| dbo:abstract |
Allantoicase is an enzyme (EC 3.5.3.4) that in humans is encoded by the ALLC gene. Allantoicase catalyzes the chemical reaction allantoate + H2O (S)-ureidoglycolate + urea Thus, the two substrates of this enzyme are allantoate and H2O, whereas its two products are and urea. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is allantoate amidinohydrolase. This enzyme participates in purine metabolism by facilitating the utilization of purines as secondary nitrogen sources under nitrogen-limiting conditions. While purine degradation converges to uric acid in all vertebrates, its further degradation varies from species to species. Uric acid is excreted by birds, reptiles, and some mammals that do not have a functional uricase gene, whereas other mammals produce allantoin. Amphibians and microorganisms produce ammonia and carbon dioxide using the uricolytic pathway. Allantoicase performs the second step in this pathway catalyzing the conversion of allantoate into ureidoglycolate and urea. (en) |
| dbo:ecNumber |
3.5.3.4 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/1sg3.jpg?width=300 |
| dbo:wikiPageID |
14501947 (xsd:integer) |
| dbo:wikiPageLength |
5581 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1038540910 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Carbon_dioxide dbr:Catalyst dbr:Purine dbr:List_of_enzymes dbr:Nitrogen dbr:Antiparallel_(biochemistry) dbr:Urea dbr:Uric_acid dbc:Enzymes_of_known_structure dbr:Chemical_reaction dbr:Enzyme dbr:Gene dbr:Mammal dbr:Mammals dbr:Protein_Data_Bank dbr:Substrate_(biochemistry) dbr:Tandem_repeat dbr:Active_site dbc:EC_3.5.3 dbr:Ammonia dbr:Amphibian dbr:Protein_folding dbr:Product_(chemistry) dbr:Hydrolase dbr:Tertiary_structure dbr:Purine_metabolism dbr:Catalysis dbr:Water dbr:Vertebrates dbr:Secondary_structure dbr:Allantoate dbr:Beta-sheet dbr:(S)-ureidoglycolate |
| dbp:caption |
Allantoicase homohexamer, Saccharomyces cerevisiae (en) structure of allantoicase (en) |
| dbp:casNumber |
9025 (xsd:integer) |
| dbp:ecNumber |
3.500000 (xsd:double) |
| dbp:goCode |
4037 (xsd:integer) |
| dbp:interpro |
IPR015908 (en) |
| dbp:iubmbEcNumber |
3 (xsd:integer) |
| dbp:name |
Allantoicase (en) allantoicase (en) |
| dbp:pfam |
PF03561 (en) |
| dbp:pfamClan |
CL0202 (en) |
| dbp:scop |
1 (xsd:integer) |
| dbp:symbol |
Allantoicase (en) |
| dbp:width |
270 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Carbon-nitrogen_non-peptide_hydrolases dbt:Cite_journal dbt:EC_number dbt:Enzyme dbt:Enzymes dbt:Infobox_protein_family dbt:InterPro_content dbt:PDB_link dbt:Portal_bar dbt:Reflist |
| dcterms:subject |
dbc:Enzymes_of_known_structure dbc:EC_3.5.3 |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Enzyme yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment |
Allantoicase is an enzyme (EC 3.5.3.4) that in humans is encoded by the ALLC gene. Allantoicase catalyzes the chemical reaction allantoate + H2O (S)-ureidoglycolate + urea Thus, the two substrates of this enzyme are allantoate and H2O, whereas its two products are and urea. (en) |
| rdfs:label |
Allantoicase (en) |
| owl:sameAs |
freebase:Allantoicase wikidata:Allantoicase dbpedia-sh:Allantoicase dbpedia-sr:Allantoicase https://global.dbpedia.org/id/4Nady |
| prov:wasDerivedFrom |
wikipedia-en:Allantoicase?oldid=1038540910&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/1sg3.jpg wiki-commons:Special:FilePath/PDB_1sg3_EBI.jpg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Allantoicase |
| foaf:name |
allantoicase (en) |
| is dbo:wikiPageRedirects of |
dbr:ALLC_(gene) dbr:EC_3.5.3.4 dbr:Allantoate_amidinohydrolase |
| is dbo:wikiPageWikiLink of |
dbr:List_of_EC_numbers_(EC_3) dbr:ALLC_(gene) dbr:EC_3.5.3.4 dbr:Allantoate_amidinohydrolase |
| is foaf:primaryTopic of |
wikipedia-en:Allantoicase |
