REL (original) (raw)

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Protein-coding gene in the species Homo sapiens

REL
Identifiers
Aliases REL, C-Rel, REL proto-oncogene, NF-kB subunit, HIVEN86A, IMD92
External IDs OMIM: 164910; MGI: 97897; HomoloGene: 2182; GeneCards: REL; OMA:REL - orthologs
Gene location (Human)Chromosome 2 (human)Chr.Chromosome 2 (human)[1]Chromosome 2 (human)Genomic location for RELGenomic location for RELBand2p16.1Start60,881,521 bp[1]End60,931,612 bp[1]
Gene location (Mouse)Chromosome 11 (mouse)Chr.Chromosome 11 (mouse)[2]Chromosome 11 (mouse)Genomic location for RELGenomic location for RELBand11 A3.2|11 14.36 cMStart23,686,847 bp[2]End23,720,970 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inbuccal mucosa cellbone marrowsecondary oocytebone marrow cellsmonocyteepithelium of colonmucosa of urinary bladderhuman peniscartilage tissuesuperficial temporal arteryTop expressed inmesenteric lymph nodesbloodspleengranulocyteconjunctival fornixskin of external earbone marrowsecondary oocytecumulus cellstroma of bone marrowMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding chromatin binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component cytoplasm cytosol I-kappaB/NF-kappaB complex transcription regulator complex nucleoplasm nucleus Biological process response to cytokine regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II negative regulation of interferon-beta production negative regulation of gene expression transcription, DNA-templated positive regulation of transcription, DNA-templated NIK/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response inflammatory response positive regulation of transcription by RNA polymerase II negative regulation of neuron death I-kappaB kinase/NF-kappaB signaling transcription by RNA polymerase II Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez596619696EnsemblENSG00000162924ENSMUSG00000020275UniProtQ04864P15307RefSeq (mRNA)NM_001291746NM_002908NM_009044RefSeq (protein)NP_001278675NP_002899NP_033070Location (UCSC)Chr 2: 60.88 – 60.93 MbChr 11: 23.69 – 23.72 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.[5] The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer.[6] c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162924 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020275 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.
  6. ^ Li T, Li X, Chen YH (May 2020). "c-Rel is a myeloid checkpoint for cancer immunotherapy". Nature Cancer. 1 (5): 507–517. doi:10.1038/s43018-020-0061-3. PMC 7808269. PMID 33458695.
  7. ^ Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (March 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene. 23 (13): 2275–86. doi:10.1038/sj.onc.1207410. PMID 14755244.