Chemotherapeutic potential of 9-phenyl acridine: biophysical studies on its binding to DNA (original) (raw)
Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides
Laurence Wakelin
Molecular pharmacology, 2000
View PDFchevron_right
Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds
Jana Janockova, Peter Fedoročko, Slavka Hamulakova
European Journal of Pharmaceutical Sciences, 2015
View PDFchevron_right
Interactions of Acridine Antitumor Agents with DNA: Binding Energies and Groove Preferences
David Graves
Biochemistry, 1995
View PDFchevron_right
Major Groove Binding and ‘DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N -(2-(Dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA: X-ray Structure Complexed to d(CG(5-BrU)ACG) 2 at 1.3-Å Resolution
Alan Todd
Journal of Medicinal Chemistry, 1999
View PDFchevron_right
Crystal Structure of the Topoisomerase II Poison 9-Amino-[ N -(2-dimethylamino)ethyl]acridine-4-carboxamide Bound to the DNA Hexanucleotide d(CGTACG) 2 †
Laurence Wakelin
Biochemistry, 1999
View PDFchevron_right
Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity
Maria Kozurkova
Bioorganic Chemistry, 2019
View PDFchevron_right
Cell line selectivity and DNA breakage properties of the antitumour agent N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide: role of DNA topoisomerase II
Erasmus Schneider
European Journal of Cancer and Clinical Oncology, 1988
View PDFchevron_right
Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues
Swarna Gamage
Cancer research, 2001
View PDFchevron_right
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents
Gordon Rewcastle
Journal of medicinal …, 1987
View PDFchevron_right
Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons
Laurence Wakelin
Nucleic Acids Research, 2002
View PDFchevron_right
Novel 3,9-Disubstituted Acridines with Strong Inhibition Activity against Topoisomerase I: Synthesis, Biological Evaluation and Molecular Docking Study
Maria Kozurkova
Molecules
View PDFchevron_right
Model study on the sequence specific stacking by chromophore of an anticancer drug, acridine carboxamide with base pairs of DNA
Raghab Parajuli
2007
View PDFchevron_right
Novel imidazolyl derivatives of 1,8-acridinedione as potential DNA-intercalating agents
Bahram Hemmateenejad
Journal of the Iranian Chemical Society, 2011
View PDFchevron_right
Modeling and Biological Investigations of an Unusual Behavior of Novel Synthesized Acridine-Based Polyamine Ligands in the Binding of Double Helix and G-Quadruplex DNA
Andrea Bencini
ChemMedChem, 2010
View PDFchevron_right
Total QSAR study on Phenyl Acridine Derivatives in Reference to DNA Binding Affinity
Mamta Thakur
2013
View PDFchevron_right
Antitumor Polycyclic Acridines. 7. 1 Synthesis and Biological Properties of DNA Affinic Tetra-and Pentacyclic Acridines
Johnson Stanslas
Journal of medicinal …, 2000
View PDFchevron_right
Steric Influence on Anti-Cancer Activity of Phenyl Acridine Derivatives
brij tiwari
Novel Approaches in Cancer Study, 2020
View PDFchevron_right
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex
C. Freudenreich
Proceedings of the National Academy of Sciences, 1994
View PDFchevron_right
Cytotoxic 3,6-bis((imidazolidinone)imino)acridines: Synthesis, DNA binding and molecular modeling
Maria Kozurkova
Bioorganic & Medicinal Chemistry, 2011
View PDFchevron_right
DNA Binding by Fagaronine and Ethoxidine, Inhibitors of Human DNA Topoisomerases I and II, Probed by SERS and Flow Linear Dichroism Spectroscopy †
Igor Nabiev
The Journal of Physical Chemistry B, 1999
View PDFchevron_right
Interaction of an Acridine Dimer with DNA Quadruplex Structures
Jean Vigneron
Journal of Biomolecular Structure and Dynamics, 2001
View PDFchevron_right
Nucleic acid binding drugs—XIV
B. Baguley
Biochemical Pharmacology, 1986
View PDFchevron_right
Drug-DNA Interaction Studies of Acridone-Based Derivatives
Elvis Martis, Apoorva Ugarkar
Nucleosides, nucleotides & nucleic acids, 2015
View PDFchevron_right
Study by optical spectroscopy and molecular dynamics of the interaction of acridine–spermine conjugate with DNA
jean-guy Delcros
Biophysical Chemistry, 2008
View PDFchevron_right