methyl-4-(4′-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture
Simon Efange
Experimental Neurology, 1990
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The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety: The parkinsonian toxin MPTP
Muhammad Akram
Journal of Neurochemistry, 2001
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Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease
Francesca Vaglini, Cristina Viaggi
Journal of Neurochemistry, 2004
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Oxidation of Analogs of l-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine by Monoamine Oxidases A and B and the Inhibition of Monoamine Oxidases by the Oxidation Products
Rona Ramsay
Journal of Neurochemistry, 1989
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Strain differences in systematic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in mice correlate best with monoamine oxidase activity at the blood-brain barrier
N. Riachi
Life Sciences, 1988
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The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety
Muhammad Akram Phd
Journal of Neurochemistry, 2001
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Oxidation and enzyme-activated irreversible inhibition of rat liver monoamine oxidase-B by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Keith Tipton
Biochemical Journal, 1986
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Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism
Rona Ramsay
Biochemical and Biophysical Research Communications, 1986
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Prolonged Alterations in Canine Striatal Dopamine Metabolism Following Subtoxic Doses of l-Methyl-4-Phenyl- 1,2,3,6-Tetrahydropyridine (MPTP) and 4'-Amino-MPTP Are Linked to the Persistence of Pyridinium Metabolites
Sanford Markey
Journal of Neurochemistry, 1991
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Dopaminergic Neurotoxicity In Vivo and Inhibition of Mitochondrial Respiration In Vitro by Possible Endogenous Pyridinium-Like Substances
Charles Hoppel
Journal of Neurochemistry, 1991
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Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria
Rona Ramsay
The Journal of Biological Chemistry, 1986
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Chemically induced Parkinson's disease: Intermediates in the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the 1-methyl-4-phenyl-pyridinium ion
T. Truscott
Biochemical and Biophysical Research Communications, 1987
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The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity
Julie Lotharius
The Journal of biological chemistry, 2000
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) effects on enkephalinergic neurons in various regions of mouse brain
Cristina Cosi
Neurochemistry International, 1993
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Obligatory Role for Complex I Inhibition in the Dopaminergic Neurotoxicity of 1Methyl4-phenyl-1,2,3,6-tetrahydropyridine (MPTP
eiko nakamaru-ogiso
Toxicological Sciences, 2006
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In vitro oxidation of MPTP by primate neural tissue: A potential model of MPTP neurotoxicity
Leonid Kelner
Neurochemistry International, 1985
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Metabolite profile resulting from the activation/inactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-methyltetrahydro- β -carboline by oxidative enzymes
Tomás Herraiz
2013
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The inhibition site of MPP+, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase
Rona Ramsay
Archives of Biochemistry and Biophysics, 1987
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The Parkinsonism-inducing Drug 1-Methyl-4-phenylpyridinium Triggers Intracellular Dopamine Oxidation
Julie Lotharius
Journal of Biological Chemistry, 2000
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