SDHB (original) (raw)
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene. The succinate dehydrogenase (also called SDH or Complex II) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. It is also connected to the SDHC/SDHD subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. The subunit is an iron-sulfur protein with three iron-sulfur clusters. It weighs 30 kDa.
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| dbo:abstract | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene. The succinate dehydrogenase (also called SDH or Complex II) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. It is also connected to the SDHC/SDHD subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. The subunit is an iron-sulfur protein with three iron-sulfur clusters. It weighs 30 kDa. (en) SDHB adalah berkas genetik pada lokasi 1p36.1-p35 dengan ekspresi genetik berupa protein sub-unit B dari suksinat dehidrogenase. Sub-unit B terdiri dari 3 kluster yang kaya akan sisteina. Mutasi pada gen akan menyebabkan dan , disfungsi mitokondria dan . (in) SDHB (англ. Succinate dehydrogenase complex iron sulfur subunit B) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 280 амінокислот, а молекулярна маса — 31 630. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до оксидоредуктаз. Задіяний у таких біологічних процесах як транспорт, цикл трикарбонових кислот, транспорт електронів. Білок має сайт для зв'язування з іонами металів, іоном заліза, групою 4fe-4s, залізо-сірчаною групою, групою 2fe-2s. Локалізований у мембрані, мітохондрії, внутрішній мембрані мітохондрії. (uk) |
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| dbo:wikiPageWikiLink | dbr:Nerve_growth_factor dbr:Neural_crest dbr:Hydrogen_bond dbr:Renal_cell_carcinoma dbr:Cytosol dbr:Ubiquinol dbr:Vitamin_C dbr:Carbonyl dbr:Deprotonation dbr:Penetrance dbr:Semiquinone dbc:EC_1.3.5 dbr:Nuclear_DNA dbr:Citric_Acid_Cycle dbr:Fumarate dbr:Gene dbr:Mitochondria dbr:Monocytes dbr:Apoptosis dbr:Embryo dbr:File:SDHBfunction.svg dbr:Tumor_suppressor_gene dbr:District_health_board dbr:Iron-sulfur_protein dbr:Locus_(genetics) dbr:Adenosine_triphosphate dbr:Flavin_adenine_dinucleotide dbr:Paraganglioma dbr:Germline dbr:Protein dbr:Hydroxylation dbr:Hypoxia_(medical) dbr:Atomic_mass_unit dbc:Tumor_suppressor_genes dbr:Superoxide dbr:Cofactor_(biochemistry) dbr:Mitochondrial_DNA dbr:Pheochromocytoma dbr:FADH2 dbr:Knudson_hypothesis dbr:Catalysis dbr:Chromosome_1_(human) dbr:Loss_of_heterozygosity dbr:SDHA dbr:SDHD dbr:Ubiquinone dbr:Exon dbr:Succinate_dehydrogenase_complex_subunit_C dbr:Iron-sulphur_cluster dbr:Succinate_dehydrogenase dbr:Transmembrane dbr:Hypoxia_inducible_factor dbr:SDHC_(gene) dbr:Cosubstrate dbr:Respiratory_chain dbr:Prolyl_hydroxylase dbr:Iron_sulfur_cluster dbr:Α-ketoglutarate dbr:Succinate dbr:File:SDHBpathways.svg |
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| dcterms:subject | dbc:EC_1.3.5 dbc:Tumor_suppressor_genes |
| gold:hypernym | dbr:Protein |
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| rdfs:comment | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene. The succinate dehydrogenase (also called SDH or Complex II) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. It is also connected to the SDHC/SDHD subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. The subunit is an iron-sulfur protein with three iron-sulfur clusters. It weighs 30 kDa. (en) SDHB adalah berkas genetik pada lokasi 1p36.1-p35 dengan ekspresi genetik berupa protein sub-unit B dari suksinat dehidrogenase. Sub-unit B terdiri dari 3 kluster yang kaya akan sisteina. Mutasi pada gen akan menyebabkan dan , disfungsi mitokondria dan . (in) SDHB (англ. Succinate dehydrogenase complex iron sulfur subunit B) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 280 амінокислот, а молекулярна маса — 31 630. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | SDHB (in) SDHB (en) SDHB (uk) |
| owl:sameAs | freebase:SDHB yago-res:SDHB wikidata:SDHB http://bs.dbpedia.org/resource/SDHB dbpedia-id:SDHB dbpedia-uk:SDHB https://global.dbpedia.org/id/VnZm |
| prov:wasDerivedFrom | wikipedia-en:SDHB?oldid=1116893842&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/SDHBfunction.svg wiki-commons:Special:FilePath/SDHBpathways.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:SDHB |
| is dbo:wikiPageDisambiguates of | dbr:SDH |
| is dbo:wikiPageRedirects of | dbr:SDHB_(gene) |
| is dbo:wikiPageWikiLink of | dbr:Housekeeping_gene dbr:Hypoxia-inducible_factor dbr:List_of_human_protein-coding_genes_3 dbr:Gastrointestinal_stromal_tumor dbr:Anthony_Gill_(professor) dbr:Ferredoxin dbr:Paraganglioma dbr:Chromosome_1 dbr:List_of_OMIM_disorder_codes dbr:Maryland_cultivation_of_strawberry dbr:Hereditary_diffuse_gastric_cancer dbr:ISCU dbr:Pheochromocytoma dbr:Cancer_syndrome dbr:Carney's_triad dbr:SDH dbr:SDHA dbr:SDHD dbr:Succinate_dehydrogenase_complex_subunit_C dbr:Succinate_dehydrogenase dbr:SDHB_(gene) dbr:SDHAF1 |
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