Disulfiram (original) (raw)
Disulfiram (INN), známý též pod svým obchodním názvem Antabus, je lék používaný v léčbě závislosti na alkoholu. Novější onkologický výzkum se věnuje jeho účinkům jako možného léku proti rakovině a připravuje se jeho testování při léčbě časných příznaků onemocnění covid-19.
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| dbo:abstract | El disulfiram és un fàrmac utilitzat per donar suport al tractament de l'alcoholisme, produint una aguda sensibilitat a l'alcohol. El nom comercial a l'estat espanyol és Antabus de Bohm, S.A. El disulfiram també s'està estudiant: * Com a tractament per la dependència de la cocaïna, ja que prevé la degradació de la dopamina (un neurotransmissor l'alliberament és estimulada per la cocaïna), l'excés de dopamina en els resultats d'augment de l'ansietat, la pressió arterial més alta, agitació i altres símptomes desagradables. * Per la seva activitat anti-protozoària. * Per a possible ús en la teràpia del càncer. (ca) Disulfiram (INN), známý též pod svým obchodním názvem Antabus, je lék používaný v léčbě závislosti na alkoholu. Novější onkologický výzkum se věnuje jeho účinkům jako možného léku proti rakovině a připravuje se jeho testování při léčbě časných příznaků onemocnění covid-19. (cs) الدِّيسلفيرام (ثُنائي السَّلفيرام) Disulfiram دواء لعلاج الإدمان الكحولي, وهو رادِعٌ لتَناول الكُحول alcohol deterrents، يَعمل كمُثبِّط لنازِعَة هيدروجينِ الأَلدَهيد [إِنزيم] aldehyde dehydrogenase inhibitor. (يباع تحت أسماء تجارية Antabuse و Antabus) هو دواء اكتشف في 1920وأفادت العديد من الدراسات أنه يحتوي على للنشاط، (ar) Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, causing many of the effects of a hangover to be felt immediately following alcohol consumption. Disulfiram plus alcohol, even small amounts, produces flushing, throbbing in the head and neck, a throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, fast heart rate, low blood pressure, fainting, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, abnormal heart rhythms, heart attack, acute congestive heart failure, unconsciousness, convulsions, and death. In the body, alcohol is converted to acetaldehyde, which is then broken down by acetaldehyde dehydrogenase. When the dehydrogenase enzyme is inhibited, acetaldehyde builds up, causing unpleasant side effects. Disulfiram should be used in conjunction with counseling and support. (en) Disulfiram (INN), auch Tetraethylthiuramdisulfid (TETD), (Handelsname Antabus®) ist ein Arzneistoff, der zur Unterstützung der Abstinenz bei Alkoholabhängigkeit angewendet werden kann. (de) Le disulfirame (nom de marque Espéral) ou bis(diéthylthiocarbamyl)disulfure ou disulfure de tétraéthyl-thiocarbamoyle a pour formule brute C10H20N2S4. C'est une poudre blanche, inodore et de saveur légèrement amère, fondant vers 71 °C. Le disulfirame est très soluble dans l'alcool et dans le chloroforme. Il est employé comme médicament dans le cas de dépendance à l'alcool car il inhibe une enzyme nécessaire à l'élimination de l'alcool, l'aldéhyde déshydrogénase, chargée de transformer l'acétaldéhyde en acide acétique. Des études cliniques, initiées en 2009, portent sur l'utilisation du disulfirame et son action sur la dopamine pour lutter contre la dépendance à la cocaïne. Un excès de dopamine augmente l'angoisse, engendre l'augmentation de la pression sanguine et des malaises. Par ailleurs, comme il contient du soufre, il donne mauvaise haleine. (fr) El disulfiram es un fármaco usado para ayudar en el tratamiento del alcoholismo crónico. Produce una reacción aguda y aversiva tras el consumo de etanol. Las marcas comerciales bajo las que se distribuye en diferentes países son Antabuse y Antabus, fabricados ambos por Odyssey Pharmaceuticals. Cuando se sigue un tratamiento con el fármaco, la ingesta de bebidas alcohólicas, incluso en pequeñas cantidades, provoca enrojecimiento, palpitaciones, cefalea intensa, náuseas, vómitos, sudoración, sed, disnea , hiperventilación, taquicardia, presión arterial baja, debilidad, vértigo, visión borrosa y confusión. El disulfiram no es una cura para el alcoholismo, ya que es más fácil dejar de tomar disulfiram que alcohol; si no se supervisa el tratamiento, el paciente alcohólico puede abandonarlo. Para algunos pacientes los rápidos y desagradables efectos no son suficientemente aversivos para superar la compulsión de tomar alcohol. (es) 디설피람(Disulfiram,상표명 안타뷰즈(Antabuse)가 있음)은 에탄올(음주 알코올)에 대한 급성 민감성을 생성하여 만성 알코올 중독 치료를 지원하는 데 사용되는 약물이다. 디설피람은 아세트알데히드 탈수소효소(acetaldehyde dehydrogenase)를 억제하여 알코올 소비 직후 숙취에 많은 영향을 느끼게 한다. (ko) ジスルフィラム（Disulfiram）とは抗酒癖剤。商品名はノックビン。欧米ではアンタビュース（Antabuse, Antabus）の名で市販されており、日本ではこちらの名称でも知られている。 (ja) Disulfiram – organiczny związek chemiczny, lek stosowany w leczeniu alkoholizmu, którego działanie polega na wpływie na metabolizm alkoholu etylowego. (pl) Il disulfiram (dietilditiocarbammato) è un farmaco usato nella cura dell'alcolismo.Il nome commerciale, in alcune nazioni, è Antabuse o Antabus o ancora Etiltox. (it) Disulfiram (thiuramdisulfide) is een ontwenningsmiddel dat wordt gebruikt bij de behandeling van alcoholisme. Het zorgt ervoor dat de patiënt na alcoholinname geconfronteerd wordt met onaangename effecten zoals braken, hoofdpijn, versnelde hartslag, hevige transpiratie en rood aanlopen. Men heeft het gevoel doodziek te zijn. De werking van het middel is gebaseerd op de angst voor de zeer onaangename effecten na de inname van alcohol. Voor patiënten met hartklachten zijn andere middelen beschikbaar omdat de hartslag zeer hoog kan oplopen bij het gebruik van disulfiram. Het voorschrijven van het middel is alleen zinvol als de verslaafde gemotiveerd is te stoppen met drinken en daarbij een extra steun in de rug wenst. Disulfiram is sinds 1948 internationaal op de markt. Het is op recept verkrijgbaar in tabletvorm onder de merknamen Antabus en Refusal. (nl) Disulfiram (strukturformel CCN (CC) C (=S) SSC (=S) N (CC) CC ) (även känt under produktnamnet Antabus) används som avvänjningsmedel i samband med alkoholmissbruk. (sv) Дисульфира́м (лат. Disulfiram) — лекарственный препарат, применяемый при лечении алкоголизма. (ru) Dissulfiram ou Dissulfiraão (variação em língua portuguesa) é um medicamento usado no tratamento do etilismo (alcoolismo). Foi a primeira intervenção farmacológica aprovada pelo FDA e é comercializado com os nomes Antabuse e Antabus. Para ser eficiente, deve ser associado a acompanhamento psicológico, farmacêutico e ocupacional. (pt) Дисульфіра́м (лат. Disulfiram) — лікарський препарат, застосовується при лікуванні хронічного алкоголізму, викликаючи гостру чутливість до етанолу. Дисульфірам діє, інгібуючи фермент ALDH2, що приводить до неприємних відчуттів похмілля відразу після вживання алкоголю. (uk) 双硫仑（英語：Disulfiram），商品名戒酒硫、安塔布司（Antabuse），是一種通过产生对乙醇（饮酒）的急性敏感性来用于支持治疗酒精成瘾的藥物。双硫仑的作用是抑制乙醛脱氢酶，导致饮酒后立即感受到宿醉的许多影响。即使是少量的酒精，也会产生脸红、头颈部跳动、跳动的头痛、呼吸困难、恶心、大量呕吐、出汗、口渴、胸痛、心悸、呼吸困难、换气过度、心跳过速、低血压、晕厥、明显的不安、虚弱、眩晕、视力模糊和意识模糊。在严重反应中，可能出现呼吸抑制、心血管衰竭、心律失常、心脏病发作、急性充血性心力衰竭、无意识、抽搐和死亡。 因為對酒精有立即性反應而被使用於治療慢性酒精依赖。在体内，酒精被转化为乙醛，然后被乙醛脱氢酶分解。当乙醛脱氢酶受到抑制时，乙醛就会积聚，引起令人不快的副作用，故应配合醫生處方使用。 已有研究表明，双硫仑可能用於治療癌症、寄生虫感染和潜伏的HIV感染。 (zh) |
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| rdfs:comment | Disulfiram (INN), známý též pod svým obchodním názvem Antabus, je lék používaný v léčbě závislosti na alkoholu. Novější onkologický výzkum se věnuje jeho účinkům jako možného léku proti rakovině a připravuje se jeho testování při léčbě časných příznaků onemocnění covid-19. (cs) الدِّيسلفيرام (ثُنائي السَّلفيرام) Disulfiram دواء لعلاج الإدمان الكحولي, وهو رادِعٌ لتَناول الكُحول alcohol deterrents، يَعمل كمُثبِّط لنازِعَة هيدروجينِ الأَلدَهيد [إِنزيم] aldehyde dehydrogenase inhibitor. (يباع تحت أسماء تجارية Antabuse و Antabus) هو دواء اكتشف في 1920وأفادت العديد من الدراسات أنه يحتوي على للنشاط، (ar) Disulfiram (INN), auch Tetraethylthiuramdisulfid (TETD), (Handelsname Antabus®) ist ein Arzneistoff, der zur Unterstützung der Abstinenz bei Alkoholabhängigkeit angewendet werden kann. (de) 디설피람(Disulfiram,상표명 안타뷰즈(Antabuse)가 있음)은 에탄올(음주 알코올)에 대한 급성 민감성을 생성하여 만성 알코올 중독 치료를 지원하는 데 사용되는 약물이다. 디설피람은 아세트알데히드 탈수소효소(acetaldehyde dehydrogenase)를 억제하여 알코올 소비 직후 숙취에 많은 영향을 느끼게 한다. (ko) ジスルフィラム（Disulfiram）とは抗酒癖剤。商品名はノックビン。欧米ではアンタビュース（Antabuse, Antabus）の名で市販されており、日本ではこちらの名称でも知られている。 (ja) Disulfiram – organiczny związek chemiczny, lek stosowany w leczeniu alkoholizmu, którego działanie polega na wpływie na metabolizm alkoholu etylowego. (pl) Il disulfiram (dietilditiocarbammato) è un farmaco usato nella cura dell'alcolismo.Il nome commerciale, in alcune nazioni, è Antabuse o Antabus o ancora Etiltox. (it) Disulfiram (strukturformel CCN (CC) C (=S) SSC (=S) N (CC) CC ) (även känt under produktnamnet Antabus) används som avvänjningsmedel i samband med alkoholmissbruk. (sv) Дисульфира́м (лат. Disulfiram) — лекарственный препарат, применяемый при лечении алкоголизма. (ru) Dissulfiram ou Dissulfiraão (variação em língua portuguesa) é um medicamento usado no tratamento do etilismo (alcoolismo). Foi a primeira intervenção farmacológica aprovada pelo FDA e é comercializado com os nomes Antabuse e Antabus. Para ser eficiente, deve ser associado a acompanhamento psicológico, farmacêutico e ocupacional. (pt) Дисульфіра́м (лат. Disulfiram) — лікарський препарат, застосовується при лікуванні хронічного алкоголізму, викликаючи гостру чутливість до етанолу. Дисульфірам діє, інгібуючи фермент ALDH2, що приводить до неприємних відчуттів похмілля відразу після вживання алкоголю. (uk) 双硫仑（英語：Disulfiram），商品名戒酒硫、安塔布司（Antabuse），是一種通过产生对乙醇（饮酒）的急性敏感性来用于支持治疗酒精成瘾的藥物。双硫仑的作用是抑制乙醛脱氢酶，导致饮酒后立即感受到宿醉的许多影响。即使是少量的酒精，也会产生脸红、头颈部跳动、跳动的头痛、呼吸困难、恶心、大量呕吐、出汗、口渴、胸痛、心悸、呼吸困难、换气过度、心跳过速、低血压、晕厥、明显的不安、虚弱、眩晕、视力模糊和意识模糊。在严重反应中，可能出现呼吸抑制、心血管衰竭、心律失常、心脏病发作、急性充血性心力衰竭、无意识、抽搐和死亡。 因為對酒精有立即性反應而被使用於治療慢性酒精依赖。在体内，酒精被转化为乙醛，然后被乙醛脱氢酶分解。当乙醛脱氢酶受到抑制时，乙醛就会积聚，引起令人不快的副作用，故应配合醫生處方使用。 已有研究表明，双硫仑可能用於治療癌症、寄生虫感染和潜伏的HIV感染。 (zh) El disulfiram és un fàrmac utilitzat per donar suport al tractament de l'alcoholisme, produint una aguda sensibilitat a l'alcohol. El nom comercial a l'estat espanyol és Antabus de Bohm, S.A. El disulfiram també s'està estudiant: (ca) Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, causing many of the effects of a hangover to be felt immediately following alcohol consumption. Disulfiram plus alcohol, even small amounts, produces flushing, throbbing in the head and neck, a throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, fast heart rate, low blood pressure, fainting, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, abnormal heart rhythms, heart attack, acute congestive (en) El disulfiram es un fármaco usado para ayudar en el tratamiento del alcoholismo crónico. Produce una reacción aguda y aversiva tras el consumo de etanol. Las marcas comerciales bajo las que se distribuye en diferentes países son Antabuse y Antabus, fabricados ambos por Odyssey Pharmaceuticals. (es) Le disulfirame (nom de marque Espéral) ou bis(diéthylthiocarbamyl)disulfure ou disulfure de tétraéthyl-thiocarbamoyle a pour formule brute C10H20N2S4. C'est une poudre blanche, inodore et de saveur légèrement amère, fondant vers 71 °C. Le disulfirame est très soluble dans l'alcool et dans le chloroforme. (fr) Disulfiram (thiuramdisulfide) is een ontwenningsmiddel dat wordt gebruikt bij de behandeling van alcoholisme. Het zorgt ervoor dat de patiënt na alcoholinname geconfronteerd wordt met onaangename effecten zoals braken, hoofdpijn, versnelde hartslag, hevige transpiratie en rood aanlopen. Men heeft het gevoel doodziek te zijn. De werking van het middel is gebaseerd op de angst voor de zeer onaangename effecten na de inname van alcohol. Voor patiënten met hartklachten zijn andere middelen beschikbaar omdat de hartslag zeer hoog kan oplopen bij het gebruik van disulfiram. Het voorschrijven van het middel is alleen zinvol als de verslaafde gemotiveerd is te stoppen met drinken en daarbij een extra steun in de rug wenst. (nl) |
| rdfs:label | Disulfiram (en) ديسلفيرام (ar) Disulfiram (ca) Disulfiram (cs) Disulfiram (de) Disulfiram (es) Disulfirame (fr) Disulfiram (it) 디설피람 (ko) ジスルフィラム (ja) Disulfiram (pl) Disulfiram (nl) Дисульфирам (ru) Dissulfiram (pt) Disulfiram (sv) Дисульфірам (uk) 双硫仑 (zh) |
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