SSR4 (original) (raw)

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Protein-coding gene in the species Homo sapiens

SSR4
Identifiers
Aliases	SSR4, TRAPD, CDG1Y, signal sequence receptor subunit 4
External IDs	OMIM: 300090; MGI: 1099464; HomoloGene: 4573; GeneCards: SSR4; OMA:SSR4 - orthologs
Gene location (Human)Chr.X chromosome (human)[1]BandXq28Start153,793,516 bp[1]End153,798,499 bp[1]
Gene location (Mouse)Chr.X chromosome (mouse)[2]BandX A7.3|X 37.41 cMStart72,830,634 bp[2]End72,834,436 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inpituitary glandanterior pituitarybody of pancreasseminal vesiculatracheapylorusminor salivary glandscorpus epididymisstromal cell of endometriumbody of stomachTop expressed inseminal vesiculaparotid glandislet of Langerhanssubmandibular glandmolargastrulalacrimal glandcervixcalvariadeciduaMore reference expression dataBioGPSMore reference expression data
OrthologsSpeciesHuman MouseEntrez674820832EnsemblENSG00000180879ENSMUSG00000002014UniProtP51571Q62186RefSeq (mRNA)NM_001204526NM_001204527NM_006280NM_001166480NM_009279NM_001358212NM_001358213RefSeq (protein)NP_001191455NP_001191456NP_006271NP_001159952NP_033305NP_001345141NP_001345142Location (UCSC)Chr X: 153.79 – 153.8 MbChr X: 72.83 – 72.83 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Translocon-associated protein subunit delta is a protein that in humans is encoded by the SSR4 gene.[5][6]

SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric length from the ALD gene. Although alternative splicing of exon 5 has not been detected in the human SSR4 gene, transcript variants missing the region homologous to the human exon 5 have been detected in both Xenopus laevis and Mus musculus.[6]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180879 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002014 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
6. ^ a b "Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)". Archived from the original on 2021-04-18. Retrieved 2017-09-11.

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