PYGL (original) (raw)
Glycogen phosphorylase, liver form (PYGL), also known as human liver glycogen phosphorylase (HLGP), is an enzyme that in humans is encoded by the PYGL gene on chromosome 14. This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 14. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozy
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| dbo:abstract | Glycogen phosphorylase, liver form (PYGL), also known as human liver glycogen phosphorylase (HLGP), is an enzyme that in humans is encoded by the PYGL gene on chromosome 14. This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 14. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms [provided by RefSeq, Feb 2011]. (en) PYGL (англ. Glycogen phosphorylase L) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми. Довжина поліпептидного ланцюга білка становить 847 амінокислот, а молекулярна маса — 97 149. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до трансфераз, глікозилтрансфераз, фосфопротеїнів. Задіяний у таких біологічних процесах, як вуглеводний обмін, метаболізм глікогену, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з нуклеотидами, піридоксаль-фосфатом. (uk) |
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| dbo:wikiPageWikiLink | dbr:Calcium dbr:Product_(biology) dbr:Purine dbr:Pyridoxal_phosphate dbr:Muscle dbr:Monomer dbr:C-terminal dbr:Homeostasis dbr:Hormonal dbr:Hypoglycemia dbr:Cytosol dbr:Isozymes dbc:Enzymes dbr:Enzyme dbr:Gene dbr:Glucose dbr:Glucose_1-phosphate dbr:Glycogen_storage_disease_type_VI dbr:Glycolysis dbr:Brain dbr:Liver dbr:Substrate_(biochemistry) dbr:Active_site dbr:Catalyse dbr:Adenine dbr:Allosteric dbr:Amino_acid dbr:Alternative_splicing dbr:Biosynthetic dbr:Glycemic dbr:Glycogen dbr:Glycogen_phosphorylase dbr:Isozyme dbr:Isoform dbr:Covalent_bond dbr:Ketosis dbr:Cofactor_(biochemistry) dbr:Hepatomegaly dbr:Diabetes dbr:Metabolism dbr:Schiff_base dbr:Subcellular_localization dbr:Phosphorylase_kinase dbr:Phosphorolysis dbr:Phosphorylation dbr:PYGB dbr:PP1 dbr:Glucose-1-phosphate dbr:N-terminal dbr:Homodimer |
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| gold:hypernym | dbr:Enzyme |
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| rdfs:comment | Glycogen phosphorylase, liver form (PYGL), also known as human liver glycogen phosphorylase (HLGP), is an enzyme that in humans is encoded by the PYGL gene on chromosome 14. This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 14. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozy (en) PYGL (англ. Glycogen phosphorylase L) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми. Довжина поліпептидного ланцюга білка становить 847 амінокислот, а молекулярна маса — 97 149. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | PYGL (en) PYGL (uk) |
| owl:sameAs | yago-res:PYGL wikidata:PYGL http://tt.dbpedia.org/resource/PYGL dbpedia-uk:PYGL https://global.dbpedia.org/id/jvEZ |
| prov:wasDerivedFrom | wikipedia-en:PYGL?oldid=1043972324&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:PYGL |
| is dbo:wikiPageWikiLink of | dbr:List_of_human_protein-coding_genes_3 dbr:Myophosphorylase dbr:Glycogen_storage_disease dbr:Inborn_errors_of_carbohydrate_metabolism dbr:PYGB |
| is foaf:primaryTopic of | wikipedia-en:PYGL |