PSMB9 (original) (raw)
Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Trypsin-like" activity and is capable of cleaving after basic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein compone
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dbo:abstract | Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Trypsin-like" activity and is capable of cleaving after basic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. The constitutive subunit beta1, beta2, and beta 5 (systematic nomenclature) can be replaced by their inducible counterparts beta1i, 2i, and 5i when cells are under the treatment of interferon-γ. The resulting proteasome complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous MHC class-I restricted T cell epitopes. (en) PSMB9 (англ. Proteasome subunit beta 9) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 219 амінокислот, а молекулярна маса — 23 264. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до гідролаз, протеаз, . Задіяний у таких біологічних процесах, як імунітет, взаємодія хазяїн-вірус, ацетилювання, альтернативний сплайсинг. Локалізований у цитоплазмі, ядрі. (uk) |
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dbo:wikiPageWikiLink | dbr:Carcinomas dbr:Prostaglandins dbr:Proteasome dbr:Methylation dbr:Androgen_receptors dbr:C-Myc dbr:Dementia dbr:Huntington's_disease dbr:Beta-2_microglobulin dbr:Retinoblastoma dbr:Rheumatoid_arthritis dbr:Cyclin-dependent_kinase dbr:Vaccines dbr:Interleukin_8 dbr:P53 dbr:Creutzfeldt–Jakob_disease dbr:SELL dbr:OAS1 dbr:PSMB10 dbr:ICAM-1 dbr:MAGED1 dbr:Proteolysis dbr:Gene dbr:NF-κB dbr:Myc dbr:PSMB1 dbr:Apoptosis dbr:Major_histocompatibility_complex dbr:Sjögren_syndrome dbr:Pick's_disease dbr:C-Fos dbr:C-jun dbr:Adenomatous_polyposis_coli dbr:Transcription_factors dbr:HLA-DMA dbr:HLA-DOA dbr:HLA-DQB1 dbr:Heart_failure dbr:Adenosine_triphosphate dbr:Amyotrophic_lateral_sclerosis dbr:Cytokines dbr:Alzheimer's_disease dbr:Abl_(gene) dbr:Nitric_oxide dbr:Parkinson's_disease dbr:Cell_cycle dbr:Cell_growth dbr:Epithelial dbr:Protein dbr:Raf_kinase dbr:PSMB8 dbr:STAT3 dbr:PRDX4 dbr:Systemic_lupus_erythematosus dbr:TAP2 dbr:Autoimmune_disease dbr:CD53 dbr:Src_(gene) dbr:HLA-DQB2 dbr:IFIT1 dbr:IFIT2 dbr:IFIT3 dbr:Influenza dbr:Oncology dbr:Complement_factor_D dbr:HERC5 dbr:MOS_(gene) dbr:MYB_(gene) dbr:Ubiquitin dbr:TAP1 dbr:VCAM-1 dbr:FCGR3B dbr:Von_Hippel–Lindau_tumor_suppressor dbr:Infectious_diseases dbr:Dengue dbr:PSMB2 dbr:STAT1 dbr:Lysosomal dbr:Ischemic dbr:Ventricular_hypertrophy dbr:Serous dbr:P-selectin dbr:PTPRC dbr:MX1 dbr:PSMB5 dbr:Muscular_dystrophies dbr:Proto-oncogenes dbr:Ubiquitination dbr:Ubiquitin–proteasome_system dbr:HLA-DQA1 dbr:Gamma_interferon dbr:Adhesion_molecules dbr:Malignancies dbr:N-terminal dbr:Ovarian dbr:TNF-α |
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rdfs:comment | Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Trypsin-like" activity and is capable of cleaving after basic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein compone (en) PSMB9 (англ. Proteasome subunit beta 9) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 219 амінокислот, а молекулярна маса — 23 264. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
rdfs:label | PSMB9 (en) PSMB9 (uk) |
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is dbo:wikiPageWikiLink of | dbr:List_of_human_protein-coding_genes_3 dbr:PSMB10 dbr:PSMB6 dbr:PSMB1 dbr:CANDLE_syndrome dbr:PSMB8 dbr:Immunoproteasome dbr:PSMB9_(gene) dbr:PSMB5 |
is foaf:primaryTopic of | wikipedia-en:PSMB9 |