Assessment of Severity of Ulcerative Colitis on First Colonoscopic Examination (original) (raw)
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Prevalence of Ulcerative Colitis in Patients Who Underwent Colonoscopy in Benha University Hospitals
Background: Colonoscopy is the most accurate diagnostic tool in IBD. It is useful in detection of the severity and extent of UC. the incidence of IBD especially UC increased significantly among Egyptian patients as evidenced in previous studies in the past ten years. Aim of Study: To study the prevalence of UC among patients referred to the internal medicine endoscopy unit to perform colonoscopy and evaluate the most common presenting symptoms of UC. Patients and Methods: Cross sectional study encompassed 190 patients who underwent colonoscopy during the period from October 2018 to October 2019, the main presenting complaint was recorded and the result of colonoscopy. Results: Prevalence of UC was about 11.05% on the other side, internal hemorrhoids was the commonest diagnosis in group I (Non-UC patients) 26.6% followed by nonspecific colitis in 23.6%. Bleeding per rectum was the main symptom and indication for colonoscopy (50.5%) but was not significantly different among studied groups. Conclusion: Prevalence of UC raised in Egypt in the last years. In this study, it was the 3 rd diagnosis after internal hemorrhoids and non-specific colitis constituting about 11.05%.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
To develop a system to score disease activity based on clinical manifestations in patients with active ulcerative colitis and to assess the relationship of this score with endoscopic disease severity as assessed by colonoscopy. In a pilot study of 43 patients, nine clinical variables were examined by univariate analysis. Six factors that correlated with disease severity included age, well-being, defecation frequency, bloody stool, extraintestinal manifestations (Ext) and hemoglobin (Hb). Multivariate analysis resulted in the generation of a new activity index for the prediction of disease severity. Validation of this index was performed on 88 patients with definite diagnosis of ulcerative coli-tis based on previous histological examination. The activity index is derived as follows: (18 x bloody stool) + (20 x defecation frequency) + (5 x Ext) + (15 x Hb) - (well-being x 17) + (age x 2) + 158. Values below 280, between 280 and 310 and above 310 corresponded to mild, moderate and seve...
The Sigmoidoscopic extent of ulcerative colitis and associated factors in Pakistani population
2021
In this retrospective cohort study, patients who underwent sigmoidoscopy from July 2013 to July 2020 at Liver Clinic, Jail Road, Lahore, were categorized into two cohorts: who had ulcerative colitis confirmed on histology and who had no ulcerative colitis. Extent and severity of the disease as well as coexisting pathologies were also noted. SPSS version 25 was used. Independent sample T-test was applied to compare quantitative variables like age and weight, and chi-square test to compare qualitative variables with two cohorts. The p-value less than 0.05 was opted as significant. Odd ratio with 95% confidence interval (CI) were also computed for each association. Results: About 11.55% patients (165 out of 1428) had ulcerative colitis, whose mean age and mean weight were 38.27 ± 14.15 years and 74.08 ± 13.20 Kg respectively. Among ulcerative colitis patients, 18.2% had proctitis, 22.4% had proctosigmoiditis, 27.7% had left-sided colitis, and 31.5% had extensive colitis. May endoscopic severity score was found 0,1,2, and 3 in 12.1%, 23.6%, 31.5%, and 32.7% patients respectively. Ulcerative colitis cohort had significant association with younger age (p<0.01), female gender (p<0.01), non or former smoking (p=0.02) and presentation with bloody diarrhea (p<0.01), and no association with body weight (p=0.311), presence of diabetes mellitus (p=0.311) and family history of IBD (P=0.368). Conclusion: Endoscopic extent and severity of ulcerative colitis is high in our studied population. Ulcerative colitis is more prevalent in younger age and female gender patients who presented with bloody diarrhea, while the presence of active smoking has negative association with finding the ulcerative colitis. However, presence of family history of IBD, diabetes mellitus and body weight of the patient has no statistical correlation with finding ulcerative colitis during sigmoidoscopic examination in our patients.
TAJ: Journal of Teachers Association
Ulcerative colitis is an idiopathic inflammatory bowel disease characterized by continuous mucosal inflammation that starts in the rectum and extends proximally. Ulcerative colitis is considered frequent in majority of European and North American population and exceptional in most of the developing Asian countries. The present study was designed to estimate the disease severity and colonic involvement of ulcerative colitis in a tertiary care hospital of Rajshahi Medical College. The study population includes of 60 ulcerative colitis patients. Patients were categorized on the basis of disease severity ; moderate : 34, and severe: 26 and involvement of colon: 28 (46.40%) pancolitis, 20 (33.96%) left sided colitis and had 12 (19.61%) proctosigmoiditis.
Journal of Crohn's & colitis, 2015
Current endoscopic activity scores for ulcerative colitis (UC) do not take into account the extent of mucosal inflammation. We have developed a simple endoscopic index for UC that takes into account the severity and the distribution of mucosal inflammation. In this multicenter trial, UC patients undergoing colonoscopy were prospectively enrolled. For the Modified Score (MS), the sum of the Mayo endoscopic subscore (MES) for five colon segments (ascending, transverse, descending, sigmoid and rectum) was calculated. The Extended Modified Score (EMS) was obtained by multiplying the MS by the maximal extent of inflammation. The Modified Mayo Endoscopic Score (MMES) was obtained by dividing the EMS with the number of segments with active inflammation. Colon biopsies were standardly obtained from rectum and sigmoid, as well as from all inflamed segments. Clinical activity was scored according to the Partial Mayo score (PMS). Biological activity was scored according to C-reactive protein (...
International Journal of Research in Medical Sciences, 2014
Ulcerative colitis is a recurrent chronic inflammatory disease of the intestines with unknown etiology and is associated with Crohn's disease which is categorized in IBD class. This disease is caused by abnormal local immune system response to intestinal flora or may be to some self-antigens in genetically susceptible individuals. Ulcerative colitis is a non-granulomatous disease limited to the colon and with exception in severe cases is limited to the mucosa and submucosa. 1 It is estimated that the number of people with this disease in Iran is near to 10000 people. The incidence of the disease has increased in recent decades. The incidence of Crohn's disease and ulcerative colitis in different geographic regions vary from 0.1 to 11 and 0.5 to 24.5 per 1000 person, respectively. 2 The disease is more common in whites in the United States and there was no sexual preference. The incidence of Colitis in North America is 10-12 per 100000 people, with a peak age incidence of 15-25 years old. 3 The incidence of ulcerative colitis is one in a thousand. The overall shape of the data distribution of ulcerative colitis is as a bi-wavelike in which a second peak occurs in the sixth decade of human life and affects women more than men. Geographical distribution of colitis and colonic diseases in the world is the same with high incidence in United States, Canada, United Kingdom and Scandinavia. High incidence has been seen in northern Europe and America than in southern. 4 The most incidence rate of inflammatory bowel disease is ABSTRACT Background: Ulcerative colitis is one of the inflammatory bowel diseases with unknown etiology. Genetic and environmental factors are thought to be effective in this disease. The aim of this study is to assessment of demographic features and clinical symptoms of ulcerative colitis patients refereed to Emam hospital in Ardabil city. Methods: In this retrospective cross-sectional study, 80 cases of ulcerative colitis referred to Emam hospital in Ardabil city were evaluated during 2004-2011. The diagnosis was confirmed based on clinical features, colonoscopy, and pathology and resulting of other causes. Data were collected through direct interview and analyzed by statistical method in SPSS software. Results: Mean age of patients was 36.4 (SD=18.4). Duration of symptoms onset until diagnosis was 8 months. Male to female ratio was 0.8/1. 38(47.5%) of patients were male and 42 (52.5%) were female. 3 (3.75%) of patients have history of positive UC and 4 (5%) history of appendectomy. According to colonoscopy finding, 1 (1.25%) have rectum involvement, 27 (33.75%) recto sigmoid, 23 (28.75%) left side colon and 4 (5%) have pan colitis. Conclusion: Results showed that in compare with other places, clinical signs of ulcerative colitis in Ardabil province are different and so doing other d epidemiologic studies based on population to determine incidence and prevalence ulcerative colitis in Ardabil province is necessary.
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 2016
Background: The prevalence ulcerative colitis (UC) in RSCM Jakarta in 1991-1995 is 2.5%. The disease affects men and women at similar rates or slightly more common in women than in men. Age of onset follows a bimodal pattern, with a peak at 15-25 years and a smaller one at 55-65 years, although the disease can occur in people of any age. The precise etiology of UC is not well understood. UC is precipitated by a complex in Dr. Saiful Anwar General Hospital Malang. Method: This is a retrospective survey analysis from medical record which was taken from 2170 patients who underwent colonoscopy in Dr. Saiful Anwar General Hospital Malang from January 2010 to December 2014. Demographic setting (sex, age), clinical features, lifestyle, diagnosis based on colonoscopy were analyzed as the variables. Results: Total patients with UC was 176 patients. The prevalence of UC during 2010-2014 was 8.2% at Dr. Saiful Anwar General Hospital. There was a similar prevalence of sex between male and female patients, in which 95 (53.4%) were male and 81 (46.6%) were female. The average age of patients with UC was 41,6 years. Most patients were presented with abdominal pain (32.90%) and weight loss (42.1%). The diagnosis based on colonoscopy were pancolitis (36%), proctosigmoiditis/proctitis (31.81%), and left-sided colitis (21.9%). The risk Majority of ulcerative colitis study samples were non-smoker (75%), not consuming herbal treatment/NSAID diet and UC (r =-0.106, p = 0.000). Conclusion: average age was 41.6 years. Patients presented with various clinical symptoms, most are abdominal pain and
BMC gastroenterology, 2018
Colonoscopy plays crucial role in the establishment of the diagnosis, management and follow-up of ulcerative colitis (UC). None of the currently widely used endoscopic scores consider disease extent, and therefore do not correlate with the real severity of UC. Our aim was to assess the accuracy of a new score, the Pancolonic Modified Mayo Score that can reflect not only the severity, but the extent of active UC. One hundred and four UC patients were enrolled in this prospective study. The Endoscopic Mayo Scores of the involved area of the five colorectal segments were added; furthermore, the sum was multiplied by 3 in case of eMayo ≥2 (range 0 [normal] to 45 [most severe]) to obtain the Pancolonic Modified Mayo Score (panMayo) in order to clearly distinguish the active and inactive disease. We analysed the correlation of panMayo Score with eMayo and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) and complicated disease outcome. We compared the endoscopic indices with serum ...
Ulcerative Colitis: Experience at a Tertiary Care Center
Rawal Medical Journal, 2005
Objective: Ulcerative colitis has a worldwide distribution but its prevalence and clinical patterns in Pakistan are not known. This study was performed to ascertain the clinical patterns of ulcerative colitis in patients referred to a tertiary care center. Methods: All patients presenting with diarrhea, blood in stools and biopsy proven for ulcerative colitis were prospectively followed for clinical features, laboratory findings, endoscopic features and treatment response over the study period. Results: A total of 85 patients were seen and followed for up to 8 years. All had diarrhea with blood in stools. All had numerous white blood cells in stool. Erythrocyte sedimentation rate was elevated in 94 % of patients. More than half had mild disease and distal colitis. All patients responded well to standard treatment with anti-inflammatory drugs. 2 Conclusion: Most patients of ulcerative colitis were mild in severity and had distal involvement. Clinical features in this cohort were similar to patients in most other parts of world. All responded to standard treatment.