PSMB6 (original) (raw)
Proteasome subunit beta type-6 also known as 20S proteasome subunit beta-1 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB6 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-6, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Caspase-like" activity and is capable of cleaving after acidic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purp
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| dbo:abstract | Proteasome subunit beta type-6 also known as 20S proteasome subunit beta-1 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB6 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-6, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Caspase-like" activity and is capable of cleaving after acidic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. (en) PSMB6 (англ. Proteasome subunit beta 6) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 239 амінокислот, а молекулярна маса — 25 358. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до гідролаз, протеаз, , фосфопротеїнів. Задіяний у таких біологічних процесах, як взаємодія хазяїн-вірус, ацетилювання. Локалізований у цитоплазмі, ядрі. (uk) |
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| dbo:wikiPageWikiLink | dbr:Prostaglandins dbr:Proteasome dbr:Pulmonary_hypertension dbr:Androgen_receptors dbr:C-Myc dbr:Dementia dbr:Huntington's_disease dbr:Retinoblastoma dbr:Rheumatoid_arthritis dbr:Cyclin-dependent_kinase dbr:C-Jun dbr:Interleukin_8 dbr:P53 dbr:Creutzfeldt–Jakob_disease dbr:PSMB10 dbr:ICAM-1 dbr:Proteolysis dbr:Gene dbr:NF-κB dbr:Myc dbr:PSMB1 dbr:Apoptosis dbr:Lung_cancer dbr:Sjögren_syndrome dbr:Pick's_disease dbr:STRING dbr:C-Fos dbr:Adenomatous_polyposis_coli dbr:Transcription_factors dbr:Heart_failure dbr:ALS dbr:Amyotrophic_lateral_sclerosis dbr:Cytokines dbr:Alzheimer's_disease dbr:Abl_(gene) dbr:Nitric_oxide dbr:Parkinson's_disease dbr:Cell_cycle dbr:Cell_growth dbr:Protein_folding dbr:Protein dbr:Raf_kinase dbr:PSMB8 dbr:STAT3 dbr:Smooth_muscle dbr:A549_cell dbr:Systemic_lupus_erythematosus dbr:PSMB9 dbr:Autoimmune_disease dbr:Src_(gene) dbr:MOS_(gene) dbr:MYB_(gene) dbr:Western_blot dbr:VCAM-1 dbr:Exon dbr:PSMB2 dbr:Ischemic dbr:Ventricular_hypertrophy dbr:P-selectin dbr:PSMB5 dbr:Von_Hippel-Lindau_tumor_suppressor dbr:Muscular_dystrophies dbr:Proto-oncogenes dbr:Ubiquitination dbr:2-DE dbr:Adhesion_molecules dbr:Immunoblot dbr:Malignancies dbr:N-terminal dbr:MS/MS dbr:TNF-α |
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| rdfs:comment | Proteasome subunit beta type-6 also known as 20S proteasome subunit beta-1 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB6 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-6, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Caspase-like" activity and is capable of cleaving after acidic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purp (en) PSMB6 (англ. Proteasome subunit beta 6) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 239 амінокислот, а молекулярна маса — 25 358. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | PSMB6 (en) PSMB6 (uk) |
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