Romidepsin (original) (raw)
Romidepsin, also known as Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs). Romidepsin is a natural product obtained from the bacterium Chromobacterium violaceum, and works by blocking enzymes known as histone deacetylases, thus inducing apoptosis. It is sometimes referred to as depsipeptide, after the class of molecules to which it belongs. Romidepsin is branded and owned by Gloucester Pharmaceuticals, now a part of Celgene.
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| dbo:abstract | Romidepsin, also known as Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs). Romidepsin is a natural product obtained from the bacterium Chromobacterium violaceum, and works by blocking enzymes known as histone deacetylases, thus inducing apoptosis. It is sometimes referred to as depsipeptide, after the class of molecules to which it belongs. Romidepsin is branded and owned by Gloucester Pharmaceuticals, now a part of Celgene. (en) ロミデプシン（INN: romidepsin）とは、（CTCL）ならびにその他の（PTCLs）に使用される抗がん剤である。商品名はIstodax。ロミデプシンは細菌から得られる天然物であり、ヒストン脱アセチル化酵素の働きを妨げることによって、細胞にアポトーシスを誘導する。また、属する化合物群に因んで「デプシペプチド」と呼ばれることもある。ロミデプシンはグロスター・ファーマシューティカルズ社（現在はセルジーン社の一部）によって開発された。 (ja) Romidepsyna, znana również pod nazwą handlową Istodax – lek przeciwnowotworowy stosowany w skórnym chłoniaku T-komórkowym (CTCL) i innych obwodowych chłoniakach T-komórkowych (PTCL). Romidepsyna jest związkiem chemicznym pochodzenia naturalnego uzyskanym z bakterii Chromobacterium violaceum, który działa poprzez blokowanie enzymów – deacetylaz histonowych, przez co indukuje apoptozę. Jest czasem określany jako depsipeptyd, ze względu na klasę cząsteczek, do których należy. Romidepsyna została wyprodukowana w laboratoriach Gloucester Pharmaceuticals, która stała się własnością firmy farmaceutycznej Celgene. (pl) Romidepsin, även marknadsfört som Istodax, är ett läkemedel mot cancer. Det kan framställas ur bakterien Chromobacterium violaceum. Läkemedlet ägs av Gloucester Pharmaceuticals, en del av Celgene. Det utvecklades efter att jordprover från Japan analyserats av Fujisawa Pharmaceutical Company (i dag Astellas Pharma) 1994. Det är ett godkänt receptbelagt läkemedel i USA sedan 2009. Man forskar kring läkemedlet, bland annat om HIV-behandling och hur det påverkar autism. (sv) |
| dbo:alternativeName | Istodax (en) |
| dbo:casNumber | 128517-07-7 |
| dbo:chEBI | 61080 |
| dbo:chEMBL | 1213490 |
| dbo:fdaUniiCode | CX3T89XQBK |
| dbo:medlinePlus | a610005 |
| dbo:pubchem | 5352062 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Romidepsin_structure.png?width=300 |
| dbo:wikiPageExternalLink | http://www.clinicaltrials.gov/ct2/results%3Fterm=romidepsin |
| dbo:wikiPageID | 24314125 (xsd:integer) |
| dbo:wikiPageLength | 15480 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1121457020 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Cancer dbc:Depsipeptides dbr:Electrocardiography dbr:Electrolyte dbr:FDA_Fast_Track_Development_Program dbr:Anorexia_(symptom) dbr:University_of_Tokyo dbr:Vorinostat dbr:Depsipeptide dbr:In_vitro dbr:In_vivo dbr:Intravenous_therapy dbr:Leukopenia dbc:Prodrugs dbr:Natural_product dbr:Nausea dbr:Orphan_drug dbr:Organic_redox_reaction dbr:Anemia dbr:Antineoplastic dbr:Apoptosis dbr:Liver dbr:ClinicalTrials.gov dbr:Clinical_trial dbr:Peripheral_T-cell_lymphoma dbr:Prodrug dbr:Total_synthesis dbr:Celgene dbr:Trichostatin_A dbr:Tsukuba,_Ibaraki dbr:Cytotoxic dbr:Fatigue_(medical) dbc:Histone_deacetylase_inhibitors dbc:Orphan_drugs dbr:Cutaneous_T-cell_lymphoma dbr:Dysgeusia dbr:European_Medicines_Agency dbr:Cell_culture dbr:Chromobacterium_violaceum dbr:Histone_deacetylase_inhibitor dbr:Vomiting dbc:Antineoplastic_drugs dbr:Harvard_University dbr:Histone_deacetylase dbr:Astellas_Pharma dbc:Bristol_Myers_Squibb dbr:Adverse_drug_reaction dbc:Astellas_Pharma dbr:Disulfide_bond dbr:CHOP_(chemotherapy) dbr:CYP3A4 dbr:HDAC_inhibitor dbr:Infection dbr:Yamagata_Prefecture dbr:Mechanism_of_action dbr:Ex_vivo dbr:PLOS_Pathogens dbr:Thiol dbr:Thrombocytopenia dbr:Peripheral_T_cell_lymphoma dbr:T-cell |
| dbp:alt | Skeletal formula of romidepsin (en) |
| dbp:atcPrefix | L01 (en) |
| dbp:atcSuffix | XH02 (en) |
| dbp:bioavailability | Not applicable (en) |
| dbp:c | 24 (xsd:integer) |
| dbp:casNumber | 128517 (xsd:integer) |
| dbp:chebi | 61080 (xsd:integer) |
| dbp:chembl | 1213490 (xsd:integer) |
| dbp:chemspiderid | 10122002 (xsd:integer) |
| dbp:colwidth | 30 (xsd:integer) |
| dbp:eliminationHalfLife | 10800.0 |
| dbp:h | 36 (xsd:integer) |
| dbp:image | Romidepsin ball and spoke.png (en) |
| dbp:iupacName | -7 (xsd:integer) |
| dbp:iupharLigand | 7006 (xsd:integer) |
| dbp:legalUs | Rx-only (en) |
| dbp:licenceUs | Romidepsin (en) |
| dbp:medlineplus | a610005 (en) |
| dbp:metabolism | Hepatic (en) |
| dbp:n | 4 (xsd:integer) |
| dbp:o | 6 (xsd:integer) |
| dbp:pregnancyUs | D (en) |
| dbp:proteinBound | 92 (xsd:integer) |
| dbp:pubchem | 5352062 (xsd:integer) |
| dbp:routesOfAdministration | dbr:Intravenous_therapy |
| dbp:s | 2 (xsd:integer) |
| dbp:smiles | C/C=C\1/CN[C@H]CC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | OHRURASPPZQGQM-GCCNXGTGSA-N (en) |
| dbp:synonyms | FK228; FR901228; Istodax (en) |
| dbp:tradename | Istodax (en) |
| dbp:unii | CX3T89XQBK (en) |
| dbp:verifiedfields | changed (en) |
| dbp:verifiedrevid | 387635110 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:width | 150 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Intracellular_chemotherapeutic_agents dbt:HDAC_inhibitors |
| dcterms:subject | dbc:Depsipeptides dbc:Prodrugs dbc:Histone_deacetylase_inhibitors dbc:Orphan_drugs dbc:Antineoplastic_drugs dbc:Bristol_Myers_Squibb dbc:Astellas_Pharma |
| gold:hypernym | dbr:Agent |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAntineoplasticDrugs yago:WikicatOrphanDrugs yago:Agent114778436 yago:Antineoplastic102722458 yago:CausalAgent100007347 yago:CytotoxicDrug103157987 yago:Drug103247620 yago:Inhibitor114724436 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:WikicatHistoneDeacetylaseInhibitors dbo:Drug yago:Substance100020090 |
| rdfs:comment | Romidepsin, also known as Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs). Romidepsin is a natural product obtained from the bacterium Chromobacterium violaceum, and works by blocking enzymes known as histone deacetylases, thus inducing apoptosis. It is sometimes referred to as depsipeptide, after the class of molecules to which it belongs. Romidepsin is branded and owned by Gloucester Pharmaceuticals, now a part of Celgene. (en) ロミデプシン（INN: romidepsin）とは、（CTCL）ならびにその他の（PTCLs）に使用される抗がん剤である。商品名はIstodax。ロミデプシンは細菌から得られる天然物であり、ヒストン脱アセチル化酵素の働きを妨げることによって、細胞にアポトーシスを誘導する。また、属する化合物群に因んで「デプシペプチド」と呼ばれることもある。ロミデプシンはグロスター・ファーマシューティカルズ社（現在はセルジーン社の一部）によって開発された。 (ja) Romidepsyna, znana również pod nazwą handlową Istodax – lek przeciwnowotworowy stosowany w skórnym chłoniaku T-komórkowym (CTCL) i innych obwodowych chłoniakach T-komórkowych (PTCL). Romidepsyna jest związkiem chemicznym pochodzenia naturalnego uzyskanym z bakterii Chromobacterium violaceum, który działa poprzez blokowanie enzymów – deacetylaz histonowych, przez co indukuje apoptozę. Jest czasem określany jako depsipeptyd, ze względu na klasę cząsteczek, do których należy. Romidepsyna została wyprodukowana w laboratoriach Gloucester Pharmaceuticals, która stała się własnością firmy farmaceutycznej Celgene. (pl) Romidepsin, även marknadsfört som Istodax, är ett läkemedel mot cancer. Det kan framställas ur bakterien Chromobacterium violaceum. Läkemedlet ägs av Gloucester Pharmaceuticals, en del av Celgene. Det utvecklades efter att jordprover från Japan analyserats av Fujisawa Pharmaceutical Company (i dag Astellas Pharma) 1994. Det är ett godkänt receptbelagt läkemedel i USA sedan 2009. Man forskar kring läkemedlet, bland annat om HIV-behandling och hur det påverkar autism. (sv) |
| rdfs:label | ロミデプシン (ja) Romidepsyna (pl) Romidepsin (en) Romidepsin (sv) |
| owl:sameAs | freebase:Romidepsin yago-res:Romidepsin wikidata:Romidepsin http://azb.dbpedia.org/resource/رومیدپسین dbpedia-cy:Romidepsin dbpedia-fa:Romidepsin dbpedia-hu:Romidepsin dbpedia-ja:Romidepsin dbpedia-pl:Romidepsin dbpedia-ro:Romidepsin dbpedia-sh:Romidepsin dbpedia-sr:Romidepsin dbpedia-sv:Romidepsin dbpedia-vi:Romidepsin https://global.dbpedia.org/id/4ue5S |
| prov:wasDerivedFrom | wikipedia-en:Romidepsin?oldid=1121457020&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Romidepsin_structure.png wiki-commons:Special:FilePath/Romidepsin_ball_and_spoke.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Romidepsin |
| is dbo:wikiPageRedirects of | dbr:Istodax dbr:ATC_code_L01XX39 dbr:ATCvet_code_QL01XX39 dbr:FK-228 dbr:FK228 dbr:FR901228 |
| is dbo:wikiPageWikiLink of | dbr:Epigenetic_priming dbr:Epigenetics_of_depression dbr:List_of_antineoplastic_agents dbr:List_of_chemotherapeutic_agents dbr:Depsipeptide dbr:Istodax dbr:Epigenetic_therapy dbr:Epigenetics_of_autism dbr:Epstein–Barr_virus–associated_lymphoproliferative_diseases dbr:Lung_cancer dbr:Mature_T-cell_lymphoma dbr:Cutaneous_T-cell_lymphoma dbr:Chromatin_remodeling dbr:Histone_deacetylase_inhibitor dbr:ATC_code_L01XX39 dbr:ATCvet_code_QL01XX39 dbr:Gregory_L._Verdine dbr:Histone_deacetylase dbr:ATC_code_L01 dbr:Sézary_disease dbr:FK-228 dbr:FK228 dbr:FR901228 dbr:Cancer_epigenetics dbr:List_of_drugs:_Rf–Rz |
| is foaf:primaryTopic of | wikipedia-en:Romidepsin |
