| dbo:abstract |
Alazocine (developmental code name SKF-10047), also known more commonly as N-allylnormetazocine (NANM), is a synthetic opioid analgesic of the benzomorphan family related to metazocine, which was never marketed. In addition to its opioid activity, the drug is a sigma receptor agonist, and has been used widely in scientific research in studies of this receptor. Alazocine is described as a potent analgesic, psychotomimetic or hallucinogen, and opioid antagonist. Moreover, one of its enantiomers was the first compound that was found to selectively label the σ1 receptor, and led to the discovery and characterization of the receptor. (en) アラゾシン（英: alazocine、開発コード: SKF-10047）は、と関連したベンゾモルファン系の合成オピオイド鎮痛剤であり、市販されたことはない。N-アリルノルメタゾシン（N-allylnormetazocine、NANM）の名称でも一般的に知られる。オピオイド活性に加えて、のアゴニストでもあり、この受容体の研究に広く利用されている。アラゾシンは強力な鎮痛剤、、幻覚剤、モルヒネ様物質、として記載されている。さらに、エナンチオマーの1つはを選択的に標識することが発見された最初の化合物であり、この受容体の発見と特徴づけを導いた。 (ja) L'alazocina (noto nel corso del suo sviluppo con il nome di SKF -10047), noto anche più comunemente come N -allilnormetazocina ( NANM ), è un analgesico oppiaceo sintetico della famiglia benzomorpana correlato alla metazocina, che non è mai stato commercializzato. Oltre alla sua attività oppioide, il farmaco è un agonista del recettore sigma ed è stato ampiamente utilizzato nella ricerca scientifica negli studi di questo recettore. L'alazocina è descritta come un potente analgesico, psicotomimetico o allucinogeno e morfina o antagonista degli oppioidi . Inoltre, uno dei suoi enantiomeri è stato il primo composto che è stato trovato per etichettare selettivamente il recettore sigma σ 1 e ha portato alla scoperta e alla caratterizzazione del recettore. (it) |
| dbo:casNumber |
133005-41-1 ((+)-isomer) 14198-28-8 ((–)-isomer) 34061-23-9 (hydrochloride) 58640-82-7 ((+)-isomer) 74957-58-7 ((–)-isomer) 825594-24-9 |
| dbo:chEMBL |
274099 |
| dbo:fdaUniiCode |
L884482HDD |
| dbo:pubchem |
1235 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Alazocine.svg?width=300 |
| dbo:wikiPageID |
20511523 (xsd:integer) |
| dbo:wikiPageLength |
13674 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1083383806 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Potency_(pharmacology) dbr:Psychotomimetic dbr:Scientific_literature dbr:Enantiomer dbr:Mouse dbr:Partial_agonist dbr:Benzomorphan dbr:Pentazocine dbr:EC50 dbr:Intrinsic_activity dbr:Δ-opioid_receptor dbc:Analgesics dbc:NMDA_receptor_antagonists dbc:Phenols dbr:Opioid_receptor dbr:Brain dbr:Nalorphine dbr:Opioid_antagonist dbc:Kappa-opioid_receptor_agonists dbc:Mu-opioid_receptor_antagonists dbr:Ligand dbr:Stereoisomer dbr:Receptor_antagonist dbr:Pharmacodynamics dbc:Benzomorphans dbc:Delta-opioid_receptor_agonists dbr:Agonist dbr:Analgesic dbc:Allylamines dbc:Sigma_agonists dbr:Cyclazocine dbr:Cell_membrane dbr:Scientific_research dbc:Dissociative_drugs dbr:Guinea_pig dbr:Hallucinogen dbr:Haloperidol dbr:Hydrochloride dbr:Μ-opioid_receptor dbr:Affinity_(pharmacology) dbr:Binding_selectivity dbr:Ditolylguanidine dbr:Dizocilpine dbr:Phenazocine dbr:Phencyclidine dbr:HEK293 dbr:Metazocine dbr:Opioid dbr:Radiolabel dbr:Rat dbr:Sigma_receptor dbr:Stereoselectivity dbr:IC50 dbr:Κ-opioid_receptor dbr:NMDA_receptor_antagonist dbr:NMDA_receptor dbr:Transfection dbr:Sigma-2_receptor dbr:Uncompetitive_antagonist dbr:Sigma-1_receptor dbr:PC12_cell_line dbr:Radioligand_binding_assay dbr:Synthetic_compound dbr:(+)-3-PPP |
| dbp:atcPrefix |
None (en) |
| dbp:c |
17 (xsd:integer) |
| dbp:casNumber |
825594 (xsd:integer) |
| dbp:casSupplemental |
14198 (xsd:integer) 34061 (xsd:integer) 58640 (xsd:integer) 74957 (xsd:integer) 133005 (xsd:integer) |
| dbp:chembl |
274099 (xsd:integer) |
| dbp:chemspiderid |
1198 (xsd:integer) |
| dbp:h |
23 (xsd:integer) |
| dbp:iupacName |
-123456 (xsd:integer) |
| dbp:n |
1 (xsd:integer) |
| dbp:o |
1 (xsd:integer) |
| dbp:pubchem |
1235 (xsd:integer) |
| dbp:smiles |
CC1C2CC3=CC=CO (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
LGQCVMYAEFTEFN-UHFFFAOYSA-N (en) |
| dbp:synonyms |
SKF-10047; WIN-19631; N-Allylnormetazocine; NANM; NAN; ANMC; 2'-Hydroxy-5,9-dimethyl-2-allyl-6,7-benzomorphan (en) |
| dbp:unii |
L884482HDD (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
477316370 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:width |
185 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Abbr dbt:Distinguish dbt:Drugbox dbt:Hallucinogens dbt:Ionotropic_glutamate_receptor_modulators dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Opioid_receptor_modulators dbt:Sigma_receptor_modulators |
| dcterms:subject |
dbc:Analgesics dbc:NMDA_receptor_antagonists dbc:Phenols dbc:Kappa-opioid_receptor_agonists dbc:Mu-opioid_receptor_antagonists dbc:Benzomorphans dbc:Delta-opioid_receptor_agonists dbc:Allylamines dbc:Sigma_agonists dbc:Dissociative_drugs |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Substance100019613 yago:WikicatPhenols umbel-rc:ChemicalSubstanceType |
| rdfs:comment |
Alazocine (developmental code name SKF-10047), also known more commonly as N-allylnormetazocine (NANM), is a synthetic opioid analgesic of the benzomorphan family related to metazocine, which was never marketed. In addition to its opioid activity, the drug is a sigma receptor agonist, and has been used widely in scientific research in studies of this receptor. Alazocine is described as a potent analgesic, psychotomimetic or hallucinogen, and opioid antagonist. Moreover, one of its enantiomers was the first compound that was found to selectively label the σ1 receptor, and led to the discovery and characterization of the receptor. (en) アラゾシン（英: alazocine、開発コード: SKF-10047）は、と関連したベンゾモルファン系の合成オピオイド鎮痛剤であり、市販されたことはない。N-アリルノルメタゾシン（N-allylnormetazocine、NANM）の名称でも一般的に知られる。オピオイド活性に加えて、のアゴニストでもあり、この受容体の研究に広く利用されている。アラゾシンは強力な鎮痛剤、、幻覚剤、モルヒネ様物質、として記載されている。さらに、エナンチオマーの1つはを選択的に標識することが発見された最初の化合物であり、この受容体の発見と特徴づけを導いた。 (ja) L'alazocina (noto nel corso del suo sviluppo con il nome di SKF -10047), noto anche più comunemente come N -allilnormetazocina ( NANM ), è un analgesico oppiaceo sintetico della famiglia benzomorpana correlato alla metazocina, che non è mai stato commercializzato. Oltre alla sua attività oppioide, il farmaco è un agonista del recettore sigma ed è stato ampiamente utilizzato nella ricerca scientifica negli studi di questo recettore. L'alazocina è descritta come un potente analgesico, psicotomimetico o allucinogeno e morfina o antagonista degli oppioidi . Inoltre, uno dei suoi enantiomeri è stato il primo composto che è stato trovato per etichettare selettivamente il recettore sigma σ 1 e ha portato alla scoperta e alla caratterizzazione del recettore. (it) |
| rdfs:label |
Alazocine (en) Alazocina (it) アラゾシン (ja) |
| owl:differentFrom |
dbr:N-Allylnormorphine |
| owl:sameAs |
freebase:Alazocine yago-res:Alazocine wikidata:Alazocine dbpedia-it:Alazocine dbpedia-ja:Alazocine dbpedia-sh:Alazocine dbpedia-sr:Alazocine https://global.dbpedia.org/id/4N6Fm |
| prov:wasDerivedFrom |
wikipedia-en:Alazocine?oldid=1083383806&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Alazocine.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Alazocine |
| is dbo:wikiPageRedirects of |
dbr:(–)-Alazocine dbr:SK&F-10,047 dbr:SK&F-10047 dbr:SK&F10,047 dbr:SK&F10047 dbr:SK&F_10,047 dbr:SK&F_10047 dbr:SKF-10,047 dbr:SKF-10,047_hydrochloride dbr:SKF-10047 dbr:SKF-10047_hydrochloride dbr:SKF10,047 dbr:SKF10047 dbr:SKF10047_hydrochloride dbr:SKF_10,047 dbr:SKF_10047 dbr:Alazocine_hydrochloride dbr:Allyl-normetazocine dbr:Allylnormetazocine dbr:Allylnormetazocine_hydrochloride dbr:ANMC dbr:N-Allyl-normetazocine dbr:N-Allylnormetazocine dbr:N-Allylnormetazocine_hydrochloride dbr:N-allyl-normetazocine dbr:N-allylnormetazocine dbr:N-allylnormetazocine_hydrochloride dbr:NANM dbr:(+)-Alazocine dbr:(+)-Allylnormetazocine dbr:(+)-N-Allylnormetazocine dbr:(+)-N-allylnormetazocine dbr:(+)-NANM dbr:(+)-SKF-10,047 dbr:(+)-SKF-10047 dbr:(+)-SKF10,047 dbr:(+)-SKF10047 dbr:(+)-SKF_10,047 dbr:(+)-SKF_10047 dbr:(+)-alazocine dbr:(+)-allylnormetazocine dbr:(-)-Alazocine dbr:(-)-Allylnormetazocine dbr:(-)-N-Allylnormetazocine dbr:(-)-N-allylnormetazocine dbr:(-)-NANM dbr:(-)-SKF-10,047 dbr:(-)-SKF-10047 dbr:(-)-SKF10,047 dbr:(-)-SKF10047 dbr:(-)-SKF_10,047 dbr:(-)-SKF_10047 dbr:(-)-alazocine dbr:(-)-allylnormetazocine dbr:(_)-Allylnormetazocine dbr:(_)-allylnormetazocine dbr:(±)-Alazocine dbr:(±)-Allylnormetazocine dbr:(±)-N-Allylnormetazocine dbr:(±)-N-allylnormetazocine dbr:(±)-NANM dbr:(±)-SKF-10,047 dbr:(±)-SKF-10047 dbr:(±)-SKF10,047 dbr:(±)-SKF10047 dbr:(±)-SKF_10,047 dbr:(±)-SKF_10047 dbr:(±)-alazocine dbr:(±)-allylnormetazocine dbr:(–)-Allylnormetazocine dbr:(–)-N-Allylnormetazocine dbr:(–)-N-allylnormetazocine dbr:(–)-NANM dbr:(–)-SKF-10,047 dbr:(–)-SKF-10047 dbr:(–)-SKF10,047 dbr:(–)-SKF10047 dbr:(–)-SKF_10,047 dbr:(–)-SKF_10047 dbr:(–)-alazocine dbr:(–)-allylnormetazocine dbr:(−)-Alazocine dbr:WIN-19,631 dbr:WIN-19631 dbr:WIN19,631 dbr:WIN19631 dbr:WIN_19,631 dbr:WIN_19631 |
| is dbo:wikiPageWikiLink of |
dbr:Benzomorphan dbr:List_of_opioids dbr:(–)-Alazocine dbr:3-PPP dbr:C17H23NO dbr:Spiradoline dbr:Opioid dbr:Κ-opioid_receptor dbr:SK&F-10,047 dbr:SK&F-10047 dbr:SK&F10,047 dbr:SK&F10047 dbr:SK&F_10,047 dbr:SK&F_10047 dbr:SKF-10,047 dbr:SKF-10,047_hydrochloride dbr:SKF-10047 dbr:SKF-10047_hydrochloride dbr:SKF10,047 dbr:SKF10047 dbr:SKF10047_hydrochloride dbr:SKF_10,047 dbr:SKF_10047 dbr:Alazocine_hydrochloride dbr:Allyl-normetazocine dbr:Allylnormetazocine dbr:Allylnormetazocine_hydrochloride dbr:ANMC dbr:N-Allyl-normetazocine dbr:N-Allylnormetazocine dbr:N-Allylnormetazocine_hydrochloride dbr:N-allyl-normetazocine dbr:N-allylnormetazocine dbr:N-allylnormetazocine_hydrochloride dbr:NANM dbr:(+)-Alazocine dbr:(+)-Allylnormetazocine dbr:(+)-N-Allylnormetazocine dbr:(+)-N-allylnormetazocine dbr:(+)-NANM dbr:(+)-SKF-10,047 dbr:(+)-SKF-10047 dbr:(+)-SKF10,047 dbr:(+)-SKF10047 dbr:(+)-SKF_10,047 dbr:(+)-SKF_10047 dbr:(+)-alazocine dbr:(+)-allylnormetazocine dbr:(-)-Alazocine dbr:(-)-Allylnormetazocine dbr:(-)-N-Allylnormetazocine dbr:(-)-N-allylnormetazocine dbr:(-)-NANM dbr:(-)-SKF-10,047 dbr:(-)-SKF-10047 dbr:(-)-SKF10,047 dbr:(-)-SKF10047 dbr:(-)-SKF_10,047 dbr:(-)-SKF_10047 dbr:(-)-alazocine dbr:(-)-allylnormetazocine dbr:(_)-Allylnormetazocine dbr:(_)-allylnormetazocine dbr:(±)-Alazocine dbr:(±)-Allylnormetazocine dbr:(±)-N-Allylnormetazocine dbr:(±)-N-allylnormetazocine dbr:(±)-NANM dbr:(±)-SKF-10,047 dbr:(±)-SKF-10047 dbr:(±)-SKF10,047 dbr:(±)-SKF10047 dbr:(±)-SKF_10,047 dbr:(±)-SKF_10047 dbr:(±)-alazocine dbr:(±)-allylnormetazocine dbr:(–)-Allylnormetazocine dbr:(–)-N-Allylnormetazocine dbr:(–)-N-allylnormetazocine dbr:(–)-NANM dbr:(–)-SKF-10,047 dbr:(–)-SKF-10047 dbr:(–)-SKF10,047 dbr:(–)-SKF10047 dbr:(–)-SKF_10,047 dbr:(–)-SKF_10047 dbr:(–)-alazocine dbr:(–)-allylnormetazocine dbr:(−)-Alazocine dbr:WIN-19,631 dbr:WIN-19631 dbr:WIN19,631 dbr:WIN19631 dbr:WIN_19,631 dbr:WIN_19631 |
| is foaf:primaryTopic of |
wikipedia-en:Alazocine |
