Mambalgins (original) (raw)
Mambalgins are peptides found in the venom of the black mamba (Dendroaspis polylepis polylepis), an elapid snake. Mambalgins are members of the three-finger toxin (3FTx) protein family and have the characteristic three-finger protein fold. First reported by French researchers in 2012, mambalgins are unusual members of the 3FTx family in that they have the in vivo effect of causing analgesia without apparent toxicity. Their mechanism of action is potent inhibition of acid-sensing ion channels.
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| dbo:abstract | Mambalgins are peptides found in the venom of the black mamba (Dendroaspis polylepis polylepis), an elapid snake. Mambalgins are members of the three-finger toxin (3FTx) protein family and have the characteristic three-finger protein fold. First reported by French researchers in 2012, mambalgins are unusual members of the 3FTx family in that they have the in vivo effect of causing analgesia without apparent toxicity. Their mechanism of action is potent inhibition of acid-sensing ion channels. (en) Les mambalgines sont des fragments de protéines présents dans le venin du mamba. Elles y sont présentes à hauteur de 0,5 %. Il existe deux mambalgines différentes, la mambalgine-1 et la mambalgine-2. Elles ont été découvertes par Eric Lingueglia et son équipe, car ils cherchaient un venin agissant sur les canaux ioniques ASICs. Les mambalgines sont à l'étude par la société Theralpha pour l'élaboration d'un nouvel analgésique. (fr) Mambalginy – peptydy występujące w jadzie mamby czarnej (Dendroaspis polylepis polylepis), opisane w 2012. Należą do rodziny białek toksyn trójpalczastych (3FTx) i mają charakterystyczną formę trzech pętli – palców (fingers). (pl) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Mambalgin.png?width=300 |
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| dbo:wikiPageWikiLink | dbr:Predator dbr:Membrane_protein dbr:Black_mamba dbr:Beta_sheet dbr:Peptides dbr:Pharmaceutical_drug dbr:In_vivo dbr:Psalmopoeus_cambridgei dbr:Elapidae dbr:Snake dbr:Snake_venom dbr:Pain dbr:Three-finger_protein dbr:Three-finger_toxin dbr:Toxic dbr:Ion_channel dbr:Analgesia dbr:Eastern_green_mamba dbr:PH dbr:Central_nervous_system dbr:Protein_family dbr:Prey dbr:Tarantula dbr:Laboratory_mice dbr:Acid-sensing_ion_channel dbc:Vertebrate_toxins dbr:Tertiary_structure dbr:Disulfide_bond dbr:Disulphide_bond dbr:Anthopleura_elegantissima dbr:Opioid dbr:Sea_anemone dbr:X-ray_crystallography dbr:Mechanism_of_action dbr:Sensory_neuron dbr:Side_effect dbr:Nicotinic_acetylcholine_receptor dbr:Electrostatic_potential dbr:Amino_acid_residue dbr:Micrurus_tener_tener dbr:Respiratory_depression dbr:PcTx1 dbr:Sequence_similarity dbr:Multimer dbr:APETx2 dbr:File:Esquema_mambalgina.jpg dbr:MitTx |
| dbp:caption | The structure of mambalgin-1, showing the three "finger" loops in red , blue , and green , with core disulfide bonds highlighted in yellow. (en) |
| dbp:name | Mambalgin-1 (en) Mambalgin-2 (en) Mambalgin-3 (en) |
| dbp:organism | Dendroaspis polylepis polylepis (en) Dendroaspis angusticeps (en) |
| dbp:pdb | 2 (xsd:integer) 5 (xsd:integer) |
| dbp:uniprot | C0HJB0 (en) P0DKR6 (en) P0DKS3 (en) |
| dbp:wikiPageUsesTemplate | dbt:Commonscatinline dbt:Infobox_nonhuman_protein dbt:Reflist |
| dct:subject | dbc:Vertebrate_toxins |
| gold:hypernym | dbr:Peptides |
| rdf:type | yago:WikicatVertebrateToxins yago:Matter100020827 yago:PhysicalEntity100001930 yago:Poison115032376 dbo:Protein yago:Substance100020090 yago:Toxin115034074 |
| rdfs:comment | Mambalgins are peptides found in the venom of the black mamba (Dendroaspis polylepis polylepis), an elapid snake. Mambalgins are members of the three-finger toxin (3FTx) protein family and have the characteristic three-finger protein fold. First reported by French researchers in 2012, mambalgins are unusual members of the 3FTx family in that they have the in vivo effect of causing analgesia without apparent toxicity. Their mechanism of action is potent inhibition of acid-sensing ion channels. (en) Les mambalgines sont des fragments de protéines présents dans le venin du mamba. Elles y sont présentes à hauteur de 0,5 %. Il existe deux mambalgines différentes, la mambalgine-1 et la mambalgine-2. Elles ont été découvertes par Eric Lingueglia et son équipe, car ils cherchaient un venin agissant sur les canaux ioniques ASICs. Les mambalgines sont à l'étude par la société Theralpha pour l'élaboration d'un nouvel analgésique. (fr) Mambalginy – peptydy występujące w jadzie mamby czarnej (Dendroaspis polylepis polylepis), opisane w 2012. Należą do rodziny białek toksyn trójpalczastych (3FTx) i mają charakterystyczną formę trzech pętli – palców (fingers). (pl) |
| rdfs:label | Mambalgine (fr) Mambalgins (en) Mambalginy (pl) |
| owl:sameAs | freebase:Mambalgins yago-res:Mambalgins wikidata:Mambalgins dbpedia-fr:Mambalgins dbpedia-pl:Mambalgins https://global.dbpedia.org/id/33Lsb |
| prov:wasDerivedFrom | wikipedia-en:Mambalgins?oldid=1048127600&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Esquema_mambalgina.jpg wiki-commons:Special:FilePath/Mambalgin.png |
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