| dbo:abstract |
The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6. BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion. They are typically composed of 4-5 alpha helices and a three-stranded beta sheet. (en) |
| dbo:symbol |
BIR |
| dbo:thumbnail |
wiki-commons:Special:FilePath/1QBH_BIRC2.png?width=300 |
| dbo:wikiPageID |
21533163 (xsd:integer) |
| dbo:wikiPageLength |
3443 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
993335693 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:BIRC2 dbr:BIRC6 dbr:NAIP_(gene) dbr:Protein_nuclear_magnetic_resonance_spectroscopy dbr:Structural_motif dbr:Beta_sheet dbr:Cytokine dbr:Inhibitor_of_apoptosis dbr:Apoptosis dbr:Zinc dbr:Alpha_helix dbr:Amino_acid dbc:Protein_structural_motifs dbr:Cysteine dbr:Chromosome_segregation dbr:Protein dbc:Protein_domains dbr:Histidine dbr:Survivin dbr:C-terminus dbr:XIAP dbr:N-terminus dbr:BIRC3 dbr:Zinc-finger |
| dbp:caption |
NMR solution structure of the BIR domain of human BIRC2 protein. The protein is rainbow colored cartoon diagram while the coordinated zinc is represented by a grey sphere. (en) |
| dbp:interpro |
IPR001370 (en) |
| dbp:name |
Inhibitor of Apoptosis domain (en) |
| dbp:pdb |
, , , , , , , , , , , , , , , , , , , , , , , , , , (en) |
| dbp:pfam |
PF00653 (en) |
| dbp:prosite |
PS50143 (en) |
| dbp:scop |
1 (xsd:integer) |
| dbp:symbol |
BIR (en) |
| dbp:wikiPageUsesTemplate |
dbt:ELM dbt:InterPro_content dbt:Reflist dbt:PDB2 dbt:Protein_domains dbt:Pfam_box |
| dcterms:subject |
dbc:Protein_structural_motifs dbc:Protein_domains |
| gold:hypernym |
dbr:Motif |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Artifact100021939 yago:Decoration103169390 yago:Design103178782 yago:Motif103789014 yago:Object100002684 yago:PhysicalEntity100001930 dbo:Protein yago:Whole100003553 yago:WikicatProteinStructuralMotifs |
| rdfs:comment |
The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6. (en) |
| rdfs:label |
Inhibitor of apoptosis domain (en) |
| owl:sameAs |
freebase:Inhibitor of apoptosis domain yago-res:Inhibitor of apoptosis domain wikidata:Inhibitor of apoptosis domain dbpedia-sh:Inhibitor of apoptosis domain dbpedia-sr:Inhibitor of apoptosis domain https://global.dbpedia.org/id/2LE2J |
| prov:wasDerivedFrom |
wikipedia-en:Inhibitor_of_apoptosis_domain?oldid=993335693&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/1QBH_BIRC2.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Inhibitor_of_apoptosis_domain |
| is dbo:wikiPageRedirects of |
dbr:BIR_domain dbr:Baculoviral_IAP_repeat dbr:BIRP dbr:BIR_repeat dbr:Baculovirus_Inhibitor_of_apoptosis_protein_Repeat dbr:IAP_repeat |
| is dbo:wikiPageWikiLink of |
dbr:BIR dbr:BIR_domain dbr:Baculoviral_IAP_repeat dbr:NOD-like_receptor dbr:Death_regulator_Nedd2-like_caspase dbr:Inhibitor_of_apoptosis dbr:Cellular_Inhibitor_of_Apoptosis_Protein_1 dbr:Survivin dbr:XIAP dbr:Outline_of_immunology dbr:BIRP dbr:BIR_repeat dbr:Baculovirus_Inhibitor_of_apoptosis_protein_Repeat dbr:IAP_repeat |
| is foaf:primaryTopic of |
wikipedia-en:Inhibitor_of_apoptosis_domain |
