Dr Tabarak Malik | Jimma University, Ethiopia (original) (raw)
Dr. Tabarak Malik earned his doctoral degree from the CSIR-Indian Institute of Toxicology Research, Lucknow. He holds a postgraduate degree in Biochemistry and Molecular Biology from Dr. Ram Manohar Lohia Avadh University Ayodhya.
With over 20 years of teaching and research experience, he has contributed to graduate and postgraduate education in India and abroad. Dr. Malik has been instructing courses such as Medical Biochemistry, Genetics, Genetic Engineering, Cell & Molecular Biology, Enzymology & Clinical Chemistry, Immunology, Biotechnology, and Toxicology at both undergraduate and postgraduate levels.
He boasts authorship and co-authorship of more than 91 international research publications in peer-reviewed journals. Additionally, he has authored over 13 book chapters in edited volumes and published three books with renowned international publishers. Publications from reputed houses like Springer-Nature, BMC, John Wiley, Elsevier, Taylor and Francis, PLOS ONE, Dove, Royal Society UK, Frontiers and American Chemical Society (ACS) etc. are a regular occurrence.
Dr. Malik holds the position of Review Editor at Frontiers in Toxicology and serves as an Associate Editor for Frontiers in Reproductive & Developmental Toxicology.
His research interests span a broad spectrum of areas, including Medicine, Pharmacology, Toxicology, and Pharmaceutics, Biomedical Sciences, Multidisciplinary studies, Biochemistry, Genetics, and Molecular Biology, Immunology and Microbiology, and Environmental Toxicology.
This reflects his commitment to a multidisciplinary approach to advancing knowledge in various scientific domains.
Phone: +251960263441
Address: Department of Biomedical Science
Institute of Health
Jimma University
Ethiopia
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Papers by Dr Tabarak Malik
Environmental Science: Nano
Nanofertilizer prepared with urea-hydroxyapatite amalgamation along with PGPR promotes urea avail... more Nanofertilizer prepared with urea-hydroxyapatite amalgamation along with PGPR promotes urea availability over longer period of plant growth and reduces wasteful urea expense in soil, curtailing environmental pollution.
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International Journal of Agronomy
The study aimed to compare the tolerance capacity of Cyperus iria, Achyranthes aspera, and Eruca ... more The study aimed to compare the tolerance capacity of Cyperus iria, Achyranthes aspera, and Eruca sativa to lead-contaminated and chromium-contaminated soils and to check their phytoremediation potential by pot culture experimentation. The experiment was conducted in three replicates in pots having 4 kg of sieved soil mixed with different doses of chromium, 0, 50, 100, 150, 200, 250, 300, and 350 mg·kg−1, and lead, 0, 100, 200, 300, 400, 500, 600, 700, and 800 mg·kg−1. The experiment was conducted for 80 days, and roots were harvested two times, i.e., at 40 days and 80 days after sowing. Metal accumulation in the roots was determined by the atomic absorption spectrophotometry method. The result of the study indicated that C. iria has the maximum potential to accumulate both the metals in its roots than other two plants. The order of chromium metal accumulation was found to be C. iria > E. sativa > A. aspera. On the other hand, the order of lead metal accumulation was found to b...
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Open Biology
Papaver somniferum L. (Family: Papaveraceae) is a species well known for its diverse alkaloids (1... more Papaver somniferum L. (Family: Papaveraceae) is a species well known for its diverse alkaloids (100 different benzylisoquinoline alkaloids (BIAs)). L-tyrosine serves as a precursor of several specific metabolites like BIAs. It has been used as an antitussive and potent analgesic to alleviate mild to extreme pain since ancient times. The extraction of pharmaceutically important alkaloids like morphine and codeine from poppy plant reflects the need for the most suitable and standard methods. Several analytical and extraction techniques have been reported in open literature for morphine, codeine and other important alkaloids which play a vital function in drug development and drug discovery. Many studies suggest that opioids are also responsible for adverse effects or secondary complications like dependence and withdrawal. In recent years, opium consumption and addiction are the most important risk factors. Many evidence-based reviews suggest that opium consumption is directly linked o...
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Elsevier eBooks, 2023
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International Journal of Surgery
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PLOS ONE
This study aimed to assess heavy metals in the surface sediments of the Bharalu river, India. Met... more This study aimed to assess heavy metals in the surface sediments of the Bharalu river, India. Metal concentrations ranged from 6.65−54.6 mg/kg for Ni, 25.2−250.0 mg/kg for Zn, 83.3−139.1 mg/kg for Pb, and 11940.0−31250.0 mg/kg for Fe. The level of metal contamination was assessed using sediment quality guidelines, geo-accumulation index (Igeo), enrichment factor (EF), pollution Load Index (PLI),Nemerow’s pollution index (PIN), and potential ecological risk index. Pb exceeded the sediment quality guidelines at all sites indicating a potential threat to the river ecosystem. (Igeo) and EF also showed moderate to severe enrichment for Pb. Potential ecological risk (RI) showed low risk in the sediments, and Pb is the major contributor to ecological risk. Overall, pollution indices revealed comparably higher contamination of the sediments in the downstream sites than in the upstream site. PCA and correlation matrix analysis indicated both anthropogenic and natural origins for metals. Amon...
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Medicinal Plants of the Asteraceae Family, 2022
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BioMed Research International
Cosmetics and personal care items are used worldwide and administered straight to the skin. The h... more Cosmetics and personal care items are used worldwide and administered straight to the skin. The hazardous nature of the chemical surfactant utilized in the production of cosmetics has caused alarm on a global scale. Therefore, bacterial biosurfactants (BS) are becoming increasingly popular in industrial product production as a biocompatible, low-toxic alternative surfactant. Chemical surfactants can induce allergic responses and skin irritations; thus, they should be replaced with less harmful substances for skin health. The cosmetic industry seeks novel biological alternatives to replace chemical compounds and improve product qualities. Most of these chemicals have a biological origin and can be obtained from plant, bacterial, fungal, and algal sources. Various biological molecules have intriguing capabilities, such as biosurfactants, vitamins, antioxidants, pigments, enzymes, and peptides. These are safe, biodegradable, and environmentally friendly than chemical options. Plant-bas...
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IET Nanobiotechnology
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Objectives: Depo-Provera is a widely known brand name for medroxyprogesterone acetate. It has som... more Objectives: Depo-Provera is a widely known brand name for medroxyprogesterone acetate. It has some adverse effects which is reversible after discontinuation include changes in bleeding patterns and bone mineral density loss risk of weight gain in obese adolescents. The study aims to investigate the effects of Depo-Provera on body weight and blood pressure of Ethiopian women. Institutional based cross-sectional study design was conducted. The data was analyzed using SPSS version 21 software packages. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. The p-values less than 0.05 were considered as statistically significant. Results The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p-value-0.02 and p-value-0.019 respectively). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera...
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Background Noncommunicable diseases, such as cardiovascular diseases, continue to be the leading ... more Background Noncommunicable diseases, such as cardiovascular diseases, continue to be the leading cause of morbidity and mortality around the world. Hypertension and dyslipidemia appear to be the two most important modifiable risk factors contributing to the global rise in cardiovascular disease. Several plant preparations are currently being touted as having benefits for such cardiovascular risk factors. African moringa, Moringa stenopetala, is one of these plants used in Ethiopia. Therefore, this study aimed to assess and compare the serum lipid profiles and blood pressure measurements of Moringa stenopetala herbal tea drinkers and non-drinker hypertensive patients attending chronic care follow-up at Bale zone hospitals. Methods A comparative cross-sectional study, involving 128 blood samples (64 each of Moringa stenopetala herbal tea drinkers and nondrinkers), was conducted on hypertensive patients who were on chronic care follow-up from July 1 to August 30, 2021. A face-to-face i...
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PLOS ONE, Aug 8, 2022
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SAGE Open Medicine
Objectives: The purpose of conducting this study was to assess fatty liver disease and its correl... more Objectives: The purpose of conducting this study was to assess fatty liver disease and its correlation with glycemic control in type 2 diabetes mellitus patients. In addition, evaluation of associated factors and correlation analysis between the fatty liver index and hemoglobin A1C level in patients with type 2 diabetes mellitus was another aim of this study. Methods: A hospital-based cross-sectional study was conducted among type 2 diabetes mellitus patients attending at diabetes clinic of Dessie Comprehensive Specialized Hospital located in south Wollo, Ethiopia. It was conducted from July to August 2021. The fatty liver index was calculated to assess fatty liver disease. Simple descriptive statistics, multivariate analysis, and an independent sample t-test were utilized for statistical analysis. Multiple logistic regression analysis was used to determine the associated factors of fatty liver. The p value < 0.05 was considered as statistically significant. Results: In this stud...
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Medicinal Plants of the Asteraceae Family, 2022
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Additional file 1.
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Swertia (Gentianaceae), a diverse genus, is mentioned as a potential herbal drug in Ayurvedic, Un... more Swertia (Gentianaceae), a diverse genus, is mentioned as a potential herbal drug in Ayurvedic, Unani, and Siddha traditional systems of medicine. Since time immemorial, 70 Swertia species have been used worldwide to cure several health illnesses associated with malaria, cancer, diabetes, inflammation, liver complications, different kinds of fever, etc. Swertia herb is used as the principal component in several marketed herbal/polyherbal formulations. Medicinal usage of Swertia is endorsed to the miscellaneous compounds, viz. xanthones, iridoids, seco-iridoids, and triterpenoids. Swertia is one of the most imperative trade herbs since its market value rises by 10% yearly. A chain of systematic isolation of bioactive compounds and their diverse range of pharmacological effects during the last 10–15 years proved this genus as an industrially important plant. This chapter makes an effort to present the comprehensive assessment on distribution, ethnopharmacology, biological activities, p...
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Biotechnology for Biofuels and Bioproducts
Bioethanol is recognized as a valuable substitute for renewable energy sources to meet the fuel a... more Bioethanol is recognized as a valuable substitute for renewable energy sources to meet the fuel and energy demand of the nation, considered an environmentally friendly resource obtained from agricultural residues such as sugarcane bagasse, rice straw, husk, wheat straw and corn stover. The energy demand is sustained using lignocellulosic biomass to produce bioethanol. Lignocellulosic biomass (LCBs) is the point of attention in replacing the dependence on fossil fuels. The recalcitrant structure of the lignocellulosic biomass is disrupted using effective pretreatment techniques that separate complex interlinked structures among cellulose, hemicellulose, and lignin. Pretreatment of biomass involves various physical, chemical, biological, and physiochemical protocols which are of importance, dependent upon their individual or combined dissolution effect. Physical pretreatment involves a reduction in the size of the biomass using mechanical, extrusion, irradiation, and sonification meth...
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Frontiers in Endocrinology
Alarin is a member of the galanin family of neuropeptides that is widely expressed in the central... more Alarin is a member of the galanin family of neuropeptides that is widely expressed in the central nervous system and peripheral tissues in humans and rodents. It was initially isolated fifteen years ago in ganglionic cells of human neuroblastoma. Subsequently, it was demonstrated to be broadly distributed in the blood vessels, skin, eyes, peripheral and central nervous systems, thymus, gastrointestinal tract, and endocrine organs of different species. Alarin is a 25 amino acid neuropeptide derived from the alternative splicing of the GALP gene, missing exon 3. It is found to be involved in several physiological functions that include feeding behavior, energy homeostasis, glucose homeostasis, body temperature, and reproduction. It has also vasoactive, anti-inflammatory, anti-edema, and antimicrobial activities. However, the physiological effects of alarin have not been fully elucidated and the receptors that mediate these effects are not currently known. Unearthing the novel biologic...
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South African Journal of Botany
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Environmental Science: Nano
Nanofertilizer prepared with urea-hydroxyapatite amalgamation along with PGPR promotes urea avail... more Nanofertilizer prepared with urea-hydroxyapatite amalgamation along with PGPR promotes urea availability over longer period of plant growth and reduces wasteful urea expense in soil, curtailing environmental pollution.
Bookmarks Related papers MentionsView impact
International Journal of Agronomy
The study aimed to compare the tolerance capacity of Cyperus iria, Achyranthes aspera, and Eruca ... more The study aimed to compare the tolerance capacity of Cyperus iria, Achyranthes aspera, and Eruca sativa to lead-contaminated and chromium-contaminated soils and to check their phytoremediation potential by pot culture experimentation. The experiment was conducted in three replicates in pots having 4 kg of sieved soil mixed with different doses of chromium, 0, 50, 100, 150, 200, 250, 300, and 350 mg·kg−1, and lead, 0, 100, 200, 300, 400, 500, 600, 700, and 800 mg·kg−1. The experiment was conducted for 80 days, and roots were harvested two times, i.e., at 40 days and 80 days after sowing. Metal accumulation in the roots was determined by the atomic absorption spectrophotometry method. The result of the study indicated that C. iria has the maximum potential to accumulate both the metals in its roots than other two plants. The order of chromium metal accumulation was found to be C. iria > E. sativa > A. aspera. On the other hand, the order of lead metal accumulation was found to b...
Bookmarks Related papers MentionsView impact
Open Biology
Papaver somniferum L. (Family: Papaveraceae) is a species well known for its diverse alkaloids (1... more Papaver somniferum L. (Family: Papaveraceae) is a species well known for its diverse alkaloids (100 different benzylisoquinoline alkaloids (BIAs)). L-tyrosine serves as a precursor of several specific metabolites like BIAs. It has been used as an antitussive and potent analgesic to alleviate mild to extreme pain since ancient times. The extraction of pharmaceutically important alkaloids like morphine and codeine from poppy plant reflects the need for the most suitable and standard methods. Several analytical and extraction techniques have been reported in open literature for morphine, codeine and other important alkaloids which play a vital function in drug development and drug discovery. Many studies suggest that opioids are also responsible for adverse effects or secondary complications like dependence and withdrawal. In recent years, opium consumption and addiction are the most important risk factors. Many evidence-based reviews suggest that opium consumption is directly linked o...
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Elsevier eBooks, 2023
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International Journal of Surgery
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PLOS ONE
This study aimed to assess heavy metals in the surface sediments of the Bharalu river, India. Met... more This study aimed to assess heavy metals in the surface sediments of the Bharalu river, India. Metal concentrations ranged from 6.65−54.6 mg/kg for Ni, 25.2−250.0 mg/kg for Zn, 83.3−139.1 mg/kg for Pb, and 11940.0−31250.0 mg/kg for Fe. The level of metal contamination was assessed using sediment quality guidelines, geo-accumulation index (Igeo), enrichment factor (EF), pollution Load Index (PLI),Nemerow’s pollution index (PIN), and potential ecological risk index. Pb exceeded the sediment quality guidelines at all sites indicating a potential threat to the river ecosystem. (Igeo) and EF also showed moderate to severe enrichment for Pb. Potential ecological risk (RI) showed low risk in the sediments, and Pb is the major contributor to ecological risk. Overall, pollution indices revealed comparably higher contamination of the sediments in the downstream sites than in the upstream site. PCA and correlation matrix analysis indicated both anthropogenic and natural origins for metals. Amon...
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Medicinal Plants of the Asteraceae Family, 2022
Bookmarks Related papers MentionsView impact
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BioMed Research International
Cosmetics and personal care items are used worldwide and administered straight to the skin. The h... more Cosmetics and personal care items are used worldwide and administered straight to the skin. The hazardous nature of the chemical surfactant utilized in the production of cosmetics has caused alarm on a global scale. Therefore, bacterial biosurfactants (BS) are becoming increasingly popular in industrial product production as a biocompatible, low-toxic alternative surfactant. Chemical surfactants can induce allergic responses and skin irritations; thus, they should be replaced with less harmful substances for skin health. The cosmetic industry seeks novel biological alternatives to replace chemical compounds and improve product qualities. Most of these chemicals have a biological origin and can be obtained from plant, bacterial, fungal, and algal sources. Various biological molecules have intriguing capabilities, such as biosurfactants, vitamins, antioxidants, pigments, enzymes, and peptides. These are safe, biodegradable, and environmentally friendly than chemical options. Plant-bas...
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IET Nanobiotechnology
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Objectives: Depo-Provera is a widely known brand name for medroxyprogesterone acetate. It has som... more Objectives: Depo-Provera is a widely known brand name for medroxyprogesterone acetate. It has some adverse effects which is reversible after discontinuation include changes in bleeding patterns and bone mineral density loss risk of weight gain in obese adolescents. The study aims to investigate the effects of Depo-Provera on body weight and blood pressure of Ethiopian women. Institutional based cross-sectional study design was conducted. The data was analyzed using SPSS version 21 software packages. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. The p-values less than 0.05 were considered as statistically significant. Results The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p-value-0.02 and p-value-0.019 respectively). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera...
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Background Noncommunicable diseases, such as cardiovascular diseases, continue to be the leading ... more Background Noncommunicable diseases, such as cardiovascular diseases, continue to be the leading cause of morbidity and mortality around the world. Hypertension and dyslipidemia appear to be the two most important modifiable risk factors contributing to the global rise in cardiovascular disease. Several plant preparations are currently being touted as having benefits for such cardiovascular risk factors. African moringa, Moringa stenopetala, is one of these plants used in Ethiopia. Therefore, this study aimed to assess and compare the serum lipid profiles and blood pressure measurements of Moringa stenopetala herbal tea drinkers and non-drinker hypertensive patients attending chronic care follow-up at Bale zone hospitals. Methods A comparative cross-sectional study, involving 128 blood samples (64 each of Moringa stenopetala herbal tea drinkers and nondrinkers), was conducted on hypertensive patients who were on chronic care follow-up from July 1 to August 30, 2021. A face-to-face i...
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PLOS ONE, Aug 8, 2022
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SAGE Open Medicine
Objectives: The purpose of conducting this study was to assess fatty liver disease and its correl... more Objectives: The purpose of conducting this study was to assess fatty liver disease and its correlation with glycemic control in type 2 diabetes mellitus patients. In addition, evaluation of associated factors and correlation analysis between the fatty liver index and hemoglobin A1C level in patients with type 2 diabetes mellitus was another aim of this study. Methods: A hospital-based cross-sectional study was conducted among type 2 diabetes mellitus patients attending at diabetes clinic of Dessie Comprehensive Specialized Hospital located in south Wollo, Ethiopia. It was conducted from July to August 2021. The fatty liver index was calculated to assess fatty liver disease. Simple descriptive statistics, multivariate analysis, and an independent sample t-test were utilized for statistical analysis. Multiple logistic regression analysis was used to determine the associated factors of fatty liver. The p value < 0.05 was considered as statistically significant. Results: In this stud...
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Medicinal Plants of the Asteraceae Family, 2022
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Additional file 1.
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Swertia (Gentianaceae), a diverse genus, is mentioned as a potential herbal drug in Ayurvedic, Un... more Swertia (Gentianaceae), a diverse genus, is mentioned as a potential herbal drug in Ayurvedic, Unani, and Siddha traditional systems of medicine. Since time immemorial, 70 Swertia species have been used worldwide to cure several health illnesses associated with malaria, cancer, diabetes, inflammation, liver complications, different kinds of fever, etc. Swertia herb is used as the principal component in several marketed herbal/polyherbal formulations. Medicinal usage of Swertia is endorsed to the miscellaneous compounds, viz. xanthones, iridoids, seco-iridoids, and triterpenoids. Swertia is one of the most imperative trade herbs since its market value rises by 10% yearly. A chain of systematic isolation of bioactive compounds and their diverse range of pharmacological effects during the last 10–15 years proved this genus as an industrially important plant. This chapter makes an effort to present the comprehensive assessment on distribution, ethnopharmacology, biological activities, p...
Bookmarks Related papers MentionsView impact
Biotechnology for Biofuels and Bioproducts
Bioethanol is recognized as a valuable substitute for renewable energy sources to meet the fuel a... more Bioethanol is recognized as a valuable substitute for renewable energy sources to meet the fuel and energy demand of the nation, considered an environmentally friendly resource obtained from agricultural residues such as sugarcane bagasse, rice straw, husk, wheat straw and corn stover. The energy demand is sustained using lignocellulosic biomass to produce bioethanol. Lignocellulosic biomass (LCBs) is the point of attention in replacing the dependence on fossil fuels. The recalcitrant structure of the lignocellulosic biomass is disrupted using effective pretreatment techniques that separate complex interlinked structures among cellulose, hemicellulose, and lignin. Pretreatment of biomass involves various physical, chemical, biological, and physiochemical protocols which are of importance, dependent upon their individual or combined dissolution effect. Physical pretreatment involves a reduction in the size of the biomass using mechanical, extrusion, irradiation, and sonification meth...
Bookmarks Related papers MentionsView impact
Frontiers in Endocrinology
Alarin is a member of the galanin family of neuropeptides that is widely expressed in the central... more Alarin is a member of the galanin family of neuropeptides that is widely expressed in the central nervous system and peripheral tissues in humans and rodents. It was initially isolated fifteen years ago in ganglionic cells of human neuroblastoma. Subsequently, it was demonstrated to be broadly distributed in the blood vessels, skin, eyes, peripheral and central nervous systems, thymus, gastrointestinal tract, and endocrine organs of different species. Alarin is a 25 amino acid neuropeptide derived from the alternative splicing of the GALP gene, missing exon 3. It is found to be involved in several physiological functions that include feeding behavior, energy homeostasis, glucose homeostasis, body temperature, and reproduction. It has also vasoactive, anti-inflammatory, anti-edema, and antimicrobial activities. However, the physiological effects of alarin have not been fully elucidated and the receptors that mediate these effects are not currently known. Unearthing the novel biologic...
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South African Journal of Botany
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Bioactive Natural products in Drug Discovery , 2020
Cinnamon (Ceylon cinnamon or true cinnamon) is a popular, expensive aromatic condiment and flavor... more Cinnamon (Ceylon cinnamon or true cinnamon) is a popular, expensive aromatic condiment and flavoring agent cum medicinal plant that houses a major number of pharmaceutically active aromatic essential oils and its principal compound cinnamaldehyde, and its derivatives cinnamic acid, cinnamate, etc. In addition to its culinary use, in ancient Ayurvedic texts as well as in folkloric medicine, this plant and precisely the bark and bark powder have been reported as a remedy for respiratory, digestive, and gynecological ailments. It has been evaluated clinically and preclinically for its prominent antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer, lipid-lowering, and cardio- and neuroprotective efficacies. Commercially this plant is highly valued in the pharmaceutical and cosmetic industry. We have summarized the recent relevant scientific evidence on the botanic characterization, distribution, traditional uses, pharmacological activities, phytochemistry, qualitative and quantitative estimation and extraction of important secondary metabolites, genetic diversity assessment, biotechnological breakthroughs, cultivation, and propagation along with industrial application and clinical studies of Cinnamon species to assess future perspectives for Cinnamon as a pharmacologically leading genus of interest. Secondary metabolite extraction, isolation, and identification using HPTLC, LC-MS, HPLC, and GC-MS, along with genetic diversity assessment through molecular markers and biotechnological advancement (in vitro culture, embryo rescue, genetic transformation, molecular marker-based polymorphism assessment) contributing collectively to cinnamon improvement programs, are conclusively studied and reported in association with phytochemical and pharmacological discoveries via clinical and preclinical trials. The implementation of collective knowledge of research in areas of chemical biology, biotechnology, and pharmacology will directly benefit cost-effective breeding and cultivation program and establishment of encyclopedic database on various fields associated with Cinnamon research, aid in selection of industrially profitable elite germplasm with improved screening and harvesting protocols for Cinnamon-derived components, and elucidate a vast role of Cinnamon as an integral compound of complementary and alternative medicine.
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Bioactive Natural products in Drug Discovery, 2020
Swertia (Gentianaceae), a diverse genus, is mentioned as a potential herbal drug in Ayurvedic, Un... more Swertia (Gentianaceae), a diverse genus, is mentioned as a potential herbal drug in Ayurvedic, Unani, and Siddha traditional systems of medicine. Since time immemorial, 70 Swertia species have been used worldwide to cure several health illnesses associated with malaria, cancer, diabetes, inflammation, liver complications, different kinds of fever, etc. Swertia herb is used as the principal component in several marketed herbal/polyherbal formulations. Medicinal usage of Swertia is endorsed to the miscellaneous compounds, viz. xanthones, iridoids, seco-iridoids, and triterpenoids. Swertia is one of the most imperative trade herbs since its market value rises by 10% yearly. A chain of systematic isolation of bioactive compounds and their diverse range of pharmacological effects during the last 10–15 years proved this genus as an industrially important plant. This chapter makes an effort to present the comprehensive assessment on distribution, ethnopharmacology, biological activities, phytochemistry, extraction, and analysis of major bioactive compounds in selected species of Swertia in the past few years, and thus to explore the conventional and nonconventional ways of isolation and evaluation of pharmacologically significant bioactive compounds and to screen out the elite variety of Swertia spp.
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