Prafull Singh | Amity University (original) (raw)

Papers by Prafull Singh

Geospatial techniques have become one of the leading tools in the field of natural sciences for a... more Geospatial techniques have become one of the leading tools in the field of natural sciences for assessment, monitoring and management of natural resources, particularly in groundwater research. The paper discusses the demarcation and assessment of groundwater potential zones using geospatial techniques in the Deccan Volcanic Province of Maharashtra, India, using multi-criteria analyses. The study incorporates integration of thematic information (geomorphology, lithology, drainage density, slope and lineaments) in a GIS environment in order to identify groundwater potential zones. The methodology adopted can be used as a rapid assessment tool in groundwater exploration and is helpful in predictive groundwater resource management. Multi-criteria evaluation techniques were used to integrate all the thematic layers. Individual themes and their corresponding categories were assigned a knowledge base ranking from 1 to 5, depending on their importance for groundwater potential. Using the Raster calculator tool in Arc GIS software, all thematic maps were integrated to produce a composite groundwater potential map of the study area. The identified groundwater potential zones were classified into four classes, from excellent to poor. The generated groundwater potential zones were validated with field checks and borewell/dugwell yield data, and showed consistency with the observations.

Applied Biochemistry and Biotechnology, 2015

Many viral proteins are responsible for causing induction of apoptosis in the target cells. Hemag... more Many viral proteins are responsible for causing induction of apoptosis in the target cells. Hemagglutinin neuraminidase (HN), a multifunctional protein of Newcastle disease virus (NDV), is one of such proteins. The present study was undertaken to determine the apoptotic potential of the HN gene in cultured human cervical cancer cell line (HeLa cell) and to elucidate the molecular mechanisms involved. The results of the study indicate that HN protein causes apoptosis in HeLa cells, as observed by the translocation of Phosphatidylserine, activation of caspases, cleavage of poly (ADP-ribose) polymerase (PARP), and DNA fragmentation. Further, we report that expression of HN protein upregulates the SAPK/JNK pathway leading to transactivation of c-Jun which in turn activates apoptosis signaling. The results of our study provide an insight into the mechanism through which HN induces apoptosis.

Land use mapping is fundamental for assessment, managing and protection of natural resources of a... more Land use mapping is fundamental for assessment, managing and protection of natural resources of a region and the information on the existing land use is one of the prime pre-requisites for suggesting better use of terrain. Advances in satellite sensor and their analysis techniques are making remote sensing systems realistic and attractive for use in research and management of natural resources. Land use maps are valuable tools for agricultural and natural resources studies. Due to strength of natural resources, updating these maps is essential. Employing traditional methods through aerial photos interpretation to produce such maps are costly and time consuming. With the growth of population and socio-economic activities, natural land cover is being modified for various development purposes. This has increased the rate of changes on land-use pattern over time and thus, affecting the overall ecosystem health. Land use mapping is an important tool for land management and monitoring. Th...

Short term monitoring on land use / land cover change is an important input for natural resource ... more Short term monitoring on land use / land cover change is an important input for natural resource and environmental management for fast growing cities. Satellite based change detection & Monitoring are very scientific data base for decision makers and urban planners. By keeping these points in the objective, the present work has been carried out for in and around Dibrugarh area using remote sensing and GIS techniques for land use change analysis from 2008 to 2011.The results observed from the classification of satellite images of the area are associated with different type of land use pattern such settlement, vegetations, fallow land, river, riverbed and barren /waste lands. Major Changes are observed in fallow land which was 13 % in 2008 and increase 28 % in 2011. Settlement increase by 8 %, vegetation by 3 % and minor changes over other land use categories were observed. The growth of cities and lands conversion into urban areas, results in significant impacts on ecosystems. Monito...

Systematic assessment of availability of groundwater resources are the main options for the susta... more Systematic assessment of availability of groundwater resources are the main options for the sustainable exploration and management of water resources particularly hard rock and semi-arid regions. In the present paper an attempts made to assess the regional groundwater status of the Gwalior area which is facing acute water crisis for drinking as well for Irrigation purpose. The present paper discusses the utility of remote sensing and GIS techniques for regional level groundwater prospect of the area by analyzing the hydro-geomorphic and lithological diversity. For the evaluation of hydrogeomorphic and lithological units an integrated GIS based modeling approach has been used for the assessment of groundwater prospect of the area. The results obtained by this work can be the primary level survey for water resource evaluation and management for proper planning and management of groundwater resources in different hydrogeological environment.

The world is facing severe problem -energy crisis, environmental problem, this makes peoples to f... more The world is facing severe problem -energy crisis, environmental problem, this makes peoples to focus their courtesy on sustainable energy resources for their survival. Biomass technology is a right option in this regards because of its renewable, abundant, environment friendly nature. Gasification systems require high temperatures and an oxygenstarved environment to convert biomass which is usually wet organic domestic waste, organic industrial wastes, manure, sludge etc., into a gas (a mixture of hydrogen, carbon monoxide, and methane). This gas fuels a gas turbine, which runs an electric generator. Changes in wood moisture are well tolerated by the process. During the testing program, as feedstock moisture levels were changed from level to another, the Gasifier and combustor reactors responded within minutes to the changes. When large changes in moisture content were made rapidly (20 to 30% by volume), Gasifier and combustor temperatures change more significantly so that a final steady state temperature, at each condition, were slightly delayed (about 1 to 2 hours depending on the magnitude of the moisture change) due to response of the system refractory. Even though the final steady state condition required some time to be reached, the gas production rate adjusted within minutes to within +/ 5% of the final equilibrium value.

Assessment of groundwater prospects has been carried out for the Morar river basin in Gwalior dis... more Assessment of groundwater prospects has been carried out for the Morar river basin in Gwalior district, Madhya Pradesh. Groundwater prospect of the basin has been delineated from the satellite data by the integration of geology, geomorphology, lineament and slope and classified as Excellent to poor groundwater potential zones using GIS. The results obtained from remotely sensed data cross checked with the bore well yield data and found in good agreement. This depicts the positive prospective zones in the study area for exploration of groundwater in future. Water level fluctuation map prepared from the pre-and post-monsoon water level data do not show any significant change except at some locations in alluvial area Net groundwater availability also calculated is about 63.634 MCM. The calculated annual draft of Groundwater from dug wells and tube wells for all users is 70.051 MCM revealing a deficit in groundwater storage in the Basin.

Land use and land cover changes due to fast growing cities over short time are very major environ... more Land use and land cover changes due to fast growing cities over short time are very major environmental issues for developing countries. The change analysis of various land use pattern within the city are very important factor for proper management so decision makers and planners to take an effective measures. Satellite based earth observation and monitoring is very scientific and effective tool to detect and monitor land use changes. In the present work an attempt has been made to analyze the temporal land use pattern changes for major land use classes of Noida, which is one the fast growing city of North Central Region (NCR) by using multi temporal satellite data of Landsat. Spatio-temporal assessment of land use pattern for the year 2010 and 2013 were analyzed using ARC GIS and ENVI software's. The results show the rates of changes are high in terms of conversion of open land into built-up land and increase of built-up area within four years. It is also observed that the surf...

In the present study the issue of temporal changes of surface water use pattern has been evaluat... more In the present study the issue of temporal changes of surface water use pattern has been evaluated by identifying
hydrological features and water use of a very important watershed of Gwalior and adjoining areas of Madhya Pradesh using multi-spectral satellite and latest GIS technologies.

Cell biology international, Jan 4, 2015

Nuclear factor kappa-B (NF-κB), a key anti-apoptotic factor, plays a critical role in tumor cell ... more Nuclear factor kappa-B (NF-κB), a key anti-apoptotic factor, plays a critical role in tumor cell growth, metastasis and angiogenesis. The transcriptional activity of NF-κB is normally suppressed in the cytoplasm due to its association with a natural inhibitor molecule IκB. Phosphorylation of the IκB at Ser 32 and Ser 36 by the IκB kinase complex (IKK) marks the degradation of the molecule by the 26S proteasome. As NF-κB is constitutively activated in the most of the tumor cells, inhibition of the activities of IKK may significantly sensitize the tumor cells to apoptosis. In the present study, we investigated the effect of IκB kinase specific blocker PS1145 on DMBA induced skin tumor of male Wistar rats. We examined the apoptotic effect of PS1145 on DMBA induced tumor by various histopathological and molecular techniques. Our results demonstrated the significant expression of major pro-apoptotic genes like caspase 2, 3, 8, 9 and p53 in PS1145 treated tumor bearing group at mRNA level...

Applied Biochemistry and Biotechnology, 2015

The use of viruses for treatment of cancer overcomes the bottlenecks of chemotherapy and radiothe... more The use of viruses for treatment of cancer overcomes the bottlenecks of chemotherapy and radiotherapy. Several viruses and their proteins have been evaluated for oncolytic effect. The VP3 protein (apoptin) of chicken anemia virus is one such protein with an inherent ability to lyse cancer and transformed cells while leaving normal cells unharmed. In the present study, the apoptosis inducing potential of VP3 protein of CAV was evaluated in human cervical cancer cell line (HeLa). It was found that in VP3-induced apoptosis, caspase-dependent intrinsic pathway plays an important role with the cleavage of poly (ADP-ribose) polymerase (PARP) and there was no evidence of involvement of death receptor-mediated extrinsic pathway. The results of this study provide intuitive information and strengthen the candidacy of apoptin as a viral oncotherapeutic agent.

The Indian journal of medical research, 2012

Cancer is one of the major causes of death worldwide. In spite of achieving significant successes... more Cancer is one of the major causes of death worldwide. In spite of achieving significant successes in medical sciences in the past few decades, the number of deaths due to cancer remains unchecked. The conventional chemotherapy and radiotherapy have limited therapeutic index and a plethora of treatment related side effects. This situation has provided an impetus for search of novel therapeutic strategies that can selectively destroy the tumour cells, leaving the normal cells unharmed. Viral oncotherapy is such a promising treatment modality that offers unique opportunity for tumour targeting. Numerous viruses with inherent anti-cancer activity have been identified and are in different phases of clinical trials. In the era of modern biotechnology and with better understanding of cancer biology and virology, it has become feasible to engineer the oncolytic viruses (OVs) to increase their tumour selectivity and enhance their oncolytic activity. In this review, the mechanisms by which on...

Bhopal, the capital city of Madhya Pradesh having highest population density and situated over Ma... more Bhopal, the capital city of Madhya Pradesh having highest population density and situated over Malwa plateau. The area in and around Bhopal city faces acute water scarcity and chronically drought prone region. The present study was under taken to evaluate various hydrogeomorphological units of the area through the use of high resolution satellite data and field survey. The evaluated hydrogeomorphological units along with geological setup and topographic condition are integrated in GIS environment on the basis of contribution of particular factor in groundwater occurrence and movement. Digital image processing techniques were also applied for better understanding of the features which are helpful for identification of boundaries of various landforms and geology. The deeply and moderately weathered pediplains with shallow alluvial plains are the most potential zones for groundwater exploration and site for water management plan.

The world is facing severe problem energy crisis, environmental problem, this makes peoples to ... more The world is facing severe problem energy crisis, environmental problem, this makes peoples to focus their courtesy on sustainable energy resources for their survival. Biomass technology is a right option in this regards because of its renewable, abundant, environment friendly ...

The quantitative analysis of the watershedis vital to understand the hydrological setup of any te... more The quantitative analysis of the watershedis
vital to understand the hydrological setup of any terrain.
The present study deals with quantitative evaluation of
Swarnrekha Watershed, Madhya Pradesh, India based on
IRS satellite data and SRTM DEM. Morphometric
parameters of the watershed were evaluated by computations
of linear and areal aspect using standard methodology
in GIS environment. ARC GIS software was utilized for
morphometric component analysis and delineation of the
watershed using SRTM digital elevation model (DEM).
The watershed is drained by a fifth-order river and shown a
dendritic drainage pattern, which is a sign of the homogeneity
in texture and lack of structural control. The drainage
density in the area has been found to be low which
indicates that the area possesses highly permeable soils and
low relief. The bifurcation ratio varies from 3.00 to 5.60
and elongation ratio is 0.518 which reveals that the basin
belongs to the elongated shape basin and has the potential
for water management. The main objective of the paper is
to extract the morphometric parameters of the watershed
and their relevance in water resource evaluation management.
The results observed from this work would be useful
in categorization of watershed for future water management
and selection recharge structure in the area.

Assessment of landslide is an important aspect for evaluation, zoning and risk management .Numero... more Assessment of landslide is an important aspect for evaluation, zoning and risk management .Numerous methods and techniques were discussed by the researchers for landslide hazard zonation mapping of different landslide sensitive zones of the world for decision making. The Present research work is an integrated approach of geospatial technology for landslide susceptibility mapping for part of North Sikkim Himalaya using spatial Analyst tool of ARC GIS software.
The important factors which are necessary landslide susceptibility mapping in hard rock terrain particularly for Himalayan region such as geology/structure, drainage density, Land use /land cover and slope were discussed and evaluated by using satellite images , field based data and published maps. All the extracted thematic maps were reclassified on the basis of their importance and characteristics for landslide susceptibility mapping of the area under GIS environment by applying weighted Overlay method in ARC GIS. Finally integrated landslide susceptibility map of the area generated and classified under four major categories from low to very high landslide susceptibility zones.

Keywords: Landslide Susceptibility Mapping, Remote Sensing, ARC GIS, North Sikkim Himalaya.

Applied Biochemistry and Biotechnology, 2015

Cell biology international, Jan 4, 2015

Applied Biochemistry and Biotechnology, 2015

The Indian journal of medical research, 2012

Keywords: Landslide Susceptibility Mapping, Remote Sensing, ARC GIS, North Sikkim Himalaya.