| dbo:abstract |
Giant-cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a subtype of undifferentiated lung cancer, traditionally classified within the non-small-cell lung carcinomas (NSCLC). The characteristic feature of this highly lethal malignancy is the distinctive light microscopic appearance of its extremely large cells, which are bizarre and highly pleomorphic, and which often contain more than one huge, misshapen, pleomorphic nucleus ("syncytia"), which result from cell fusion. Although it is common in the lung cancer literature to refer to histologically mixed tumors containing significant numbers of malignant giant cells as "giant-cell carcinomas", technically a diagnosis of "giant-cell carcinoma" should be limited strictly to neoplasms containing only malignant giant cells (i.e. "pure" giant-cell carcinoma). Aside from the great heterogeneity seen in lung cancers (especially those occurring among tobacco smokers), the considerable variability in diagnostic and sampling techniques used in medical practice, the high relative proportion of individuals with suspected GCCL who do not undergo complete surgical resection, and the near-universal lack of complete sectioning and pathological examination of resected tumor specimens prevent high levels of quantitative accuracy. (en) Le carcinome pulmonaire à cellules géantes est un sous-type de carcinome pulmonaire à grandes cellules (ou carcinome anaplasique à grandes cellules). (fr) |
| dbo:eMedicineSubject |
med (en) |
| dbo:icd10 |
- C33. C34. |
| dbo:icd9 |
162 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Giant_cell_carcinoma_-_Case_284_(13107156794).jpg?width=300 |
| dbo:wikiPageExternalLink |
http://www.iarc.fr/en/publications/pdfs-online/pat-gen/index.php http://www.cancer.gov/cancertopics/types/lung https://web.archive.org/web/20151115033702/http:/www.iarc.fr/en/publications/pdfs-online/pat-gen/index.php |
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| dbo:wikiPageWikiLink |
dbr:Cancer dbr:Carcinoid dbr:Carcinosarcoma dbr:Pulmonary_alveolus dbr:Sarcoma dbr:Electron_microscope dbr:Endoderm dbr:Epithelium dbr:Molecule dbr:Mortality_rate dbr:Non-small-cell_lung_carcinoma dbr:Neoplasm dbr:Prevalence dbc:Lung_cancer dbr:Biology dbr:Biopsy dbr:Cytopathology dbr:Cytoplasm dbr:Cytotrophoblast dbr:Bulla_(dermatology) dbr:United_States dbr:Carcinogenic dbr:Incidence_(epidemiology) dbr:Inflammation dbr:Intussusception_(medical_disorder) dbr:Small_intestine dbr:Light dbr:Estrogen dbr:Genome dbr:Emphysema dbr:Endocrine dbr:Giant_cell dbr:Glycolysis dbr:Bowel_obstruction dbr:Bronchioloalveolar_carcinoma dbr:Sarcomatoid_carcinoma_of_the_lung dbr:Lung_cancer dbr:Lymphoma dbr:Malignant dbr:Small-cell_carcinoma dbr:Stem_cell dbr:Clear-cell_adenocarcinoma dbr:Clinical_medicine dbr:Combined_small-cell_lung_carcinoma dbr:Embryo dbr:Lesion dbr:Metabolic_pathway dbr:Pathology dbr:Pleomorphism_(cytology) dbr:Surgery dbr:Mediastinum dbr:Adenocarcinoma_of_the_lung dbr:Adenosquamous_lung_carcinoma dbr:Adjuvant dbr:Cell_(biology) dbr:Adenocarcinoma dbr:Bronchiole dbr:Carcinoma dbr:Cell_fusion dbr:Cell_nucleus dbr:Chromatin dbr:Diagnosis dbr:Germ_cell_tumor dbr:Histiocyte dbr:Prognosis dbr:Radiation dbr:Segmental_resection dbr:Gynecomastia dbr:Heterogeneous dbr:Histology dbr:Surveillance_Epidemiology_and_End_Results dbr:Chemotherapy dbr:Choriocarcinoma dbr:Large-cell_lung_carcinoma dbr:Bleeding dbr:Tissue_(biology) dbr:Syncytiotrophoblast dbr:VEGF dbr:Phenotype dbr:Positron_emission_tomography dbr:Spindle_cell_carcinoma dbr:Pulmonary dbr:Microscope dbr:Oncogenesis dbr:World_Health_Organization dbr:Hilum_of_lung dbr:Lung dbr:Small-cell_lung_carcinoma dbr:Neoadjuvant_therapy dbr:Lymphocyte dbr:Salivary_gland–like_carcinoma_of_the_lung dbr:Giant-cell_tumor_of_bone dbr:Oncogene dbr:Syncytium dbr:X-ray_computed_tomography dbr:Cancer_treatment dbr:Neuroendocrine dbr:Squamous_cell_carcinoma dbr:Benign dbr:Anaplastic dbr:Cell_differentiation dbr:Pulmonary_blastoma dbr:Clear-cell_carcinoma dbr:Multipotent dbr:Pleomorphic_carcinoma |
| dbp:caption |
Pulmonary giant cell carcinoma represents a rare variety of non-small cell lung carcinoma that is characterized by the presence of numerous tumor giant cells and an influx of inflammatory cells that are mostly polymorphonuclear leukocytes admixed with macrophages. The dense oval aggregates of polymorphonuclear leukocytes seen in this image are probably located in the cytoplasm of tumor giant cells that have been sectioned in a plane that does not include their nuclei. (en) |
| dbp:date |
June 2018 (en) |
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med (en) |
| dbp:icd |
162 (xsd:integer) (en) - (en) C33. (en) C34. (en) |
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250 (xsd:integer) |
| dbp:name |
Giant cell carcinoma of the lung (en) |
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not using MEDMOS (en) |
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dbt:Citation_needed dbt:Cite_web dbt:Infobox_medical_condition_(new) dbt:Medical_resources dbt:Reflist dbt:MOS dbt:ICDO dbt:Respiratory_neoplasia |
| dcterms:subject |
dbc:Lung_cancer |
| gold:hypernym |
dbr:Form |
| rdf:type |
owl:Thing wikidata:Q12136 yago:Abstraction100002137 yago:Attribute100024264 yago:Condition113920835 yago:Disease114070360 yago:IllHealth114052046 yago:Illness114061805 yago:PathologicalState114051917 yago:PhysicalCondition114034177 dbo:Disease yago:State100024720 |
| rdfs:comment |
Le carcinome pulmonaire à cellules géantes est un sous-type de carcinome pulmonaire à grandes cellules (ou carcinome anaplasique à grandes cellules). (fr) Giant-cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a subtype of undifferentiated lung cancer, traditionally classified within the non-small-cell lung carcinomas (NSCLC). The characteristic feature of this highly lethal malignancy is the distinctive light microscopic appearance of its extremely large cells, which are bizarre and highly pleomorphic, and which often contain more than one huge, misshapen, pleomorphic nucleus ("syncytia"), which result from cell fusion. (en) |
| rdfs:label |
Giant-cell carcinoma of the lung (en) Carcinome pulmonaire à cellules géantes (fr) |
| owl:sameAs |
freebase:Giant-cell carcinoma of the lung wikidata:Giant-cell carcinoma of the lung dbpedia-fr:Giant-cell carcinoma of the lung http://uz.dbpedia.org/resource/O'pkaning_gigant_hujayrali_karsinomasi_(GCCL) https://global.dbpedia.org/id/4kA7o |
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wikipedia-en:Giant-cell_carcinoma_of_the_lung?oldid=1110143375&ns=0 |
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Giant cell carcinoma of the lung (en) |
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wikipedia-en:Giant-cell_carcinoma_of_the_lung |
