ICK (gene) (original) (raw)

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Protein-coding gene in the species Homo sapiens

CILK1
Identifiers
Aliases	CILK1, ECO, LCK2, MRK, intestinal cell (MAK-like) kinase, intestinal cell kinase, EJM10, ICK, ciliogenesis associated kinase 1, hICK
External IDs	OMIM: 612325; MGI: 1934157; HomoloGene: 69218; GeneCards: CILK1; OMA:CILK1 - orthologs
Gene location (Human)Chr.Chromosome 6 (human)[1]Band6p12.1Start53,001,279 bp[1]End53,061,824 bp[1]
Gene location (Mouse)Chr.Chromosome 9 (mouse)[2]Band9|9 E1Start78,016,474 bp[2]End78,079,389 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inpalpebral conjunctivaleft adrenal glandleft adrenal cortexright adrenal cortexganglionic eminenceolfactory zone of nasal mucosarectumplacentaAchilles tendonC1 segmentTop expressed intrigeminal ganglionRostral migratory streamepithelium of stomachPaneth cellgastrulaexternal carotid arterygenital tubercleciliary bodysubstantia nigrazygoteMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function transferase activity nucleotide binding protein kinase activity metal ion binding kinase activity protein serine/threonine kinase activity protein binding ATP binding magnesium ion binding Cellular component ciliary basal body cytosol cell projection ciliary tip cytoskeleton cilium ciliary base nucleus cytoplasm fibrillar center Biological process intracellular signal transduction phosphorylation multicellular organism development protein phosphorylation cell projection organization signal transduction intraciliary anterograde transport intraciliary retrograde transport cilium assembly regulation of gene expression intraciliary transport Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez2285856542EnsemblENSG00000112144ENSMUSG00000009828UniProtQ9UPZ9Q9JKV2RefSeq (mRNA)NM_014920NM_016513NM_001375397NM_001375398NM_001375399NM_001375400NM_001375401NM_001375402NM_173041NM_001163780NM_019987RefSeq (protein)NP_055735NP_057597NP_001362326NP_001362327NP_001362328NP_001362329NP_001362330NP_001362331NP_001157252NP_064371Location (UCSC)Chr 6: 53 – 53.06 MbChr 9: 78.02 – 78.08 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase, Intestinal cell kinase or ICK[5] is an enzyme that in humans is encoded by the ICK gene.[6][7]

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112144 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009828 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "ICK intestinal cell kinase [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-01-26.
6. ^ Yang T, Jiang Y, Chen J (Jul 2002). "The identification and subcellular localization of human MRK". Biomol Eng. 19 (1): 1–4. doi:10.1016/S1389-0344(02)00002-3. PMID 12103360.
7. ^ a b "Entrez Gene: ICK intestinal cell (MAK-like) kinase".

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Togawa K, Yan YX, Inomoto T, et al. (2000). "Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases". J. Cell. Physiol. 183 (1): 129–39. doi:10.1002/(SICI)1097-4652(200004)183:1<129::AID-JCP15>3.0.CO;2-S. PMID 10699974. S2CID 41279862.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
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• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fu Z, Schroeder MJ, Shabanowitz J, et al. (2005). "Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase". Mol. Cell. Biol. 25 (14): 6047–64. doi:10.1128/MCB.25.14.6047-6064.2005. PMC 1168834. PMID 15988018.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.