| dbo:abstract |
La subunitat 50S és la més gran de les subunitats del ribosoma dels procariotes, 70S. Inclou l' i l'. (ca) La sous-unité ribosomique 50S est la plus grande des deux sous-unités constituant les ribosomes des procaryotes. Il s'agit d'un complexe ribonucléoprotéique constitué de deux ARN ribosomiques — l'ARNr 23S et l'ARNr 5S — et de protéines ribosomiques. Elle est la cible d'antibiotiques tels que les macrolides, le chloramphénicol, la clindamycine et les (en). Elle intervient dans la formation de la liaison peptidique entre les acides aminés lors de la biosynthèse des protéines par le ribosome, empêche l'hydrolyse prématurée du polypeptide en cours de croissance, fournit un site de liaison aux facteurs de protéines G (assistance à l'amorçage, à la croissance et à la terminaison du polypeptide) et assiste le repliement des protéines nouvellement synthétisées. (fr) 50S is the larger subunit of the 70S ribosome of prokaryotes, i.e. bacteria and archaea. It is the site of inhibition for antibiotics such as macrolides, chloramphenicol, clindamycin, and the pleuromutilins. It includes the 5S ribosomal RNA and 23S ribosomal RNA. Despite having the same sedimentation rate, bacterial and archaeal archaeal ribosomes can be quite different. (en) 50核糖体亚基是原核细胞内中的较大亚基。该亚基由一条5S rRNA、一条23S rRNA及约34个核糖体蛋白质分子构成，在原核轉译中负责在tRNA转运来的氨基酸分子之间形成肽键。50S核核糖体亚基是某些抗生素（如氯霉素、及等）的结合位点，这些抗生素可通过阻断蛋白质生物合成来杀灭细菌。 (zh) |
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http://pathmicro.med.sc.edu/mayer/antibiot.htm https://web.archive.org/web/20080206051722/http:/www.riboworld.com/antib/50santib-eng.shtml https://web.archive.org/web/20110227235620/http:/www.molgen.mpg.de/~ag_ribo/ag_franceschi/franceschi-projects-50S-antibiotics.html |
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La subunitat 50S és la més gran de les subunitats del ribosoma dels procariotes, 70S. Inclou l' i l'. (ca) 50S is the larger subunit of the 70S ribosome of prokaryotes, i.e. bacteria and archaea. It is the site of inhibition for antibiotics such as macrolides, chloramphenicol, clindamycin, and the pleuromutilins. It includes the 5S ribosomal RNA and 23S ribosomal RNA. Despite having the same sedimentation rate, bacterial and archaeal archaeal ribosomes can be quite different. (en) 50核糖体亚基是原核细胞内中的较大亚基。该亚基由一条5S rRNA、一条23S rRNA及约34个核糖体蛋白质分子构成，在原核轉译中负责在tRNA转运来的氨基酸分子之间形成肽键。50S核核糖体亚基是某些抗生素（如氯霉素、及等）的结合位点，这些抗生素可通过阻断蛋白质生物合成来杀灭细菌。 (zh) La sous-unité ribosomique 50S est la plus grande des deux sous-unités constituant les ribosomes des procaryotes. Il s'agit d'un complexe ribonucléoprotéique constitué de deux ARN ribosomiques — l'ARNr 23S et l'ARNr 5S — et de protéines ribosomiques. Elle est la cible d'antibiotiques tels que les macrolides, le chloramphénicol, la clindamycine et les (en). (fr) |
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50S (ca) Sous-unité ribosomique 50S (fr) Prokaryotic large ribosomal subunit (en) 50S核糖体亚基 (zh) |
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