Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region (original) (raw)

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Acknowledgements

We thank T. Kanabayashi for the preparation of immunohistochemical staining; N. Aoki for assistance with bone sections; N. Suzuki for technical assistance; N. Kinukawa for assistance with statistical analysis; and F. Ishidate (Carl Zeiss) for assistance with microscopy. This work was supported by the Japan Ministry of Education, Culture, Sports, Science and Technology grant to F.I. and by the US National Institutes of Health grant to L.D.S.

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Authors and Affiliations

  1. Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama, 230-0045, Japan
    Fumihiko Ishikawa, Shuro Yoshida & Yoriko Saito
  2. Laboratory for Immunogenomics, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho Tsurumi-ku, Yokohama, 230-0045, Japan
    Atsushi Hijikata, Hiroshi Kitamura & Osamu Ohara
  3. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan
    Fumihiko Ishikawa, Shuro Yoshida, Noriyuki Saito, Mitsuhiro Fukata & Mine Harada
  4. Center for Cellular and Molecular Medicine, Kyushu University Hospital, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan
    Toshihiro Miyamoto & Koichi Akashi
  5. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, 02114, Massachusetts, USA
    Yoriko Saito
  6. Nippon Becton Dickinson Company, 4-15-1 Akasaka Minato-ku, Tokyo, 107-0052, Japan
    Satoshi Tanaka & Hiroko Tomiyama
  7. Carl Zeiss, 22 Honshio-cho, Shinjuku-ku, Tokyo, 160-0003, Japan
    Ryu Nakamura & Toru Tanaka
  8. The Jackson Laboratory, 600 Main Street, Bar Harbor, 04609, Maine, USA
    Bonnie Lyons & Leonard D Shultz
  9. First Department of Pathology, Kurume University School of Medicine, 67 Asahi-cho, Kurume, 830-0011, Japan
    Koichi Ohshima
  10. Department of Hematology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo, 105-8470, Japan
    Naoyuki Uchida & Shuichi Taniguchi
  11. Department of Human Genome Technology, Kazusa DNA Research Institute, 2-6-7 Kazusa Kamatari, Kisarazu, 290-0818, Japan
    Osamu Ohara
  12. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, 02115, Massachusetts, USA
    Koichi Akashi

Authors

  1. Fumihiko Ishikawa
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  2. Shuro Yoshida
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  3. Yoriko Saito
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  4. Atsushi Hijikata
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  5. Hiroshi Kitamura
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  6. Satoshi Tanaka
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  7. Ryu Nakamura
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  8. Toru Tanaka
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  9. Hiroko Tomiyama
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  10. Noriyuki Saito
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  11. Mitsuhiro Fukata
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  12. Toshihiro Miyamoto
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  13. Bonnie Lyons
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  14. Koichi Ohshima
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  15. Naoyuki Uchida
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  16. Shuichi Taniguchi
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  17. Osamu Ohara
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  18. Koichi Akashi
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  19. Mine Harada
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  20. Leonard D Shultz
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Contributions

F.I., overall experimental design, transplantation, data analysis, manuscript preparation and discussion; S.Y. transplantation and data analysis; Y.S. overall experimental design, data analysis, statistical analysis, manuscript preparation and discussion; A.H., microarray analysis; H.K., microarray analysis; S.T., flow cytometry; R.N., confocal imaging; T.T., confocal imaging; H.T., flow cytometry; N.S., data analysis; M.F., data analysis; T.M., discussion; B.L., data analysis; K.O., histological analysis; N.U., discussion; S.T., discussion; O.O., microarray analysis and discussion; K.A., discussion; M.H., discussion; L.D.S., discussion.

Corresponding author

Correspondence toFumihiko Ishikawa.

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Ishikawa, F., Yoshida, S., Saito, Y. et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.Nat Biotechnol 25, 1315–1321 (2007). https://doi.org/10.1038/nbt1350

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