Targeting of CD44 eradicates human acute myeloid leukemic stem cells (original) (raw)

• Wang, J.C. & Dick, J.E. Cancer stem cells: lessons from leukemia. Trends Cell Biol. 15, 494–501 (2005).
  Article CAS PubMed Google Scholar
• Hope, K., Jin, L. & Dick, J.E. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat. Immunol. 5, 738–743 (2004).
  Article CAS PubMed Google Scholar
• Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645–648 (1994).
  Article CAS PubMed Google Scholar
• Bonnet, D. & Dick, J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730–737 (1997).
  Article CAS PubMed Google Scholar
• Guan, Y. & Hogge, D.E. Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML). Leukemia 14, 2135–2141 (2000).
  Article CAS PubMed Google Scholar
• Guzman, M.L. et al. Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 98, 2301–2307 (2001).
  Article CAS PubMed Google Scholar
• Tallman, M.S. New strategies for the treatment of acute myeloid leukemia including antibodies and other novel agents. Hematology Am. Soc. Hematol. Educ. Program 2005, 143–150 (2005).
  Article Google Scholar
• Wilson, A. & Trumpp, A. Bone-marrow haematopoietic-stem-cell niches. Nat. Rev. Immunol. 6, 93–106 (2006).
  Article CAS PubMed Google Scholar
• Nilsson, S.K. et al. Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro. Blood 101, 856–862 (2003).
  Article CAS PubMed Google Scholar
• Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836–841 (2003).
  Article CAS PubMed Google Scholar
• Calvi, L.M. et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841–846 (2003).
  Article CAS PubMed Google Scholar
• Cancelas, J.A. & Williams, D.A. Stem cell mobilization by β2-agonists. Nat. Med. 12, 278–279 (2006).
  Article CAS PubMed Google Scholar
• Lapidot, T., Dar, A. & Kollet, O. How do stem cells find their way home? Blood 106, 1901–1910 (2005).
  Article CAS PubMed Google Scholar
• Kortlepel, K., Bendall, L.J. & Gottlieb, D.J. Human acute myeloid leukaemia cells express adhesion proteins and bind to bone marrow fibroblast monolayers and extracellular matrix proteins. Leukemia 7, 1174–1179 (1993).
  CAS PubMed Google Scholar
• Reuss-Borst, M.A., Buhring, H.J., Klein, G. & Muller, C.A. Adhesion molecules on CD34+ hematopoietic cells in normal human bone marrow and leukemia. Ann. Hematol. 65, 169–174 (1992).
  Article CAS PubMed Google Scholar
• Liesveld, J.L. et al. Adhesive interactions of normal and leukemic human CD34+ myeloid progenitors: role of marrow stromal, fibroblast, and cytomatrix components. Exp. Hematol. 19, 63–70 (1991).
  CAS PubMed Google Scholar
• Tavor, S. et al. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res. 64, 2817–2824 (2004).
  Article CAS PubMed Google Scholar
• Till, J.E. & McCulloch, E.A. Hemopoietic stem cell differentiation. Biochim. Biophys. Acta 605, 431–459 (1980).
  CAS PubMed Google Scholar
• Ponta, H., Sherman, L. & Herrlich, P.A. CD44: from adhesion molecules to signalling regulators. Nat. Rev. Mol. Cell Biol. 4, 33–45 (2003).
  Article CAS PubMed Google Scholar
• Bendall, L.J., Bradstock, K.F. & Gottlieb, D.J. Expression of CD44 variant exons in acute myeloid leukemia is more common and more complex than that observed in normal blood, bone marrow or CD34+ cells. Leukemia 14, 1239–1246 (2000).
  Article CAS PubMed Google Scholar
• Legras, S. et al. A strong expression of CD44-6v correlates with shorter survival of patients with acute myeloid leukemia. Blood 91, 3401–3413 (1998).
  CAS PubMed Google Scholar
• Avigdor, A. et al. CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 103, 2981–2989 (2004).
  Article CAS PubMed Google Scholar
• Turley, E.A., Noble, P.W. & Bourguignon, L.Y. Signaling properties of hyaluronan receptors. J. Biol. Chem. 277, 4589–4592 (2002).
  Article CAS PubMed Google Scholar
• Charrad, R.S. et al. Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia. Nat. Med. 5, 669–676 (1999).
  Article CAS PubMed Google Scholar
• Charrad, R.S. et al. Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines. Blood 99, 290–299 (2002).
  Article CAS PubMed Google Scholar
• Gadhoum, Z. et al. CD44: a new means to inhibit acute myeloid leukemia cell proliferation via P27Kip1. Blood 103, 1059–1068 (2004).
  Article CAS PubMed Google Scholar
• Mohle, R. et al. The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell–derived factor-1. Blood 91, 4523–4530 (1998).
  CAS PubMed Google Scholar
• Mazurier, F., Doedens, M., Gan, O.I. & Dick, J.E. Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat. Med. 9, 959–963 (2003).
  Article CAS PubMed Google Scholar
• Mazurier, F., Gan, O., McKenzie, J., Doedens, M. & Dick, J. Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment. Blood 103, 545–552 (2004).
  Article CAS PubMed Google Scholar
• Madlambayan, G.J. et al. Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. Exp. Hematol. 33, 1229–1239 (2005).
  Article CAS PubMed Google Scholar
• Peled, A. et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283, 845–848 (1999).
  Article CAS PubMed Google Scholar
• Kim, C.F. et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121, 823–835 (2005).
  Article CAS PubMed Google Scholar
• Singh, S. et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 63, 5281–5288 (2003).
  Google Scholar
• Al-Hajj, M., Wicha, M., Morrison, S.J. & Clarke, M.F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA 100, 3983–3988 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Liotta, L.A. & Kohn, E.C. The microenvironment of the tumour-host interface. Nature 411, 375–379 (2001).
  Article CAS PubMed Google Scholar
• Woerner, S.M. et al. Expression of CD44 splice variants in normal, dysplastic, and neoplastic cervical epithelium. Clin. Cancer Res. 1, 1125–1132 (1995).
  CAS PubMed Google Scholar
• Jo, D.Y., Rafii, S., Hamada, T. & Moore, M.A. Chemotaxis of primitive hematopoietic cells in response to stromal cell–derived factor-1. J. Clin. Invest. 105, 101–111 (2000).
  Article CAS PubMed PubMed Central Google Scholar