Structural basis for the subunit assembly of the anaphase-promoting complex (original) (raw)

• Peters, J. M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nature Rev. Mol. Cell Biol. 7, 644–656 (2006)
  Article CAS Google Scholar
• Thornton, B. R. & Toczyski, D. P. Precise destruction: an emerging picture of the APC. Genes Dev. 20, 3069–3078 (2006)
  Article CAS PubMed Google Scholar
• Sullivan, M. & Morgan, D. O. Finishing mitosis, one step at a time. Nature Rev. Mol. Cell Biol. 8, 894–903 (2007)
  Article ADS CAS Google Scholar
• Glotzer, M., Murray, A. W. & Kirschner, M. W. Cyclin is degraded by the ubiquitin pathway. Nature 349, 132–138 (1991)
  Article ADS CAS PubMed Google Scholar
• Pfleger, C. M. & Kirschner, M. W. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14, 655–665 (2000)
  CAS PubMed PubMed Central Google Scholar
• Kimata, Y., Baxter, J. E., Fry, A. M. & Yamano, H. A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment. Mol. Cell 32, 576–583 (2008)
  Article CAS PubMed Google Scholar
• Eytan, E., Moshe, Y., Braunstein, I. & Hershko, A. Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding. Proc. Natl Acad. Sci. USA 103, 2081–2086 (2006)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Passmore, L. A. & Barford, D. Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. EMBO Rep. 6, 873–878 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Sikorski, R. S., Boguski, M. S., Goebl, M. & Hieter, P. A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis. Cell 60, 307–317 (1990)
  Article CAS PubMed Google Scholar
• Hirano, T., Kinoshita, N., Morikawa, K. & Yanagida, M. Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+ . Cell 60, 319–328 (1990)
  Article CAS PubMed Google Scholar
• Lupas, A., Baumeister, W. & Hofmann, K. A repetitive sequence in subunits of the 26S proteasome and 20S cyclosome (anaphase-promoting complex). Trends Biochem. Sci. 22, 195–196 (1997)
  Article CAS PubMed Google Scholar
• Thornton, B. R. et al. An architectural map of the anaphase-promoting complex. Genes Dev. 20, 449–460 (2006)
  Article CAS PubMed PubMed Central Google Scholar
• Wendt, K. S. et al. Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. Nature Struct. Biol. 8, 784–788 (2001)
  Article CAS PubMed Google Scholar
• Matyskiela, M. E. & Morgan, D. O. Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol. Cell 34, 68–80 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Vodermaier, H. C., Gieffers, C., Maurer-Stroh, S., Eisenhaber, F. & Peters, J. M. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. Curr. Biol. 13, 1459–1468 (2003)
  Article CAS PubMed Google Scholar
• Schwickart, M. et al. Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27. Mol. Cell. Biol. 24, 3562–3576 (2004)
  Article CAS PubMed PubMed Central Google Scholar
• Oelschlaegel, T. et al. The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1. Cell 120, 773–788 (2005)
  Article CAS PubMed Google Scholar
• Au, S. W., Leng, X., Harper, J. W. & Barford, D. Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. J. Mol. Biol. 316, 955–968 (2002)
  Article CAS PubMed Google Scholar
• Zhang, Z. et al. Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture. J. Mol. Biol. 397, 1316–1328 (2010)
  Article CAS PubMed Google Scholar
• Wang, J., Dye, B. T., Rajashankar, K. R., Kurinov, I. & Schulman, B. A. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structure. Nature Struct. Mol. Biol. 16, 987–989 (2009)
  Article CAS Google Scholar
• Zhang, Z., Kulkarni, K., Hanrahan, S. J., Thompson, A. J. & Barford, D. The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27. EMBO J. 29, 3733–3744 (2010)
  Article CAS PubMed PubMed Central Google Scholar
• Han, D. et al. Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7. J. Biol. Chem. 284, 15137–15146 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Dube, P. et al. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Mol. Cell 20, 867–879 (2005)
  Article CAS PubMed Google Scholar
• Herzog, F. et al. Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science 323, 1477–1481 (2009)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Ohi, M. D. et al. Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol. Cell 28, 871–885 (2007)
  Article CAS PubMed PubMed Central Google Scholar
• Passmore, L. A. et al. Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Mol. Cell 20, 855–866 (2005)
  Article CAS PubMed Google Scholar
• da Fonseca, P. C. et al. Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature advance online publication. 10.1038/nature09625 (24 November 2010)
• Berger, I., Fitzgerald, D. J. & Richmond, T. J. Baculovirus expression system for heterologous multiprotein complexes. Nature Biotechnol. 22, 1583–1587 (2004)
  Article CAS Google Scholar
• Fitzgerald, D. J. et al. Multiprotein expression strategy for structural biology of eukaryotic complexes. Structure 15, 275–279 (2007)
  Article CAS PubMed Google Scholar
• Passmore, L. A. et al. Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J. 22, 786–796 (2003)
  Article CAS PubMed PubMed Central Google Scholar
• Passmore, L. A., Barford, D. & Harper, J. W. Purification and assay of the budding yeast anaphase-promoting complex. Methods Enzymol. 398, 195–219 (2005)
  Article CAS PubMed Google Scholar
• Hall, M. C., Torres, M. P., Schroeder, G. K. & Borchers, C. H. Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. J. Biol. Chem. 278, 16698–16705 (2003)
  Article CAS PubMed Google Scholar
• Kraft, C. et al. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J. 22, 6598–6609 (2003)
  Article CAS PubMed PubMed Central Google Scholar
• Steen, J. A. et al. Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proc. Natl Acad. Sci. USA 105, 6069–6074 (2008)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Sikorski, R. S., Michaud, W. A. & Hieter, P. p62 cdc23 of Saccharomyces cerevisiae: a nuclear tetratricopeptide repeat protein with two mutable domains. Mol. Cell. Biol. 13, 1212–1221 (1993)
  Article CAS PubMed PubMed Central Google Scholar
• Schwab, M., Neutzner, M., Mocker, D. & Seufert, W. Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC. EMBO J. 20, 5165–5175 (2001)
  Article CAS PubMed PubMed Central Google Scholar
• Izawa, D. & Pines, J. Evidence for how APC-C-Cdc20 changes its substrate specificity in mitosis. Nature Cell Biol. doi:10.1038/ncb2165. (in the press)
  Article CAS PubMed PubMed Central Google Scholar
• Hayes, M. J. et al. Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C. Nature Cell Biol. 8, 607–614 (2006)
  Article CAS PubMed Google Scholar
• Wolthuis, R. et al. Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol. Cell 30, 290–302 (2008)
  Article CAS PubMed Google Scholar
• Duda, D. M. et al. Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell 134, 995–1006 (2008)
  Article CAS PubMed PubMed Central Google Scholar
• Sobott, F., Hernandez, H., McCammon, M. G., Tito, M. A. & Robinson, C. V. A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies. Anal. Chem. 74, 1402–1407 (2002)
  Article CAS PubMed Google Scholar
• van Heel, M. et al. Single-particle electron cryo-microscopy: towards atomic resolution. Q. Rev. Biophys. 33, 307–369 (2000)
  Article CAS PubMed Google Scholar
• Frank, J. et al. SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J. Struct. Biol. 116, 190–199 (1996)
  Article CAS PubMed Google Scholar
• Ludtke, S. J., Baldwin, P. R. & Chiu, W. EMAN: semiautomated software for high-resolution single-particle reconstructions. J. Struct. Biol. 128, 82–97 (1999)
  Article CAS PubMed Google Scholar
• Gloeckner, C. J., Boldt, K., Schumacher, A., Roepman, R. & Ueffing, M. A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics 7, 4228–4234 (2007)
  Article CAS PubMed Google Scholar
• Warrens, A. N., Jones, M. D. & Lechler, R. I. Splicing by overlap extension by PCR using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest. Gene 186, 29–35 (1997)
  Article CAS PubMed Google Scholar
• Heckman, K. L. & Pease, L. R. Gene splicing and mutagenesis by PCR-driven overlap extension. Nature Protocols 2, 924–932 (2007)
  Article CAS PubMed Google Scholar
• Fitzgerald, D. J. et al. Protein complex expression by using multigene baculoviral vectors. Nature Methods 3, 1021–1032 (2006)
  Article CAS PubMed Google Scholar
• Hernández, H. & Robinson, C. V. Determining the stoichiometry and interactions of macromolecular assemblies from mass spectrometry. Nature Protocols 2, 715–726 (2007)
  Article PubMed Google Scholar
• McKay, A. R., Ruotolo, B. T., Ilag, L. L. & Robinson, C. V. Mass measurements of increased accuracy resolve heterogeneous populations of intact ribosomes. J. Am. Chem. Soc. 128, 11433–11442 (2006)
  Article CAS PubMed Google Scholar
• Taverner, T. et al. Subunit architecture of intact protein complexes from mass spectrometry and homology modeling. Acc. Chem. Res. 41, 617–627 (2008)
  Article CAS PubMed Google Scholar
• Pettersen, E. F. et al. UCSF Chimera—a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605–1612 (2004)
  Article CAS PubMed Google Scholar
• Navaza, J., Lepault, J., Rey, F. A., Alvarez-Rua, C. & Borge, J. On the fitting of model electron densities into EM reconstructions: a reciprocal-space formulation. Acta Crystallogr. D 58, 1820–1825 (2002)
  Article CAS PubMed Google Scholar
• Penczek, P. A., Yang, C., Frank, J. & Spahn, C. M. Estimation of variance in single-particle reconstruction using the bootstrap technique. J. Struct. Biol. 154, 168–183 (2006)
  Article CAS PubMed Google Scholar
• Ashkenazy, H., Erez, E., Martz, E., Pupko, T. & Ben-Tal, N. ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res. 38 (Suppl. 2). W529–W533 (2010)
  Article CAS PubMed PubMed Central Google Scholar
• Landau, M. et al. ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res. 33 (Suppl. 2). W299–W302 (2005)
  Article ADS CAS PubMed PubMed Central Google Scholar