FBXW8 (original) (raw)

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Protein-coding gene in humans

FBXW8
Identifiers
Aliases	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8
External IDs	OMIM: 609073; MGI: 1923041; HomoloGene: 17731; GeneCards: FBXW8; OMA:FBXW8 - orthologs
Gene location (Human)Chr.Chromosome 12 (human)[1]Band12q24.22Start116,910,950 bp[1]End117,031,148 bp[1]
Gene location (Mouse)Chr.Chromosome 5 (mouse)[2]Band5|5 FStart118,203,030 bp[2]End118,293,529 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed instromal cell of endometriumgonadventricular zonebone marrow cellsislet of Langerhansganglionic eminenceepithelium of colontesticlepopliteal arterytibial arteriesTop expressed inotic vesicleotic placodesacculeinterventricular septuminternal carotid arteryexternal carotid arterysomitecalvariayolk saclumbar spinal ganglionMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding ubiquitin-protein transferase activity Cellular component perinuclear region of cytoplasm Golgi apparatus Cul7-RING ubiquitin ligase complex SCF ubiquitin ligase complex 3M complex cytoplasm cytosol Biological process cell population proliferation positive regulation of dendrite morphogenesis spongiotrophoblast layer development labyrinthine layer blood vessel development Golgi organization protein ubiquitination protein polyubiquitination post-translational protein modification positive regulation of transcription factor catabolic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez26259231672EnsemblENSG00000174989ENSMUSG00000032867UniProtQ8N3Y1Q8BIA4RefSeq (mRNA)NM_012174NM_153348NM_172721RefSeq (protein)NP_036306NP_699179NP_766309Location (UCSC)Chr 12: 116.91 – 117.03 MbChr 5: 118.2 – 118.29 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.[5][6][7]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174989 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032867 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
6. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
7. ^ a b "Entrez Gene: FBXW8 F-box and WD repeat domain containing 8".

• Tsutsumi T, Kuwabara H, Arai T, et al. (2008). "Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice". Mol. Cell. Biol. 28 (2): 743–51. doi:10.1128/MCB.01665-07. PMC 2223430. PMID 17998335.
• Koch HB, Zhang R, Verdoodt B, et al. (2007). "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach". Cell Cycle. 6 (2): 205–17. doi:10.4161/cc.6.2.3742. PMID 17314511.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Watanabe N, Arai H, Nishihara Y, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. Bibcode:2004PNAS..101.4419W. doi:10.1073/pnas.0307700101. PMC 384762. PMID 15070733.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dias DC, Dolios G, Wang R, Pan ZQ (2003). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.