MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation (original) (raw)
Kyriakis, J.M. in Protein Kinase Functions (ed. Woodgett, J.R.) 40–156 (Oxford University Press, Oxford, 2000). Google Scholar
Wojnowski, L. et al. Endothelial apoptosis in Braf-deficient mice. Nature Genet.16, 293–297 (1997). ArticleCAS Google Scholar
Wojnowski, L. et al. Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis. Mech. Dev.91, 97–104 (2000). ArticleCAS Google Scholar
Gallo, K.A. & Johnson, G.L. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nature Rev. Mol. Cell. Biol.3, 663–672 (2002). ArticleCAS Google Scholar
Sathyanarayana, P. et al. Activation of the Drosophila MLK by ceramide reveals TNF-α and ceramide as agonists of mammalian MLK3. Mol. Cell10, 1527–1533 (2002). ArticleCAS Google Scholar
Shen, Y.H. et al. Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors. J. Biol. Chem.278, 26715–26721 (2003). ArticleCAS Google Scholar
Zhang, B.-H. & Guan, K.-L. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J.19, 5429–5439 (2000). ArticleCAS Google Scholar
Chong, H., Lee, J. & Guan, K.-L. Positive and negative regulation of Raf kinase activity and function by phosphorylation. EMBO J.20, 3716–3727 (2001). ArticleCAS Google Scholar
Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature417, 949–954 (2002). ArticleCAS Google Scholar
Malumbres, M. & Barbacid, M. RAS oncogenes: the first 30 years. Nature Rev. Cancer3, 459–465 (2003). ArticleCAS Google Scholar
McCormick, F. Activators and effectors of ras p21 proteins. Curr. Opin. Genet. Dev.4, 71–76 (1994). ArticleCAS Google Scholar
Elbashir, S.M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature411, 494–498 (2001). ArticleCAS Google Scholar
Chi, J.T. et al. Genomewide view of gene silencing by small interfering RNAs. Proc. Natl Acad. Sci. USA.100, 6343–6346 (2003). ArticleCAS Google Scholar
Semizarov, D. et al. Specificity of short interfering RNA determined through gene expression signatures. Proc. Natl Acad. Sci. USA.100, 6347–6352 (2003). ArticleCAS Google Scholar
Kyriakis, J.M. et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature369, 156–160 (1994). ArticleCAS Google Scholar
Dumitru, C.D. et al. TNF-α induction by LPS is regulated posttranscriptionally via a Tpl-2/ERK-dependent pathway. Cell103, 1071–1083 (2000). ArticleCAS Google Scholar
Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H. & Williams, B.R.G. Activation of the interferon system by short-interfering RNAs. Nature Cell Biol.5, 834–839 (2003). ArticleCAS Google Scholar
Wan, P.T.C. et al. Mechanism of activation of the Raf-ERK signaling pathway by oncogenic mutations of B-RAF. Cell116, 855–867 (2004). ArticleCAS Google Scholar
Mercer, K.E. & Pritchard, C.A. Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim. Biophys. Acta1653, 25–40 (2003). CASPubMed Google Scholar
Mansour, S.J. et al. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science265, 966–970 (1994). ArticleCAS Google Scholar
Lavoie, J.N., L'Allemain, G., Brunet, A., Müller, R. & Pouysségur, J. Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by the p38/HOG MAPK pathway. J. Biol. Chem.271, 20608–20616 (1996). ArticleCAS Google Scholar
Brunet, A. et al. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J.18, 664–674 (1999). ArticleCAS Google Scholar
Balmanno, K. & Cook, S.J. Sustained MAP kinase activation is required for the expression of cyclin D1, p21 Cip1 and a subset of AP-1 proteins in CCL39 cells. Oncogene18, 3085–3097 (1999). ArticleCAS Google Scholar
Swenson, K.I., Winkler, K.E. & Means, A.R. A new identity for MLK3 as a NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. Mol. Biol. Cell14, 156–172 (2003). ArticleCAS Google Scholar
Sherr, C.J. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res.60, 3689–3695 (2000). CAS Google Scholar
McClatchey, A.I. Merlin and ERM proteins: unappreciated roles in cancer development? Nature Rev. Cancer3, 877–883 (2003). Article Google Scholar