PRDX5 (original) (raw)
Peroxiredoxin-5 (PRDX5), mitochondrial is a protein that in humans is encoded by the PRDX5 gene, located on chromosome 11. This gene encodes a member of the six-member peroxiredoxin family of antioxidant enzymes. Like the other five members, PRDX5 is widely expressed in tissues but differs by its large subcellular distribution. In human cells, it has been shown that PRDX5 can be localized to mitochondria, peroxisomes, the cytosol, and the nucleus. Human PRDX5 is identified by virtue of the sequence homologies to yeast peroxisomal antioxidant enzyme PMP20.
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| dbo:abstract | Peroxiredoxin-5 (PRDX5), mitochondrial is a protein that in humans is encoded by the PRDX5 gene, located on chromosome 11. This gene encodes a member of the six-member peroxiredoxin family of antioxidant enzymes. Like the other five members, PRDX5 is widely expressed in tissues but differs by its large subcellular distribution. In human cells, it has been shown that PRDX5 can be localized to mitochondria, peroxisomes, the cytosol, and the nucleus. Human PRDX5 is identified by virtue of the sequence homologies to yeast peroxisomal antioxidant enzyme PMP20. Biochemically, PRDX5 is a peroxidase that can use cytosolic or mitochondrial thioredoxins to reduce alkyl hydroperoxides or peroxynitrite with high rate constants in the 106 to 107 M−1s−1 range, whereas its reaction with hydrogen peroxide is more modest, in the 105 M−1s−1 range. So far, PRDX5 has been shown to be a cytoprotective antioxidant enzyme that inhibits endogenous or exogenous peroxide accumulation. (en) Пероксиредоксин-5 (англ. Peroxiredoxin 5) – білок, який кодується геном PRDX5, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 214 амінокислот, а молекулярна маса — 22 086. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Цей білок за функціями належить до оксидоредуктаз, антиоксидантів, . Локалізований у цитоплазмі, мітохондрії, пероксисомах. (uk) |
| dbo:wikiPageExternalLink | http://orbi.ulg.ac.be/handle/2268/59241 http://orbi.ulg.ac.be/handle/2268/64083 |
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| dbo:wikiPageWikiLink | dbr:Sarcoidosis dbr:Breast_cancer dbr:Antioxidant dbr:Peroxide dbr:Peroxynitrite dbr:Cytosol dbr:Inflammation dbr:P53 dbr:Gene dbr:Mitochondrion dbr:Apoptosis dbr:MPP+ dbr:Chinese_hamster_ovary_cell dbr:Stroke dbr:Peroxiredoxin dbr:Thioredoxin dbr:GATA1 dbr:HeLa dbr:Alpha_helix dbr:3T3_cells dbr:Doxorubicin dbr:Etoposide dbr:Cell_nucleus dbr:Protein_dimer dbr:Protein dbr:Astrocyte dbr:TNF-alpha dbr:Organic_peroxide dbr:Platelet-derived_growth_factor dbr:Mouse_brain dbr:Peroxisome dbr:Multiple_sclerosis_lesions |
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| gold:hypernym | dbr:Protein |
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| rdfs:comment | Peroxiredoxin-5 (PRDX5), mitochondrial is a protein that in humans is encoded by the PRDX5 gene, located on chromosome 11. This gene encodes a member of the six-member peroxiredoxin family of antioxidant enzymes. Like the other five members, PRDX5 is widely expressed in tissues but differs by its large subcellular distribution. In human cells, it has been shown that PRDX5 can be localized to mitochondria, peroxisomes, the cytosol, and the nucleus. Human PRDX5 is identified by virtue of the sequence homologies to yeast peroxisomal antioxidant enzyme PMP20. (en) Пероксиредоксин-5 (англ. Peroxiredoxin 5) – білок, який кодується геном PRDX5, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 214 амінокислот, а молекулярна маса — 22 086. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | PRDX5 (en) Пероксиредоксин-5 (uk) |
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