Protein wntless homolog (original) (raw)

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Protein-coding gene in the species Homo sapiens

WLS
Identifiers
Aliases	WLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator, Wnt ligand secretion mediator, ZKS
External IDs	OMIM: 611514; MGI: 1915401; HomoloGene: 11779; GeneCards: WLS; OMA:WLS - orthologs
Gene location (Human)Chr.Chromosome 1 (human)[1]Band1p31.3Start68,098,473 bp[1]End68,233,120 bp[1]
Gene location (Mouse)Chr.Chromosome 3 (mouse)[2]Band3|3 H4Start159,545,309 bp[2]End159,644,300 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed instromal cell of endometriumEpithelium of choroid plexusretinal pigment epitheliumcorpus epididymisgastric mucosaislet of Langerhansgallbladderoptic nerveendothelial cellbronchial epithelial cellTop expressed incalvariamolarleft lung lobeolfactory epitheliumpineal glandchoroid plexus of fourth ventriclemaxillary prominenceright kidneycorneal stromaseminal vesiculaMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding Wnt-protein binding mu-type opioid receptor binding Cellular component integral component of membrane endocytic vesicle membrane endosome Golgi apparatus early endosome membrane membrane plasma membrane dendrite membrane trans-Golgi network early endosome dendrite cytoplasm extracellular exosome cytoplasmic vesicle membrane endoplasmic reticulum membrane cytoplasmic vesicle Golgi membrane endoplasmic reticulum Biological process exocrine pancreas development positive regulation of canonical Wnt signaling pathway positive regulation of Wnt protein secretion mesoderm formation hindbrain development multicellular organism development positive regulation of Wnt signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling intracellular protein transport anterior/posterior axis specification midbrain development Wnt signaling pathway Wnt protein secretion Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez7997168151EnsemblENSG00000116729ENSMUSG00000028173UniProtQ5T9L3Q6DID7RefSeq (mRNA)NM_001002292NM_001193334NM_024911NM_026582NM_001356349NM_001356350RefSeq (protein)NP_001002292NP_001180263NP_079187NP_080858NP_001343278NP_001343279Location (UCSC)Chr 1: 68.1 – 68.23 MbChr 3: 159.55 – 159.64 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLS gene .[5] Wntless is a receptor for Wnt proteins in Wnt-secreting cells.[6]

Wntless was shown to be a cargo for the retromer complex.[6] It has been found essential for hair follicle induction.[7]

A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.[8]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116729 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028173 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "WLS - Protein wntless homolog - Homo sapiens (Human) - WLS gene & protein". www.uniprot.org. Retrieved 30 May 2022.
6. ^ a b Eaton S (January 2008). "Retromer retrieves wntless". Developmental Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
7. ^ Fu J, Hsu W (April 2013). "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology. 133 (4): 890–898. doi:10.1038/jid.2012.407. PMC 3594635. PMID 23190887.
8. ^ Chai G, Szenker-Ravi E, Chung C, Li Z, Wang L, Khatoo M, et al. (September 2021). "A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion". The New England Journal of Medicine. 385 (14): 1292–1301. doi:10.1056/NEJMoa2033911. PMC 9017221. PMID 34587386.

• Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K (May 2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells". Cell. 125 (3): 509–522. doi:10.1016/j.cell.2006.02.049. PMID 16678095. S2CID 7841408.

• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.

• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, et al. (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.

• GPR177+receptor,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.