Stanol ester (original) (raw)
Stanol esters is a heterogeneous group of chemical compounds known to reduce the level of low-density lipoprotein (LDL) cholesterol in blood when ingested, though to a much lesser degree than prescription drugs such as statins. The starting material is phytosterols from plants. These are first hydrogenated to give a plant stanol which is then esterified with a mixture of fatty acids also derived from plants. Plant stanol esters are found naturally occurring in small quantities in fruits, vegetables, nuts, seeds, cereals, legumes, and vegetable oils.
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| dbo:abstract | Stanol esters is a heterogeneous group of chemical compounds known to reduce the level of low-density lipoprotein (LDL) cholesterol in blood when ingested, though to a much lesser degree than prescription drugs such as statins. The starting material is phytosterols from plants. These are first hydrogenated to give a plant stanol which is then esterified with a mixture of fatty acids also derived from plants. Plant stanol esters are found naturally occurring in small quantities in fruits, vegetables, nuts, seeds, cereals, legumes, and vegetable oils. Stanol ester is often added to rapeseed oil based margarine or other foods for its health benefits. Studies have indicated that consumption of about 2-3 grams per day provides a reduction in LDL cholesterol of about 10-15%. The compound itself passes through the gut, with very little entering the blood stream or lymph. Its presence in the gut, however, reduces both the amount of cholesterol the body absorbs from food and the reabsorption of the cholesterol component of bile. Despite a well documented cholesterol lowering effect, there are no data available indicating that functional foods supplemented with plant sterol esters reduce cardiovascular events. They are used in food products such as Benecol. Sterol esters can also be used for the same purpose. These compounds have the same effect to LDL, but they are partially absorbed by the body. The effects of higher serum plant sterol levels are so far not completely understood. (en) Stanolesters vormen een heterogene groep van chemisch samengestelde stoffen die bekendstaan om de verlagende invloed op (LDL)- cholesterol in het bloed na inname. Het basismateriaal van stanol bestaat uit plantaardige fytosterolen, die worden gehydrogeneerd waardoor de plantenstanol ontstaat. Vervolgens wordt deze stof veresterd met een mix van plantaardige vetzuren. Natuurlijke planten-stanolesters komen voor in fruit, groenten, noten, zaden, graan, peulvruchten en plantaardige oliën. Hoewel de werking gelijk is aan die van statines worden stanolesters als medicijn veel minder vaak voorgeschreven dan deze stoffen. Stanolesters worden vaak toegevoegd aan op koolzaadolie gebaseerde margarine of andere voedingsmiddelen in verband met gezondheidsvoordelen. Diverse studies wezen uit dat consumptie van circa 2 gram per dag een LDL-cholesterolverlaging van ongeveer 10% bewerkstelligt. De verbinding zelf gaat door het maag-darmkanaal zonder dat het de bloedstroom ooit bereikt (dit in tegenstelling tot statines). De aanwezigheid van stanolesters vermindert zowel de hoeveelheid cholesterol die het bloed opneemt uit het voedsel als de heropname van de cholesterolcomponent welke in gal zit. Het stanolester werd ontwikkeld door , een Finse chemicus. Het wordt op de markt gebracht door het Finse onder de handelsnaam ®. hebben een identieke werking als stanol, en worden vaker ingezet om cholesterol te verlagen. De sterolesters hebben eenzelfde effect op LDL, maar worden echter wél door het lichaam geabsorbeerd. De effecten van hoger gedoseerde plantensterolen-niveaus worden nog niet goed begrepen. (nl) |
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| dbo:wikiPageExternalLink | http://www.benecol.net/hcp.asp%3FviewID=2924 http://circ.ahajournals.org/cgi/content/full/103/8/1177 https://web.archive.org/web/20041217121515/http:/www.eatright.org/Public/NutritionInformation/92_9290.cfm https://web.archive.org/web/20080827192343/http:/www.benecol.net/ |
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| rdfs:comment | Stanol esters is a heterogeneous group of chemical compounds known to reduce the level of low-density lipoprotein (LDL) cholesterol in blood when ingested, though to a much lesser degree than prescription drugs such as statins. The starting material is phytosterols from plants. These are first hydrogenated to give a plant stanol which is then esterified with a mixture of fatty acids also derived from plants. Plant stanol esters are found naturally occurring in small quantities in fruits, vegetables, nuts, seeds, cereals, legumes, and vegetable oils. (en) Stanolesters vormen een heterogene groep van chemisch samengestelde stoffen die bekendstaan om de verlagende invloed op (LDL)- cholesterol in het bloed na inname. Het basismateriaal van stanol bestaat uit plantaardige fytosterolen, die worden gehydrogeneerd waardoor de plantenstanol ontstaat. Vervolgens wordt deze stof veresterd met een mix van plantaardige vetzuren. Natuurlijke planten-stanolesters komen voor in fruit, groenten, noten, zaden, graan, peulvruchten en plantaardige oliën. (nl) |
| rdfs:label | Stanolester (nl) Stanol ester (en) |
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