| dbo:abstract |
Mestranol ist ein synthetischer Arzneistoff aus der Gruppe der Estrogene. Es ist ein Prodrug (eine inaktive Vorstufe) des häufig in Arzneimitteln zur Empfängnisverhütung eingesetzten Ethinylestradiols. (de) Mestranol, sold under the brand names Enovid, Norinyl, and Ortho-Novum among others, is an estrogen medication which has been used in birth control pills, menopausal hormone therapy, and the treatment of menstrual disorders. It is formulated in combination with a progestin and is not available alone. It is taken by mouth. Side effects of mestranol include nausea, breast tension, edema, and breakthrough bleeding among others. It is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. Mestranol is a prodrug of ethinylestradiol in the body. Mestranol was discovered in 1956 and was introduced for medical use in 1957. It was the estrogen component in the first birth control pill. In 1969, mestranol was replaced by ethinylestradiol in most birth control pills, although mestranol continues to be used in a few birth control pills even today. Mestranol remains available only in a few countries, including the United States, United Kingdom, Japan, and Chile. (en) O mestranol (DCI; nomes de marca: Devocin, Ovastol, Tranel, entre outros; também conhecido como etinilestradiol 3-metil éter, EEME, EE3ME) é um estrogênio esteroide sintético amplamente utilizado para fins contraceptivos. Foi empregado como o componente do estrogênico em muitos dos primeiros contraceptivos orais, tais como o mestranol / noretynodrel (nomes de tipo Enovid, Enavid), e é usado ainda hoje. Foi também um componente de Ortho-Novum, Ortho-Novin, Femigen, e Norbiogest. Além do seu uso como contraceptivo oral, o mestranol tem sido usado como um componente da terapia de reposição hormonal. (pt) |
| dbo:alternativeName |
Enovid, Norinyl, Ortho-Novum, others (en) |
| dbo:casNumber |
72-33-3 |
| dbo:chEBI |
6784 |
| dbo:chEMBL |
1201151 |
| dbo:class |
dbr:Estrogen_(medication) dbr:Estrogen_ether |
| dbo:drugbank |
DB01357 |
| dbo:fdaUniiCode |
B2V233XGE7 |
| dbo:kegg |
D00575 |
| dbo:medlinePlus |
a601050 |
| dbo:pubchem |
6291 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Mestranol.svg?width=300 |
| dbo:wikiPageID |
7721911 (xsd:integer) |
| dbo:wikiPageLength |
21992 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1123032923 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:California dbr:Progestin dbr:Puerto_Rico dbr:Menstrual_disorder dbr:Mestranol/noretynodrel dbr:Progestogen dbc:Hormonal_contraception dbr:United_Kingdom dbr:United_States dbr:In_vitro dbr:Menopause dbr:Libido dbc:Estranes dbc:Estrogen_ethers dbc:Ethynyl_compounds dbc:Prodrugs dbc:Synthetic_estrogens dbr:Combined_oral_contraceptive_pill dbr:Chemical_synthesis dbr:Estrogen_(medication) dbr:Nausea dbr:Oral_administration dbr:Elimination_half-life dbr:G.D._Searle,_LLC dbr:Liver dbr:Steroid dbr:Clinical_trial dbr:Demethylation dbr:Birth_control_pill dbr:Prodrug dbr:Symptom dbr:Estrogenic dbr:Ovulation dbr:Agonist dbr:Edema dbr:Estradiol dbr:Estradiol_(medication) dbr:Estrane dbr:Estrogen_receptor dbr:Ethinylestradiol dbr:Breakthrough_bleeding dbr:Breast_tension dbr:Norethisterone dbr:Noretynodrel dbr:Gonadotropin dbr:Generic_term dbr:Gynecomastia dbr:Japan dbr:Chile dbr:Biological_target dbr:Pharmacokinetic dbr:Mestranol/norethisterone dbr:Menopausal_hormone_therapy dbr:Methyl_group dbr:Side_effect dbr:Wastewater_treatment dbr:Ether dbr:Male_contraceptive dbr:Erectile_function dbr:Testicular_size dbr:Estrogen_ether dbr:Synthetic_compound dbr:Chemical_derivative dbr:Relative_binding_affinity dbr:Venous_thromboembolism dbr:Bioequivalent dbr:Sperm_count dbr:File:Ethinylestradiol.svg |
| dbp:atcPrefix |
None (en) |
| dbp:c |
21 (xsd:integer) |
| dbp:casNumber |
72 (xsd:integer) |
| dbp:chebi |
6784 (xsd:integer) |
| dbp:chembl |
1201151 (xsd:integer) |
| dbp:chemspiderid |
6054 (xsd:integer) |
| dbp:class |
dbr:Estrogen_(medication) dbr:Estrogen_ether |
| dbp:drugbank |
DB01357 (en) |
| dbp:eliminationHalfLife |
3000.0 (dbd:second) -129600.0 (dbd:second) |
| dbp:h |
26 (xsd:integer) |
| dbp:image |
Mestranol molecule ball.png (en) |
| dbp:iupacName |
-17 (xsd:integer) |
| dbp:iupharLigand |
7087 (xsd:integer) |
| dbp:kegg |
D00575 (en) |
| dbp:legalStatus |
Rx-only (en) |
| dbp:medlineplus |
a601050 (en) |
| dbp:metabolites |
dbr:Ethinylestradiol |
| dbp:o |
2 (xsd:integer) |
| dbp:pubchem |
6291 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:smiles |
OC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
IMSSROKUHAOUJS-MJCUULBUSA-N (en) |
| dbp:synonyms |
Ethinylestradiol 3-methyl ether; EEME; EE3ME; CB-8027; L-33355; RS-1044; 17α-Ethynylestradiol 3-methyl ether; 17α-Ethynyl-3-methoxyestra-1,3,5-trien-17β-ol; 3-Methoxy-19-norpregna-1,3,5-trien-20-yn-17β-ol (en) |
| dbp:tradename |
Enovid, Norinyl, Ortho-Novum, others (en) |
| dbp:unii |
B2V233XGE7 (en) |
| dbp:verifiedfields |
verified (en) |
| dbp:verifiedrevid |
462249106 (xsd:integer) |
| dbp:watchedfields |
verified (en) |
| dbp:width |
225 (xsd:integer) 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Abbr dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Reflist dbt:See_also dbt:Short_description dbt:Abbrlink dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Estrogens_and_antiestrogens dbt:Drugs.com dbt:Oral_potencies_of_estrogens dbt:Affinities_and_estrogenic_potencies_of..._and_ethers_at_the_estrogen_receptors |
| dct:subject |
dbc:Hormonal_contraception dbc:Estranes dbc:Estrogen_ethers dbc:Ethynyl_compounds dbc:Prodrugs dbc:Synthetic_estrogens |
| gold:hypernym |
dbr:Synthetic |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug umbel-rc:DrugProduct |
| rdfs:comment |
Mestranol ist ein synthetischer Arzneistoff aus der Gruppe der Estrogene. Es ist ein Prodrug (eine inaktive Vorstufe) des häufig in Arzneimitteln zur Empfängnisverhütung eingesetzten Ethinylestradiols. (de) O mestranol (DCI; nomes de marca: Devocin, Ovastol, Tranel, entre outros; também conhecido como etinilestradiol 3-metil éter, EEME, EE3ME) é um estrogênio esteroide sintético amplamente utilizado para fins contraceptivos. Foi empregado como o componente do estrogênico em muitos dos primeiros contraceptivos orais, tais como o mestranol / noretynodrel (nomes de tipo Enovid, Enavid), e é usado ainda hoje. Foi também um componente de Ortho-Novum, Ortho-Novin, Femigen, e Norbiogest. Além do seu uso como contraceptivo oral, o mestranol tem sido usado como um componente da terapia de reposição hormonal. (pt) Mestranol, sold under the brand names Enovid, Norinyl, and Ortho-Novum among others, is an estrogen medication which has been used in birth control pills, menopausal hormone therapy, and the treatment of menstrual disorders. It is formulated in combination with a progestin and is not available alone. It is taken by mouth. Side effects of mestranol include nausea, breast tension, edema, and breakthrough bleeding among others. It is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. Mestranol is a prodrug of ethinylestradiol in the body. (en) |
| rdfs:label |
Mestranol (de) Mestranol (en) Mestranol (pt) 美雌醇 (zh) |
| rdfs:seeAlso |
dbr:List_of_estrogens dbr:Ethinylestradiol |
| owl:sameAs |
freebase:Mestranol http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB01357 wikidata:Mestranol dbpedia-de:Mestranol dbpedia-fa:Mestranol dbpedia-pt:Mestranol dbpedia-sh:Mestranol dbpedia-sr:Mestranol dbpedia-vi:Mestranol dbpedia-zh:Mestranol https://global.dbpedia.org/id/549Ya |
| prov:wasDerivedFrom |
wikipedia-en:Mestranol?oldid=1123032923&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Ethinylestradiol.svg wiki-commons:Special:FilePath/Mestranol.svg wiki-commons:Special:FilePath/Mestranol_molecule_ball.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Mestranol |
| is dbo:wikiPageRedirects of |
dbr:Devocin dbr:Enovio dbr:Ovastol |
| is dbo:wikiPageWikiLink of |
dbr:Quinestrol dbr:Quingestrone dbr:List_of_compounds_with_carbon_number_21 dbr:List_of_estrogen_esters dbr:List_of_estrogens dbr:Mestranol/hydroxyprogesterone_acetate dbr:Mestranol/noretynodrel dbr:Methenmadinone_acetate dbr:Cunninghamella_elegans dbr:C21H26O2 dbr:List_of_progestogens_available_in_the_United_States dbr:Pentagestrone_acetate dbr:Combined_oral_contraceptive_pill dbr:Anagestone_acetate dbr:Megestrol_acetate dbr:Estrogen_(medication) dbr:Estrogen_ester dbr:George_Rosenkranz dbr:Lynestrenol dbr:California_Proposition_65_list_of_chemicals dbr:Chlormethenmadinone_acetate dbr:Combined_injectable_birth_control dbr:Frank_B._Colton dbr:Devocin dbr:Estradiol_(medication) dbr:Ethinylestradiol dbr:Ethynerone dbr:Etynodiol_diacetate dbr:Norethisterone dbr:Noretynodrel dbr:Enovio dbr:List_of_MeSH_codes_(D04) dbr:List_of_MeSH_codes_(D06) dbr:Hydroxyprogesterone_acetate dbr:Chlormadinone_acetate dbr:Chloroethynylnorgestrel dbr:Birth_control_pill_formulations dbr:High-dose_estrogen dbr:Tranel dbr:Ovastol dbr:Estrone_methyl_ether dbr:Sex_hormone-binding_globulin dbr:List_of_drugs:_Mep–Mes |
| is rdfs:seeAlso of |
dbr:Hydroxyprogesterone_acetate |
| is owl:differentFrom of |
dbr:Mestranol/noretynodrel dbr:Mestranol/norethisterone |
| is foaf:primaryTopic of |
wikipedia-en:Mestranol |
