Efficacy of the association of formulation with Coffea canephora extract and phonophoresis against gynoid lipodystrophy in women population: development, characterization and clinical study (original) (raw)
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Pharmaceuticals
Recently, the herbal compress was successfully developed and applied for cellulite treatment. The aim of this study was to formulate a more convenient dosage form of herbal application from the original formula. In addition, we aimed to characterize and evaluate the stability of the developed dosage form. A gelled emulsion, or an “emgel,” incorporated with 0.1 wt% tea and coffee extracts (1:1 ratio) plus 5 wt% essential oils (mixed oil) was prepared. The caffeine content in the finished product obtained from tea and coffee extracts analyzed by HPLC was 48.1 ± 2.3 µg/g. The bio-active marker monoterpenes of mixed oil characterized by headspace GCMS were camphene 50.8 ± 1.8 µg/mg, camphor 251.0 ± 3.2 µg/mg, 3-carene 46.7 ± 1.8 µg/mg, α-citral 75.0 ± 2.1 µg/mg, β-citral 65.6 ± 1.3 µg/mg, limonene 36.8 ± 6.7 µg/mg, myrcene 53.3 ± 4.5 µg/mg, α-pinene 85.2 ± 0.6 µg/mg, β-pinene 88.4 ± 1.1 µg/mg, and terpinene-4-ol 104.3 ± 2.6 µg/mg. The stability study was carried out over a period of 3 m...
Botanical Extracts Used in the Treatment of Cellulite
Dermatologic Surgery, 2006
BACKGROUND. Cellulite is defined as skin relief alterations that give the skin an orange peel or mattress appearance. The lesions tend to be asymptomatic and may be considered the anatomic expressions of the structures in the affected area, such as the fat and subcutaneous septa. OBJECTIVE. The present article reviews the most important botanical extracts used as active ingredients in the treatment of cellulite, as well as the steps to obtain these botanicals as raw material and their standardization and quality control, which are important to guarantee their therapeutic action. METHODS. The current literature was reviewed, and we also obtained information from the manufacturers of the prducts that contained botanicals because of the few publications about this subject. CONCLUSIONS. The reduction in fat deposits through the continuous use of anticellulite products depends on the availability of the active ingredient at the action site, the concentration of the ingredient in the formulation, and the physiochemical characteristics particular to each active ingredient. The botanicals used in topical products must have standardized extracts, which would permit each phytomedicine to have the same effect anywhere in the world. New scientific research is necessary to verify the efficacy and ideal concentrations of such substances.
Efficacy of an Anti-Cellulite Herbal Emgel: A Randomized Clinical Trial
Pharmaceuticals, 2021
Cellulite describes unsightly skin overlying subcutaneous fat around thighs and buttocks of post-pubescent females. A herbal ‘emgel’ containing volatile oils and extracts of A traditional Thai herbal compress was tested in a double-blind, placebo-controlled trial with 18 women aged 20–50 year with severe cellulite. Appearance of cellulite (primary outcome), thigh circumferences, skin firmness, and cutaneous blood flow (secondary outcomes) were assessed at baseline, 2, 4, 8 and 12 weeks with a 2-week follow-up. Herbal emgel applied onto the thigh skin twice daily reduced cellulite severity scores in every time point. The score was reduced from 13.4 ± 0.3 (baseline) to 12.1 ± 0.3 (week 2) and 9.9 ± 0.6 (week 12). All secondary outcomes improved with both placebo and herbal emgels suggesting that ingredients in the base-formulation might be responsible. Querying of participants, analysis of their diaries, and physical monthly inspections found no adverse events. The herbal emgel safely...
Vaginal atrophy is one of the bothering problems of postmenopausal women. Phytoestrogens are one of the alternative treatments for vaginal atrophy. The aim of this study was to evaluate the physicochemical properties and stability of vaginal cream containing Glycine max, Trigonella Foenum, Glycyrriza glabra and Aloe barbadensis extracts. To choose the best formulation a general formula of oil in water emulsion was considered and then corrected. The pH of formulations was in the normal range of vaginal pH and it can be an effective parameter in normalizing increased vaginal pH in vaginal atrophy. Microbial challenge test showed formulation preservative had the effective ability to preserve the formula. Release study carried out according to the permeated amount total flavonoids. Determination of total flavonoids was carried out using Aluminum chloride colorimetric method. The best formulation was chosen with respect to desirable appearance, consistency, viscosity, and stability param...
Journal of Cosmetic Dermatology, 2012
Background The pathophysiology of cellulite involves changes in the subcutaneous adipose layer and the extracellular matrix (ECM) that supports it together with overlying dermal layer. Cellular mechanisms governing cellulite are not fully understood. However, it is accepted that changes include enhanced lipogenesis, decreased lipolysis, and increased lipid storage within the adipocytes as well as changes in the dermal architecture. Aim In our studies the ability of cosmetic agents Furcellaria lumbricalis, Fucus vesiculosus, retinoid, conjugated linoleic acid (CLA), and a glaucine mixture to stimulate in vitro 1) lipolysis in human adipocytes and 2) production of pro-collagen I by fibroblasts was investigated in vitro. The ability of these ingredients to improve cellulite condition in vivo was also determined. Patients ⁄ Methods Mature adipocytes and 'aged' fibroblasts were used for in vitro studies. The assessment of cellulite in vivo was performed by dermatological grading and ultrasound measurements. Results Mature adipocytes treated with combined actives resulted in a significant synergistic increase in free glycerol release. On ''aged'' fibroblasts, combined treatment of F. vesiculosus and F. lumbricalis stimulated pro-collagen I production. CLA increased procollagen I production, but the glaucine mixture had no effect. The clinical study demonstrated a significant improvement in cellulite grading by a dermatologist after 8 and 12 weeks vs. vehicle, and ultrasound imaging showed a significant decrease in fat thickness compared with placebo after 12 weeks. Conclusions Our studies revealed a potent cocktail of ingredients that when combined together can act in vitro to markedly improve lipolysis mechanisms and by way of stimulating pro-collagen I can also have an effect on the surrounding extracellular matrix. The in vitro actions of the ingredients were translated in vivo, where a clinical improvement of cellulite condition was observed.
Development and Characterization of Topical Liposomal Gel Formulation for Anti-Cellulite Activity
2013
Objective: The present study was aimed at development and characterization of a novel liposomal gel formulation of caffeine that could reduce the cellulite depositions over human body. It is already reported that liposomes made up of phosphatidylcholine may reduce cellulites from fat deposition sites by emulsifying and breaking down the fat and cholesterol while caffeine facilitate the movement and removal of dissolved cellulite in blood circulation. Experimental work done: For this study liposomes of phosphatidylcholine and cholesterol were prepared by thin film hydration technique. The prepared liposomes were characterized for vesicle size, shape, morphology, zeta potential, encapsulation efficiency, in vitro drug release and drug disposition in animal model. Results and Discussion: The percentages of caffeine entrapped in all liposome formulations varied between 37 and 58%. Gel containing liposomal dispersion was prepared in carbopol 934 and characterized for gel strength, viscos...
Nanoemulsion containing caffeine for cellulite treatment: characterization and in vitro evaluation
Brazilian Journal of Pharmaceutical Sciences
The Ginoide Hydrolipodystrophy (GHLD), commonly known as cellulite, occurs in 80-90% of the female population after the puberty period and comes from a metabolic modification in the cutaneous adipose tissue. Caffeine has been used in topical formulations due to its lipolytic action. We studied a nanoemulsion (F3) containing caffeine with two surfactants (oleth-3 and oleth-20) by emulsification method by phase inversion temperature inversion (PIT). The polydispersion indices (PDI) showed the reduced deviation of 0.1. The mean droplet size was ~ 40 nm. The evaluated constant of Ostwald, in the refrigerator condition was the most favorable during the stability test. In the In Raman spectroscopy assay, the caffeine bands found in F3 were compatible with those found in the caffeine solution (1337, 652.5 and 558.2 cm-1). There was no interaction of caffeine anhydrous with other ingredients in nanoemulsion. In the in vitro safety assay the result of 1.4 ranked the F3 as slightly irritating. In the natural membrane, cutaneous permeation test (human skin) permeate concentrations did not exceed the saturation concentration of the PBS buffer (48.96 μg/3 mL). The caffeine solution and F3 permeated statistically equal, but the nanoemulsion visually and sensorially improved the caffeine precipitation.
An accumulation of fat in the subcutaneous tissue causes cellulite and dimpling on the surface of the skin. Although not related to obesity, obesity worsens cellulite. There are abundant topical anticellulite creams on the market, but the efficacy of these creams has not been scientifically proven. A combination of Centella asiatica L. leaves extract and green coffee (Coffea canephora robusta P.) bean extract in a cream preparation was clinically tested in 30 women for 84 days in the absence of diet and exercise. The descriptive-true experimental before (T-0)-after (T-84) method was used to classify the cellulite (grade 1-3) and to determine the slimming effect. The cellulite appearance and the body circumferences (abdominal and thigh) perimeters were photographed 5cm and 10cm below the navel and below the gluteal fold. The results of before and after the treatment showed that grade 1 cellulite lower (p < 0.000), the measurement of abdominal circumference showed reduction (p < 0.013), but the measurement of both thigh circumference showed insignificantly reduction (p < 0.512). The combination of both extracts reduce cellulite and fat deposits in the abdominal area, making the volunteers look slimmer.
Application of phytocosmetic formulations based on Coffea arabica leaves extract
2020
Introduction: Coffee (Coffea arabica L.) leaf is well known for its cosmetic uses and skin benefits, for example its ability to help maintain natural skin’s humidity. The aim of this study was to design and evaluate the cosmetic effectiveness of the formulation of creams containing different concentrations of C. arabica leaves ethanol extract using hydrating, emollient raw materials and other excipients. Extracts from C. arabica seeds and Calahuala (Phlebodium decumanum (Willd.) J. Sm.) rhizome have demonstrated sun protection effect, so they are included in the formulation.Methods: Several formulations were made in which the raw materials and the concentration of the extracts varied from 1 to 5%, and thus, achieve a formulation to evaluate its effectiveness in tests such as pH skin compatibility, sun protection factor, among others. For optimal sun protection effects, extracts from C. arabica leaves and P. decumanum rhizome were added.Results: Results revealed that Formulation 2B, ...