PPIF (original) (raw)
Peptidyl-prolyl cis-trans isomerase, mitochondrial (PPIF) is an enzyme that in humans is encoded by the PPIF gene. It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. PPIF is a major component of the mitochondrial permeability transition pore (MPTP) and, thus, highly involved in mitochondrial metabolism and apoptosis, as well as in mitochondrial diseases and related conditions, including cardiac diseases, neurodegenerative diseases, and muscular dystrophy. In addition, PPIF participates in inflammation, as
| Property | Value |
|---|---|
| dbo:abstract | Peptidyl-prolyl cis-trans isomerase, mitochondrial (PPIF) is an enzyme that in humans is encoded by the PPIF gene. It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. PPIF is a major component of the mitochondrial permeability transition pore (MPTP) and, thus, highly involved in mitochondrial metabolism and apoptosis, as well as in mitochondrial diseases and related conditions, including cardiac diseases, neurodegenerative diseases, and muscular dystrophy. In addition, PPIF participates in inflammation, as well as in ischemic reperfusion injury, AIDS, and cancer. (en) PPIF (англ. Peptidylprolyl isomerase F) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми. Довжина поліпептидного ланцюга білка становить 207 амінокислот, а молекулярна маса — 22 040. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до ізомераз, . Задіяний у таких біологічних процесах, як апоптоз, ацетилювання, альтернативний сплайсинг. Локалізований у мітохондрії. (uk) |
| dbo:wikiPageID | 15067149 (xsd:integer) |
| dbo:wikiPageLength | 13214 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1116601655 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Cancer dbr:Proline dbr:Protein-protein_interaction dbr:Parkinson’s_disease dbr:Peptidylprolyl_isomerase_D dbr:Depolarization dbr:Inflammation dbr:Inner_mitochondrial_membrane dbr:Oligopeptide dbr:Enzyme dbr:Gene dbr:Apoptosis dbr:Alzheimer’s_disease dbr:Traumatic_brain_injury dbr:Glaucoma dbr:Cyclosporin_A dbr:Cytochrome_C dbr:AIDS dbr:Adenine_nucleotide_translocator dbr:Adenosine_triphosphate dbr:Cyclophilin dbr:Isomerization dbr:Protein_folding dbr:Diabetic_retinopathy dbr:Dilated_cardiomyopathy dbr:Metabolism dbr:Caspase dbr:Mitochondrial_permeability_transition_pore dbr:Muscular_dystrophy dbr:Reactive_oxygen_species dbr:FKBP dbr:Parvulin dbr:Prolyl_isomerase dbr:Peptide_bond dbr:Α-helices dbr:Β-barrel dbr:Cis-trans dbr:CsA dbr:Ischemic_reperfusion_injury |
| dbp:wikiPageUsesTemplate | dbt:UCSC_genome_browser dbt:Cite_journal dbt:For dbt:Infobox_gene dbt:PDB_Gallery dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:UCSC_gene_details |
| gold:hypernym | dbr:Enzyme |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 dbo:HumanGene dbo:Protein |
| rdfs:comment | Peptidyl-prolyl cis-trans isomerase, mitochondrial (PPIF) is an enzyme that in humans is encoded by the PPIF gene. It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. PPIF is a major component of the mitochondrial permeability transition pore (MPTP) and, thus, highly involved in mitochondrial metabolism and apoptosis, as well as in mitochondrial diseases and related conditions, including cardiac diseases, neurodegenerative diseases, and muscular dystrophy. In addition, PPIF participates in inflammation, as (en) PPIF (англ. Peptidylprolyl isomerase F) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми. Довжина поліпептидного ланцюга білка становить 207 амінокислот, а молекулярна маса — 22 040. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | PPIF (en) PPIF (uk) |
| owl:sameAs | freebase:PPIF http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/2554 wikidata:PPIF dbpedia-cy:PPIF http://tt.dbpedia.org/resource/PPIF dbpedia-uk:PPIF https://global.dbpedia.org/id/joXb |
| prov:wasDerivedFrom | wikipedia-en:PPIF?oldid=1116601655&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:PPIF |
| is dbo:wikiPageRedirects of | dbr:PPIF_(gene) |
| is dbo:wikiPageWikiLink of | dbr:Housekeeping_gene dbr:Peptidylprolyl_isomerase_D dbr:List_of_human_protein-coding_genes_3 dbr:Cyclophilin dbr:Phosphate_carrier_protein,_mitochondrial dbr:PPIF_(gene) |
| is foaf:primaryTopic of | wikipedia-en:PPIF |