| dbo:abstract |
Etynodiol diacetate, or ethynodiol diacetate, sold under the brand names Demulen and Femulen among others, is a progestin medication which is used in birth control pills. The medication is available only in combination with an estrogen. It is taken by mouth. Etynodiol diacetate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak androgenic and estrogenic activity and no other important hormonal activity. The medication is a prodrug of norethisterone in the body, with etynodiol occurring as an intermediate. Etynodiol, a related compound, was discovered in 1954, and etynodiol diacetate was introduced for medical use in 1965. The medication remains available today only in the United States, Canada, and a few other countries. (en) L'etinodiolo diacetato è un farmaco progestinico (agonista progestinico di prima generazione) in precedenza usato nella contraccezione e/o nei disordini ormonali femminili. Possiede uno scarso effetto androgenizzante e un peculiare effetto estrogeno-simile. (it) |
| dbo:alternativeName |
Continuin, Demulen, Femulen, Luteonorm, Luto-Metrodiol, Metrodiol, Ovulen, others (en) |
| dbo:atcCode |
(with anestrogen) |
| dbo:casNumber |
297-76-7 8056-92-6 |
| dbo:chEBI |
31580 |
| dbo:chEMBL |
1200624 |
| dbo:class |
dbr:Progestin dbr:Progestogen_(medication) dbr:Progestogen_ester |
| dbo:drugbank |
DB00823 |
| dbo:fdaUniiCode |
62H10A1236 |
| dbo:kegg |
D01294 |
| dbo:pubchem |
9270 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Ethynodiol_diacetate.svg?width=300 |
| dbo:wikiPageID |
6657904 (xsd:integer) |
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14397 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1123036569 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Canada dbr:Progesterone dbr:Progestin dbr:Progestogen_(medication) dbr:Progestogen_ester dbr:Metabolic_intermediate dbr:Birth_control_pills dbr:Androgen dbr:Androgen_receptor dbr:United_States dbr:Dehydrogenation dbc:Acetate_esters dbc:Androgens_and_anabolic_steroids dbc:Estranes dbc:Ethynyl_compounds dbc:Prodrugs dbc:Progestogens dbc:Synthetic_estrogens dbr:Chemical_synthesis dbr:Ester dbr:Esterase dbr:Estrogen_(medication) dbr:Oral_administration dbc:Progestogen_esters dbr:Liver dbr:Steroid dbr:Functional_group dbr:Ketone dbr:Pharmacodynamics dbr:Prodrug dbr:Progesterone_receptor dbr:Acetate dbr:Agonist dbr:Estrane dbr:Ethinylestradiol dbr:Etynodiol dbr:Norethisterone dbr:Noretynodrel dbr:Generic_term dbr:Redox dbr:Testosterone_(medication) dbr:Argentina dbc:Merck_brands dbr:Affinity_(pharmacology) dbr:Biological_target dbr:Mestranol dbr:Oman dbr:Medicine dbr:Stereoselectivity dbr:Pharmacokinetics dbr:19-nortestosterone dbr:First-pass_metabolism dbr:Synthetic_compound dbr:Hydroxyl_group dbr:17α-ethynyltestosterone dbr:Chemical_derivative dbr:Combined_oral_contraceptives dbr:Hormonal_agent dbr:File:Ethynodiol_diacetate_synthesis.svg dbr:File:Norethisterone.svg |
| dbp:atcPrefix |
G03 (en) |
| dbp:atcSuffix |
DC06 (en) |
| dbp:c |
24 (xsd:integer) |
| dbp:casNumber |
297 (xsd:integer) |
| dbp:casSupplemental |
8056 (xsd:integer) |
| dbp:chebi |
31580 (xsd:integer) |
| dbp:chembl |
1200624 (xsd:integer) |
| dbp:chemspiderid |
8913 (xsd:integer) |
| dbp:class |
dbr:Progestin dbr:Progestogen_(medication) dbr:Progestogen_ester |
| dbp:drugbank |
DB00823 (en) |
| dbp:h |
32 (xsd:integer) |
| dbp:iupacName |
[-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate (en) |
| dbp:kegg |
D01294 (en) |
| dbp:legalStatus |
Rx-only (en) |
| dbp:o |
4 (xsd:integer) |
| dbp:pubchem |
9270 (xsd:integer) |
| dbp:pubchemsubstance |
46506993 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:smiles |
O=CC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
ONKUMRGIYFNPJW-KIEAKMPYSA-N (en) |
| dbp:synonyms |
Ethynodiol diacetate; Norethindrol diacetate; 3β-Hydroxynorethisterone 3β,17β-diacetate; 17α-Ethynylestr-4-ene-3β,17β-diyl diacetate; CB-8080; SC-11800 (en) |
| dbp:title |
dbr:Pharmacodynamics dbr:Medicine |
| dbp:titlestyle |
background:#ccccff (en) |
| dbp:tradename |
Continuin, Demulen, Femulen, Luteonorm, Luto-Metrodiol, Metrodiol, Ovulen, others (en) |
| dbp:unii |
62 (xsd:integer) |
| dbp:width |
250 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Relative_affinities_of_norethisterone,_metabolites,_and_prodrugs dbt:Androgen_receptor_modulators dbt:Clear dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Navboxes dbt:Progesterone_receptor_modulators dbt:Reflist dbt:See_also dbt:Short_description dbt:US_patent dbt:Abbrlink dbt:Fdacite dbt:Androgens_and_antiandrogens dbt:Estrogens_and_antiestrogens dbt:Progestogens_and_antiprogestogens dbt:ATC |
| dct:subject |
dbc:Acetate_esters dbc:Androgens_and_anabolic_steroids dbc:Estranes dbc:Ethynyl_compounds dbc:Prodrugs dbc:Progestogens dbc:Synthetic_estrogens dbc:Progestogen_esters dbc:Merck_brands |
| gold:hypernym |
dbr:Progestin |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatSteroids yago:Abstraction100002137 yago:Acetylene114600742 yago:AliphaticCompound114601294 yago:BodySubstance105263850 yago:Chemical114806838 yago:Compound114818238 yago:Ester114850483 yago:Estrogen114749794 yago:Hormone105407119 yago:LiquidBodySubstance105397468 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Progestin114747338 yago:Relation100031921 dbo:Drug yago:Secretion105404728 yago:Steroid115057744 yago:SteroidHormone114745635 yago:Substance100019613 yago:WikicatAcetateEsters yago:WikicatAlkynes yago:WikicatEstrogens yago:WikicatProgestogens umbel-rc:DrugProduct |
| rdfs:comment |
L'etinodiolo diacetato è un farmaco progestinico (agonista progestinico di prima generazione) in precedenza usato nella contraccezione e/o nei disordini ormonali femminili. Possiede uno scarso effetto androgenizzante e un peculiare effetto estrogeno-simile. (it) Etynodiol diacetate, or ethynodiol diacetate, sold under the brand names Demulen and Femulen among others, is a progestin medication which is used in birth control pills. The medication is available only in combination with an estrogen. It is taken by mouth. Etynodiol, a related compound, was discovered in 1954, and etynodiol diacetate was introduced for medical use in 1965. The medication remains available today only in the United States, Canada, and a few other countries. (en) |
| rdfs:label |
Etynodiol diacetate (en) Etinodiolo diacetato (it) |
| rdfs:seeAlso |
dbr:List_of_progestogens dbr:Norethisterone |
| owl:sameAs |
freebase:Etynodiol diacetate http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00823 yago-res:Etynodiol diacetate wikidata:Etynodiol diacetate dbpedia-cy:Etynodiol diacetate dbpedia-it:Etynodiol diacetate dbpedia-sh:Etynodiol diacetate dbpedia-sr:Etynodiol diacetate https://global.dbpedia.org/id/4jopM |
| prov:wasDerivedFrom |
wikipedia-en:Etynodiol_diacetate?oldid=1123036569&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Norethisterone.svg wiki-commons:Special:FilePath/Ethynodiol_diacetate.svg wiki-commons:Special:FilePath/Ethynodiol_diacetate_synthesis.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Etynodiol_diacetate |
| is dbo:wikiPageRedirects of |
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| is dbo:wikiPageWikiLink of |
dbr:Progestogen_(medication) dbr:Progestogen_ester dbr:List_of_androgens_and_anabolic_steroids dbr:Metynodiol dbr:Metynodiol_diacetate dbr:C24H32O4 dbr:List_of_progestogen_esters dbr:List_of_progestogens dbr:List_of_progestogens_available_in_the_United_States dbr:Combined_oral_contraceptive_pill dbr:Anagestone_acetate dbr:Frank_B._Colton dbr:Progestogen-only_pill dbr:Gallbladder_disease dbr:Ethynerone dbr:Etynodiol dbr:Norethisterone dbr:Noretynodrel dbr:Norsteroid dbr:List_of_MeSH_codes_(D04) dbr:ATC_code_G03DC06 dbr:ATCvet_code_QG03DC06 dbr:Femulen dbr:ATC_code_G03 dbr:Chlormadinone_acetate dbr:Birth_control_pill_formulations dbr:Continuin dbr:Nandrolone dbr:Cervicundin dbr:Ovulen dbr:Ovulen_50 dbr:Luteonorm dbr:Luto-Metrodiol dbr:Metrodiol dbr:Metrodiol_Diacetate dbr:Metrulen dbr:Ethynodiol_diacetate |
| is foaf:primaryTopic of |
wikipedia-en:Etynodiol_diacetate |
