TRA2A (original) (raw)

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Protein-coding gene in the species Homo sapiens

TRA2A
Identifiers
Aliases	TRA2A, AWMS1, HSU53209, transformer 2 alpha homolog
External IDs	OMIM: 602718; MGI: 1933972; HomoloGene: 40866; GeneCards: TRA2A; OMA:TRA2A - orthologs
Gene location (Human)Chr.Chromosome 7 (human)[1]Band7p15.3Start23,504,780 bp[1]End23,532,041 bp[1]
Gene location (Mouse)Chr.Chromosome 6 (mouse)[2]Band6|6 B2.3Start49,220,858 bp[2]End49,240,967 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inright uterine tubebuccal mucosa cellright ovaryganglionic eminenceleft ovaryventricular zonecanal of the cervixsural nervebody of uterusright lobe of thyroid glandTop expressed inpineal glandGonadal ridgeabdominal wallmaxillary prominencemandibular prominencetail of embryodermissuperior cervical ganglionepiblastventricular zoneMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function nucleic acid binding RNA binding Cellular component nucleolus intracellular membrane-bounded organelle nucleus ribonucleoprotein complex Biological process mRNA splicing, via spliceosome mRNA processing RNA splicing positive regulation of mRNA splicing, via spliceosome Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez29896101214EnsemblENSG00000164548ENSMUSG00000029817UniProtQ13595Q6PFR5RefSeq (mRNA)NM_001282757NM_001282758NM_001282759NM_013293NM_001362759NM_001362760NM_001362761NM_198102NM_001347209NM_001362188RefSeq (protein)NP_001269686NP_001269687NP_001269688NP_037425NP_001349688NP_001349689NP_001349690n/aLocation (UCSC)Chr 7: 23.5 – 23.53 MbChr 6: 49.22 – 49.24 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.[5][6][7]

This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164548 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029817 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Dauwalder B, Amaya-Manzanares F, Mattox W (Oct 1996). "A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions". Proc Natl Acad Sci U S A. 93 (17): 9004–9. Bibcode:1996PNAS...93.9004D. doi:10.1073/pnas.93.17.9004. PMC 38585. PMID 8799144.
6. ^ Tacke R, Tohyama M, Ogawa S, Manley JL (May 1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.
7. ^ a b "Entrez Gene: TRA2A transformer-2 alpha".

• Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Shin C, Feng Y, Manley JL (2004). "Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock". Nature. 427 (6974): 553–8. Bibcode:2004Natur.427..553S. doi:10.1038/nature02288. PMID 14765198. S2CID 4423246.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034. S2CID 895879.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.