Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region (original) (raw)
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Acknowledgements
We thank T. Kanabayashi for the preparation of immunohistochemical staining; N. Aoki for assistance with bone sections; N. Suzuki for technical assistance; N. Kinukawa for assistance with statistical analysis; and F. Ishidate (Carl Zeiss) for assistance with microscopy. This work was supported by the Japan Ministry of Education, Culture, Sports, Science and Technology grant to F.I. and by the US National Institutes of Health grant to L.D.S.
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Authors and Affiliations
- Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama, 230-0045, Japan
Fumihiko Ishikawa, Shuro Yoshida & Yoriko Saito - Laboratory for Immunogenomics, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama, 230-0045, Japan
Atsushi Hijikata, Hiroshi Kitamura & Osamu Ohara - Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan
Fumihiko Ishikawa, Shuro Yoshida, Noriyuki Saito, Mitsuhiro Fukata & Mine Harada - Center for Cellular and Molecular Medicine, Kyushu University Hospital, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan
Toshihiro Miyamoto & Koichi Akashi - Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, 02114, Massachusetts, USA
Yoriko Saito - Nippon Becton Dickinson Company, 4-15-1 Akasaka Minato-ku, Tokyo, 107-0052, Japan
Satoshi Tanaka & Hiroko Tomiyama - Carl Zeiss, 22 Honshio-cho, Shinjuku-ku, Tokyo, 160-0003, Japan
Ryu Nakamura & Toru Tanaka - The Jackson Laboratory, 600 Main Street, Bar Harbor, 04609, Maine, USA
Bonnie Lyons & Leonard D Shultz - First Department of Pathology, Kurume University School of Medicine, 67 Asahi-cho, Kurume, 830-0011, Japan
Koichi Ohshima - Department of Hematology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo, 105-8470, Japan
Naoyuki Uchida & Shuichi Taniguchi - Department of Human Genome Technology, Kazusa DNA Research Institute, 2-6-7 Kazusa Kamatari, Kisarazu, 290-0818, Japan
Osamu Ohara - Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, 02115, Massachusetts, USA
Koichi Akashi
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- Fumihiko Ishikawa
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Contributions
F.I., overall experimental design, transplantation, data analysis, manuscript preparation and discussion; S.Y. transplantation and data analysis; Y.S. overall experimental design, data analysis, statistical analysis, manuscript preparation and discussion; A.H., microarray analysis; H.K., microarray analysis; S.T., flow cytometry; R.N., confocal imaging; T.T., confocal imaging; H.T., flow cytometry; N.S., data analysis; M.F., data analysis; T.M., discussion; B.L., data analysis; K.O., histological analysis; N.U., discussion; S.T., discussion; O.O., microarray analysis and discussion; K.A., discussion; M.H., discussion; L.D.S., discussion.
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Correspondence toFumihiko Ishikawa.
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Ishikawa, F., Yoshida, S., Saito, Y. et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.Nat Biotechnol 25, 1315–1321 (2007). https://doi.org/10.1038/nbt1350
- Received: 28 December 2006
- Accepted: 24 September 2007
- Published: 21 October 2007
- Issue Date: November 2007
- DOI: https://doi.org/10.1038/nbt1350