E-box (original) (raw)

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An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues. Its specific DNA sequence, CANNTG (where N can be any nucleotide), with a palindromic canonical sequence of CACGTG, is recognized and bound by transcription factors to initiate gene transcription. Once the transcription factors bind to the promoters through the E-box, other enzymes can bind to the promoter and facilitate transcription from DNA to mRNA.

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dbo:abstract An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues. Its specific DNA sequence, CANNTG (where N can be any nucleotide), with a palindromic canonical sequence of CACGTG, is recognized and bound by transcription factors to initiate gene transcription. Once the transcription factors bind to the promoters through the E-box, other enzymes can bind to the promoter and facilitate transcription from DNA to mRNA. (en) Un elemento E-box es una secuencia de ADN que se localiza normalmente en la región promotora de un gen. La secuencia consenso de los elementos E-box es 5'-CANNTG-3', con una región palindrómica caracterizada por la secuencia 5'-CACGTG-3'.​Los factores de transcripción que se unen más comúnmente a estas secuencias E-box u otras semejantes son aquellos que presentan motivos hélice-bucle-hélice, los cuales, al unirse, activan la transcripción de los genes situados a continuación. (es) Е-бокс (Enhancer Box) — ДНК-последовательность, найденная в некоторых промоторных областях у эукариот, которые действует в качестве связывающего сайта белка и, как было установлено, регулируют экспрессию генов в нейронах, мышцах и других тканях. Спецификация такой ДНК-последовательности — CANNTG (где N может быть любой нуклеотид), с палиндромной . CACGTG распознаётся и связывается факторами транскрипции для инициации транскрипции генов. После того, как факторы транскрипции связываются с промоторами через E-бокс, другие ферменты могут связываться с промотором и облегчать транскрипцию мРНК из ДНК. (ru)
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rdfs:comment An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues. Its specific DNA sequence, CANNTG (where N can be any nucleotide), with a palindromic canonical sequence of CACGTG, is recognized and bound by transcription factors to initiate gene transcription. Once the transcription factors bind to the promoters through the E-box, other enzymes can bind to the promoter and facilitate transcription from DNA to mRNA. (en) Un elemento E-box es una secuencia de ADN que se localiza normalmente en la región promotora de un gen. La secuencia consenso de los elementos E-box es 5'-CANNTG-3', con una región palindrómica caracterizada por la secuencia 5'-CACGTG-3'.​Los factores de transcripción que se unen más comúnmente a estas secuencias E-box u otras semejantes son aquellos que presentan motivos hélice-bucle-hélice, los cuales, al unirse, activan la transcripción de los genes situados a continuación. (es) Е-бокс (Enhancer Box) — ДНК-последовательность, найденная в некоторых промоторных областях у эукариот, которые действует в качестве связывающего сайта белка и, как было установлено, регулируют экспрессию генов в нейронах, мышцах и других тканях. Спецификация такой ДНК-последовательности — CANNTG (где N может быть любой нуклеотид), с палиндромной . CACGTG распознаётся и связывается факторами транскрипции для инициации транскрипции генов. После того, как факторы транскрипции связываются с промоторами через E-бокс, другие ферменты могут связываться с промотором и облегчать транскрипцию мРНК из ДНК. (ru)
rdfs:label Secuencia E-box (es) E-box (en) Е-бокс (ru)
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