HSPA1L (original) (raw)
Heat shock 70 kDa protein 1L is a protein that in humans is encoded by the HSPA1L gene on chromosome 6. As a member of the heat shock protein 70 (Hsp70) family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. Its functions contribute to biological processes including signal transduction, apoptosis, protein homeostasis, and cell growth and differentiation. It has been associated with an extensive number of cancers, neurodegenerative diseases, cell senescence and aging, and Graft-versus-host disease.
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| dbo:abstract | Heat shock 70 kDa protein 1L is a protein that in humans is encoded by the HSPA1L gene on chromosome 6. As a member of the heat shock protein 70 (Hsp70) family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. Its functions contribute to biological processes including signal transduction, apoptosis, protein homeostasis, and cell growth and differentiation. It has been associated with an extensive number of cancers, neurodegenerative diseases, cell senescence and aging, and Graft-versus-host disease. (en) HSPA1L (англ. Heat shock protein family A (Hsp70) member 1 like) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 641 амінокислот, а молекулярна маса — 70 375. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Білок має сайт для зв'язування з АТФ, нуклеотидами. (uk) |
| dbo:wikiPageExternalLink | https://deepblue.lib.umich.edu/bitstream/2027.42/45535/1/11188_2005_Article_BF01534692.pdf |
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| dbo:wikiPageWikiLink | dbr:Cancer dbr:Cancers dbr:5'_UTR dbr:Protein-protein_interaction dbr:Parkinson’s_disease dbr:C-terminal dbr:Breast_cancer dbr:Allosteric_regulation dbr:Antigen dbr:Phagocytes dbr:Cytosol dbr:DNA dbr:Developmental_biology dbr:Inflammation dbr:Intron dbr:Gastric_cancer dbr:Gene dbr:Graft-versus-host_disease dbr:Mitochondria dbr:Physiological dbr:Apoptosis dbr:Alzheimer’s_disease dbr:Lung_cancer dbr:Major_histocompatibility_complex dbr:Malignancy dbr:Staurosporine dbr:Substrate_(biochemistry) dbr:HSPA1A dbr:HSPA1B dbr:Cytotoxic_T_cells dbr:Adenosine_triphosphate dbr:Amino_acid dbr:Doxorubicin dbr:Parkin_(ligase) dbr:Cell_growth dbr:Cell_nucleus dbr:Isoform dbr:Protein dbr:Hepatocellular_carcinoma dbr:Pathological dbr:CDNA dbr:Chaperone_protein dbr:Biomarker dbr:Co-chaperone dbr:Signal_transduction dbr:Translation_(biology) dbr:Mitosis dbc:Heat_shock_proteins dbr:Hsp70 dbr:Necrosis dbr:Organelle dbr:Caspase dbr:Neurodegenerative_disease dbr:Subcellular_localization dbr:Senescence dbr:Molecular_biology dbr:Colon_cancer dbr:Tumor_necrosis_factor-α dbr:Strokes dbr:Testis dbr:PARK2 dbr:Embryologic dbr:Embryonal dbr:Heart_attacks dbr:Huntington’s_disease dbr:N-terminal dbr:Prognostic dbr:Spinocerebellar_ataxias |
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| dct:subject | dbc:Heat_shock_proteins |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:WikicatHeatShockProteins dbo:HumanGene dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | Heat shock 70 kDa protein 1L is a protein that in humans is encoded by the HSPA1L gene on chromosome 6. As a member of the heat shock protein 70 (Hsp70) family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. Its functions contribute to biological processes including signal transduction, apoptosis, protein homeostasis, and cell growth and differentiation. It has been associated with an extensive number of cancers, neurodegenerative diseases, cell senescence and aging, and Graft-versus-host disease. (en) HSPA1L (англ. Heat shock protein family A (Hsp70) member 1 like) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 641 амінокислот, а молекулярна маса — 70 375. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Білок має сайт для зв'язування з АТФ, нуклеотидами. (uk) |
| rdfs:label | HSPA1L (en) HSPA1L (uk) |
| owl:sameAs | freebase:HSPA1L yago-res:HSPA1L wikidata:HSPA1L dbpedia-cy:HSPA1L dbpedia-uk:HSPA1L https://global.dbpedia.org/id/jaV6 |
| prov:wasDerivedFrom | wikipedia-en:HSPA1L?oldid=1095826131&ns=0 |
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| is foaf:primaryTopic of | wikipedia-en:HSPA1L |