| dbo:abstract |
let-7 ist eine regulatorische microRNA mit 21 Nukleotiden, die in dem Fadenwurm Caenorhabditis elegans (C. Elegans) entdeckt wurde. Der Name steht für „letal (tödlich) 7“. Mutationen im Gen für let-7 verursachen Störungen in der zeitlichen Entwicklung von C.elegans. Dabei werden wichtige Schritte ausgelassen oder mehrfach wiederholt. Der erwachsene Wurm ist im Ergebnis deformiert oder nicht lebensfähig (daher die Bezeichnung „letal“). Die let-7-RNA ist komplementär zu Elementen in der 3'-untranslatierten (3'-UTR) Region der Entwicklungsgene , lin-28, und und reguliert so deren Übersetzung (Translation, Proteinbiosynthese). Das Gen für let-7 ist offenbar evolutionär hochkonserviert und steuert die zeitliche Entwicklung vieler Tiergruppen, so neben Fadenwürmern Insekten, Weichtiere und Wirbeltiere. (de) The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about 70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference. (en) let-7是最早发现的两种microRNA之一（第一种是lin-4），发现于模式生物秀麗隱桿線蟲的基因组中，之后通过BLAST在果蝇和人类基因组中发现了同源物，形成了let-7非编码RNA家族。 (zh) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/RF00027-rscape.svg?width=300 |
| dbo:wikiPageExternalLink |
http://www.mirbase.org/cgi-bin/mirna_summary.pl%3Ffam=MIPF0000002 https://semanticscholar.org/paper/33da7580803c6e2dc0eb67116fbac7d5a9a2519a |
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dbr:Caenorhabditis_elegans dbr:BLAST dbr:MicroRNA dbr:Moulting dbr:Nucleotide dbr:MAP3K1 dbr:MYC dbr:Non-coding_RNAs dbc:MicroRNA dbr:Cyclin-dependent_kinase_5 dbr:Cyclin_A2 dbr:Cytokine dbr:CDC25A dbr:CDC34 dbr:E2F5 dbr:Induced_pluripotent_stem_cell dbr:Innate_immune_system dbr:RNA_interference dbr:P53 dbr:Post-transcriptional_regulation dbr:Intranasal dbr:Gene dbr:TLR4 dbr:Apoptosis dbr:Leiomyoma dbr:Lymphoma dbr:Macrophages dbr:Tumor_suppressor_gene dbr:Microarray dbr:Aurora_A_kinase dbr:Aurora_B_kinase dbr:Transgenic_mice dbr:Tumorigenesis dbr:Drosha dbr:HMGA2 dbr:Eukaryota dbr:Lipopolysaccharide dbr:Mir-48 dbr:Angiogenesis dbr:Cell_cycle_checkpoint dbr:Bcl2 dbr:Dicer dbr:Transcription_factor dbr:Ras_superfamily dbr:Stem-loop dbr:Cold-shock_domain dbr:Heterochrony dbr:Aurora_kinase dbr:Neonate dbr:Neuromuscular_junction dbr:Caspase_3 dbr:Sequence_conservation dbr:Loss_of_heterozygosity dbr:LIN28 dbr:Protozoa dbr:XPO5 dbr:Pasha_(protein) dbr:Untranslated_Region dbr:MicroRNAs dbr:Secondary_structure dbr:Adaptive_immunity dbr:CDK6 dbr:CDK8 dbr:T-cell |
| dbp:caption |
Predicted secondary structure and sequence conservation of let-7 (en) |
| dbp:id |
RF00027 (en) |
| dbp:mirbase |
MI0000001 (en) |
| dbp:mirbaseFamily |
MIPF0000002 (en) |
| dbp:name |
let-7 microRNA precursor (en) |
| dbp:rfam |
RF00027 (en) |
| dbp:rnaType |
dbr:MicroRNA dbr:Gene |
| dbp:symbol |
let-7 (en) |
| dbp:taxDomain |
dbr:Eukaryota |
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dbt:Cite_journal dbt:Reflist dbt:GO dbt:SO dbt:Infobox_rfam dbt:Rfam dbt:MiRNA_precursor_families |
| dct:subject |
dbc:MicroRNA |
| rdfs:comment |
let-7是最早发现的两种microRNA之一（第一种是lin-4），发现于模式生物秀麗隱桿線蟲的基因组中，之后通过BLAST在果蝇和人类基因组中发现了同源物，形成了let-7非编码RNA家族。 (zh) let-7 ist eine regulatorische microRNA mit 21 Nukleotiden, die in dem Fadenwurm Caenorhabditis elegans (C. Elegans) entdeckt wurde. Der Name steht für „letal (tödlich) 7“. Mutationen im Gen für let-7 verursachen Störungen in der zeitlichen Entwicklung von C.elegans. Dabei werden wichtige Schritte ausgelassen oder mehrfach wiederholt. Der erwachsene Wurm ist im Ergebnis deformiert oder nicht lebensfähig (daher die Bezeichnung „letal“). (de) The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about 70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demons (en) |
| rdfs:label |
Let-7 (de) Let-7 microRNA precursor (en) Let-7 (zh) |
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freebase:Let-7 microRNA precursor wikidata:Let-7 microRNA precursor dbpedia-de:Let-7 microRNA precursor dbpedia-zh:Let-7 microRNA precursor https://global.dbpedia.org/id/2dKrg |
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