Mitochondrial permeability transition pore (original) (raw)
The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of the mitochondria under certain pathological conditions such as traumatic brain injury and stroke. Opening allows increase in the permeability of the mitochondrial membranes to molecules of less than 1500 Daltons in molecular weight. Induction of the permeability transition pore, mitochondrial membrane permeability transition (mPT or MPT), can lead to mitochondrial swelling and cell death through apoptosis or necrosis depending on the particular biological setting.
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| dbo:abstract | La transición de permeabilidad mitocondrial, (PTPm) se refiere al incremento en la permeabilidad de la membrana interna mitocondrial a iones y metabolitos cuya masa molecular no exceda los 1.5 kDa. La PTPm es el resultado de la apertura de poros de la transición de la permeabilidad mitocondrial, que son poros proteicos que se formaron en las membranas de las mitocondrias bajo ciertas condiciones patológicas, tales como lesión cerebral traumática y accidentes cerebrovasculares. La inducción del poro de transición de la permeabilidad puede provocar inflamación mitocondrial y muerte celular y desempeña un papel importante en algunos tipos de apoptosis. La PTPm fue propuesta por Haworth y Hunter en 1979 y desde entonces se ha encontrado implicada en degeneración celular, tales como la neurodegeneración, un proceso que da lugar a daños y muerte de las neuronas. La PTPm se estudia con frecuencia en las células del hígado, que tienen una cantidad especialmente elevada de mitocondrias. (es) The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of the mitochondria under certain pathological conditions such as traumatic brain injury and stroke. Opening allows increase in the permeability of the mitochondrial membranes to molecules of less than 1500 Daltons in molecular weight. Induction of the permeability transition pore, mitochondrial membrane permeability transition (mPT or MPT), can lead to mitochondrial swelling and cell death through apoptosis or necrosis depending on the particular biological setting. (en) 미토콘드리아의 투과성 전환 포어(mPTP 또는 MPTP; PTP, mTP 또는 MTP라고도 함)는 특정 병리학적 조건 하에서 미토콘드리아 내막에 형성되는 단백질이다. 개구부는 미토콘드리아막의 투과성을 분자량에서 1500 Dalton 미만의 분자로 증가시킬 수 있다. 침투성 전환 공극의 유도, 미토콘드리아막 투과성 전환(mPT 또는 MPT)은 특정 생물학적 환경에 따라 미토콘드리아 부기와 세포 사멸을 초래할 수 있다. (ko) |
| dbo:wikiPageExternalLink | http://www.celldeath.de/encyclo/misc/pt.htm https://www.researchgate.net/publication/272153136_Mitochondrial_permeability_transition_pore_an_enigmatic_gatekeeper |
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| rdfs:comment | The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of the mitochondria under certain pathological conditions such as traumatic brain injury and stroke. Opening allows increase in the permeability of the mitochondrial membranes to molecules of less than 1500 Daltons in molecular weight. Induction of the permeability transition pore, mitochondrial membrane permeability transition (mPT or MPT), can lead to mitochondrial swelling and cell death through apoptosis or necrosis depending on the particular biological setting. (en) 미토콘드리아의 투과성 전환 포어(mPTP 또는 MPTP; PTP, mTP 또는 MTP라고도 함)는 특정 병리학적 조건 하에서 미토콘드리아 내막에 형성되는 단백질이다. 개구부는 미토콘드리아막의 투과성을 분자량에서 1500 Dalton 미만의 분자로 증가시킬 수 있다. 침투성 전환 공극의 유도, 미토콘드리아막 투과성 전환(mPT 또는 MPT)은 특정 생물학적 환경에 따라 미토콘드리아 부기와 세포 사멸을 초래할 수 있다. (ko) La transición de permeabilidad mitocondrial, (PTPm) se refiere al incremento en la permeabilidad de la membrana interna mitocondrial a iones y metabolitos cuya masa molecular no exceda los 1.5 kDa. La PTPm es el resultado de la apertura de poros de la transición de la permeabilidad mitocondrial, que son poros proteicos que se formaron en las membranas de las mitocondrias bajo ciertas condiciones patológicas, tales como lesión cerebral traumática y accidentes cerebrovasculares. La inducción del poro de transición de la permeabilidad puede provocar inflamación mitocondrial y muerte celular y desempeña un papel importante en algunos tipos de apoptosis. (es) |
| rdfs:label | Transición de la permeabilidad mitocondrial (es) 미토콘드리아 투과성 변이공 (ko) Mitochondrial permeability transition pore (en) |
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