Demethylase (original) (raw)
Demethylases are enzymes that remove methyl (CH3) groups from nucleic acids, proteins (particularly histones), and other molecules. Demethylases are important epigenetic proteins, as they are responsible for transcriptional regulation of the genome by controlling the methylation of DNA and histones, and by extension, the chromatin state at specific gene loci.
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| dbo:abstract | Demethylases are enzymes that remove methyl (CH3) groups from nucleic acids, proteins (particularly histones), and other molecules. Demethylases are important epigenetic proteins, as they are responsible for transcriptional regulation of the genome by controlling the methylation of DNA and histones, and by extension, the chromatin state at specific gene loci. (en) Demetilasi atau Demetilase atau Demetilate adalah proses kimia yang menghasilkan penghilangan Gugus metil (CH3) dari suatu molekul. Cara demetilasi yang paling umum ialah dengan cara penggantian gugus metil dengan atom hidrogen, yang mengakibatkan hilangnya satu karbon dan dua atom hidrogen. Dalam banyak hal demetilasi juga bersangkutan dengan Metilasi. (in) 탈메틸화효소(영어: demethylase) 또는 디메틸레이스는 핵산, 단백질(특히 히스톤) 및 기타 분자로부터 메틸기(CH3-)를 제거하는 반응을 촉매하는 효소이다. 탈메틸화효소는 후성유전자 변형 메커니즘에서 중요하다. 탈메틸화효소는 DNA와 히스톤 단백질에서 일어나는 메틸화의 수준을 조절하여 유전체의 전사 조절을 변경하고, 차례로 생물체 내의 특정 유전자 좌위에서 염색질의 상태를 조절한다. (ko) Demethylasen zijn enzymen die methylgroepen van proteïnen en andere stoffen kunnen onttrekken. Ze worden ingezet in verschillende biochemische processen, zoals bij chemotaxis (een vorm van signaaltransductie). Gemethyleerde lysineresiduen kunnen worden gedemethyleerd door oxidatie, waardoor formaldehyde ontstaat. De oxidatie grijpt plaats hetzij met behulp van zuurstof of flavine-adeninedinucleotide (FAD) als . Een goed voorbeeld van een demethylase en diens werking is de gefosforyleerde vorm van het , dat methylesters hydrolyseert tot onder andere methanol (daarom is het CheB-proteïne een methylesterase). Deze methylesters komen met name voor in het , een transmembraaneiwit in bacteriën dat in staat is om concentraties van bepaalde moleculen (veelal voedingsstoffen) te detecteren in de extracellulaire matrix, zodat de bacterie er vlot naartoe kan bewegen. Methylering en demethylering zorgt ervoor dat deze bewegingen goed gereguleerd worden. (nl) |
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| rdfs:comment | Demethylases are enzymes that remove methyl (CH3) groups from nucleic acids, proteins (particularly histones), and other molecules. Demethylases are important epigenetic proteins, as they are responsible for transcriptional regulation of the genome by controlling the methylation of DNA and histones, and by extension, the chromatin state at specific gene loci. (en) Demetilasi atau Demetilase atau Demetilate adalah proses kimia yang menghasilkan penghilangan Gugus metil (CH3) dari suatu molekul. Cara demetilasi yang paling umum ialah dengan cara penggantian gugus metil dengan atom hidrogen, yang mengakibatkan hilangnya satu karbon dan dua atom hidrogen. Dalam banyak hal demetilasi juga bersangkutan dengan Metilasi. (in) 탈메틸화효소(영어: demethylase) 또는 디메틸레이스는 핵산, 단백질(특히 히스톤) 및 기타 분자로부터 메틸기(CH3-)를 제거하는 반응을 촉매하는 효소이다. 탈메틸화효소는 후성유전자 변형 메커니즘에서 중요하다. 탈메틸화효소는 DNA와 히스톤 단백질에서 일어나는 메틸화의 수준을 조절하여 유전체의 전사 조절을 변경하고, 차례로 생물체 내의 특정 유전자 좌위에서 염색질의 상태를 조절한다. (ko) Demethylasen zijn enzymen die methylgroepen van proteïnen en andere stoffen kunnen onttrekken. Ze worden ingezet in verschillende biochemische processen, zoals bij chemotaxis (een vorm van signaaltransductie). Gemethyleerde lysineresiduen kunnen worden gedemethyleerd door oxidatie, waardoor formaldehyde ontstaat. De oxidatie grijpt plaats hetzij met behulp van zuurstof of flavine-adeninedinucleotide (FAD) als . (nl) |
| rdfs:label | Demethylase (en) Demetilasi (in) 탈메틸화효소 (ko) Demethylase (nl) |
| owl:sameAs | freebase:Demethylase wikidata:Demethylase http://bs.dbpedia.org/resource/Demetilaza dbpedia-id:Demethylase dbpedia-ko:Demethylase dbpedia-nl:Demethylase dbpedia-nn:Demethylase https://global.dbpedia.org/id/2PNiA |
| prov:wasDerivedFrom | wikipedia-en:Demethylase?oldid=1109491200&ns=0 |
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| is foaf:primaryTopic of | wikipedia-en:Demethylase |
